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Trin
Globe Pharmaceuticals Ltd.
Generic: Cetirizine Dihydrochloride
Safety Advices
বাংলা
English
UNSAFE
Trin may cause excessive drowsiness with alcohol.
SAFE IF PRESCRIBED
Trin is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
SAFE IF PRESCRIBED
Trin is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
Larger doses or prolonged use of Trin may cause sleepiness and other effects in the baby
SAFE
Trin does not usually affect your ability to drive.
CAUTION
Trin should be used with caution in patients with kidney disease. Dose adjustment of Trin may be needed. Please consult your doctor.
Not recommended in patients with severe kidney disease. May cause excessive sleepiness in patients with end stage kidney disease.
SAFE IF PRESCRIBED
Trin is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Trin may not be needed in these patients. Please consult your doctor.
Medicine Overview of Trin 5mg/5ml Syrup
Introduction
Trin belongs to a group of medicines called antihistamines. It is used to treat various allergic conditions such as hay fever, conjunctivitis and some skin reactions, and reactions to bites and stings. It relieves watery eyes, runny nose, sneezing, and itching. Trin can be taken with or without food. The dose required for you may vary depending on what you are taking it for. This medicine is usually taken in the evening but follow the advice of your doctor on how to take it. You may need this medicine only on days you have symptoms, but if you are taking...
... Show moreUses of Trin
- Allergic conditions
Side effects of Trin
Common
- Sleepiness
How to use Trin
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Trin may be taken with or without food, but it is better to take it at a fixed time.
How Trin works
Trin is an antihistaminic medication. It treats allergy symptoms such as itching, swelling, and rashes by blocking the effects of a chemical messenger (histamine) in the body.
Quick Tips
- Your doctor has prescribed Trin to help relieve allergy symptoms such as itching, swelling, and rashes.
- It's much less likely to make you feel sleepy than other similar medications.
- It is okay to take Trin with most other medications as it has few drug interactions.
- Use caution while driving or doing anything that requires concentration as Trin can cause dizziness and sleepiness.
- Do not drink alcohol while taking Trin as it may cause increased sleepiness.
- Stop taking Trin at least three days before taking an allergy test as it can affect the test results.
Brief Description
Indication
Allergic rhinitis, Hay fever, Allergies, Urticaria
Administration
May be taken with or without food.
Adult Dose
Oral
Allergic conditions
Adult: 10 mg once daily or 5 mg bid.
Elderly: Initially, 5 mg once daily.
Hepatic impairment: Initially, 5 mg once daily.
Syrup:
Adults: 2 teaspoon once daily or 1 teaspoon twice daily.
Child Dose
Oral
Allergic conditions
Child: 6-23 mth 2.5 mg once daily increased to max of 2.5 mg bid in childn >12 mth; 2-5 yr 5 mg once daily or in 2 divided doses; >6 yr 10 mg once daily or in 2 divided doses.
Syrup:
Children over 6 years: 2 teaspoon once daily or 1 teaspoon twice daily.
Children 2-6 years: 1 teaspoonful once daily or 1/2 teaspoon twice daily.
<2 years: Safety and efficacy not established
Renal Dose
Renal impairment
GFR >50 mL/min: Dose adjustment not necessary
GFR ? 50 mL/min: 5 mg PO qDay
Peritoneal dialysis: 5 mg PO qDay
Intermittent hemodialysis: 5 mg PO qDay; may also administer 3 times weekly
Contraindication
Hypersensitivity; lactation.
Mode of Action
Cetirizine is a potent and highly selective antagonist of the peripheral histamine H1-receptor on effector cells in the GI tract, blood vessels and resp tract.
Precaution
Hepatic or renal impairment; elderly; tasks requiring mental alertness eg, driving or operating heavy machinery; pregnancy.
Lactation: Excreted in breast milk; use not recommended
Side Effect
>10%
Somnolence (2-14%),Headache (11-14%)
1-10%
Fatigue (5.9%),Dry mouth (5%),Dizziness (2%),Diarrhea (2-3%),Malaise (4%),Bronchospasm (2-3%),Vomiting (2-3%),Epistaxis (2-4%)
<1%
Stomach pain,Drowsiness,Angioedema,Fussiness,Hallucinations,Hypotension,Tremor,Tongue discoloration
Pregnancy Category Note
Pregnancy
There are no adequate and well-controlled studies in pregnant women
Lactation
Cetirizine has been reported to be present in human breast milk
In mice and beagle dogs, studies indicated that cetirizine was excreted in milk
When a drug is present in animal milk, it is likely it will be present in human milk
Interaction
Additive CNS depression when administered concomitantly w/ other CNS depressants (e.g. sedatives, tranquilisers).
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