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Topoxin
Beacon Pharmaceuticals PLC
Generic: Etoposide
Safety Advices
বাংলা
English
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Topoxin. Please consult your doctor.
CONSULT YOUR DOCTOR
Topoxin is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
UNSAFE
Topoxin is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
SAFE
Topoxin does not usually affect your ability to drive.
CAUTION
Topoxin should be used with caution in patients with kidney disease. Dose adjustment of Topoxin may be needed. Please consult your doctor.
Use of Topoxin is not recommended in patients with end-stage kidney disease.
CAUTION
Topoxin should be used with caution in patients with liver disease. Dose adjustment of Topoxin may be needed. Please consult your doctor.
Use of Topoxin is not recommended in patients with severe liver disease.
Medicine Overview of Topoxin 100mg/5ml Injection
Introduction
Topoxin is used to treat different cancers of lung, and testicles. It is also sometimes used to treat some other kinds of cancer in both men and women. It can be used on its own, or sometimes given together with certain other medicines as part of combination chemotherapy. Topoxin is given as slow injection into veins under the supervision of a healthcare professional and should not be self-administered. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to...
... Show moreUses of Topoxin
- Small cell lung cancer
- Testicular cancer
Side effects of Topoxin
Common
- Anemia (low number of red blood cells)
- Decreased blood cells (red cells, white cells, and platelets)
- Decreased white blood cell count
- Diarrhea
- Hair loss
- Liver damage
- Low blood platelets
- Nausea
- Rash
- Stomatitis (Inflammation of the mouth)
- Vomiting
How to use Topoxin
Your doctor or nurse will give you this medicine. Kindly do not self administer.
How Topoxin works
Topoxin is an anti-cancer medication. It works by suppressing the activity of an enzyme (topoisomerase II) involved in DNA multiplication of the cancer cells. This slows the growth of cancer cells and eventually kills them.
Brief Description
Indication
Lung cancer, Testicular cancer
Adult Dose
Intravenous
Testicular Cancer
50-100 mg/m²/day IV on days 1-5, OR
100 mg/m²/day IV on days 1, 3, 5
Repeat q3-4week
Small-Cell Lung Cancer
35 mg/m²/day IV for 4 days, OR
50 mg/m²/day IV for 5 days; repeat q3-4week
Oral
Small cell lung cancer
Adult: Twice the IV dose, rounded to the nearest 50 mg.
Renal Dose
Renal Impairment
CrCl >50 mL/min: Dose adjustment not necessary
CrCl 15-50 mL/min: 75% of regular dose
CrCl < 15 mL/min: Not studied; consider further dose reductions
Contraindication
Hypersensitivity, pregnancy, lactation.
Mode of Action
Etoposide is a derivative of podophyllotoxin that inhibits DNA synthesis resulting in the arrest of the cell cycle. At low doses, it inhibits cells from entering cell cycle and at high doses, cells entering mitosis are lysed.
Precaution
Skin reactions may occur with accidental exposure; renal or hepatic disease. Periodic CBCs should be done before, during and after therapy. Increased risk of etoposide-toxicity in patients with low serum albumin. Acrylic material has been shown to crack and leak when used with undiluted etoposide inj.
Lactation: not known if excreted in breast milk, discontinue drug or do not nurse
Side Effect
>10%
Leukopenia (60-91%),Nausea and Vomiting (30-40%),Thrombocytopenia (28-41%),Alopecia (20-90%),Anorexia (13%),Diarrhea (13%),Leukopenia (60-91%),Anemia (≤33%)
1-10%
Pancytopenia (7%),Stomatitis (6%),Hepatic toxicity (3%),Type 1 hypersensitivity (2%),Orthostatic hypotension (1-2%),Peripheral neuropathy (1-2%)
Frequency Not Defined
Malaise,Shivering,Asthenia,Fever,Mucous membrane inflammation,Hyperuricemia,Local soft tissue toxicity has been reported following extravasation; see section on IV information for extravasation management
Potentially Fatal: Severe myelosuppression, characterised by leucopaenia and thrombocytopaenia. Cardiotoxicity. Anaphylaxis.
Pregnancy Category Note
Pregnancy: Based on animal data and its mechanism of action, etoposide can cause fetal harm when administered to a pregnant woman; etoposide, the active moiety of etoposide phosphate is teratogenic in mice and rats advise pregnant women of potential hazard to a fetus; advise women of childbearing potential to avoid becoming pregnant Advise females of reproductive potential to use effective contraception during treatment and for 6 months after final dose In females of reproductive potential, may cause infertility and result in amenorrhea; premature menopause can occur; recovery of menses and ovulation is related to age at treatment Lactation: There is...
... Show moreInteraction
Synergism with other cytotoxic drugs. Caution when admin with drugs that inhibit phosphatase activity. Cyclosporin A may reduce the clearance of etoposide.
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