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Avotil
Rephco Pharmaceuticals Ltd.
Generic: Prochlorperazine Maleate
Safety Advices
বাংলা
English
UNSAFE
It is unsafe to consume alcohol with Avotil.
CONSULT YOUR DOCTOR
Information regarding the use of Avotil during pregnancy is not available. Please consult your doctor.
CONSULT YOUR DOCTOR
Avotil is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Occasional short-term use of Avotil for the treatment of nausea and vomiting poses little risk to the breastfed infant.
UNSAFE
Avotil may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
CAUTION
Avotil should be used with caution in patients with kidney disease. Dose adjustment of Avotil may be needed. Please consult your doctor.
CAUTION
Avotil should be used with caution in patients with liver disease. Dose adjustment of Avotil may be needed. Please consult your doctor.
Medicine Overview of Avotil 5mg Tablet
Introduction
Avotil is used to treat nausea, vomiting and dizziness due to ear diseases (Meniere’s syndrome). This medicine is also used in mental illnesses such as schizophrenia, mania and short term anxiety. Avotil is taken after meals in a dose and duration as advised by the doctor. The dose you are given will depend on your condition and how you respond to the medicine. You should take this medicine until your doctor tells you to stop. Let your doctor know about all other medications you are taking as some may affect, or be affected by this medicine. The most common side...
... Show moreUses of Avotil
- Nausea
- Vomiting
- Vertigo
- Meniere's disease
- Schizophrenia
Side effects of Avotil
Common
- Drowsiness
- Orthostatic hypotension (sudden lowering of blood pressure on standing)
How to use Avotil
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Avotil is to be taken with food.
How Avotil works
Avotil is a dopamine antagonist. It works by blocking the dopamine receptors in the region of brain that controls nausea and vomiting.
Quick Tips
- Avotil is used for the prevention and treatment of nausea and vomiting.
- It may also be used to treat dizziness associated with problems of the inner ear such as Meniere’s Syndrome.
- It may cause sleepiness. Don't drive or do anything requiring concentration until you know how it affects you.
- To lower the chance of feeling dizzy or passing out, rise slowly if you have been sitting or lying down.
- Avoid consuming alcohol when taking the Avotil as it may cause excessive drowsiness.
- It makes you more likely to get heatstroke. Avoid heavy exercising and drink plenty of fluids.
- It can cause your skin to be more sensitive to sunlight. Avoid exposure to direct sunlight while having this medicine.
Brief Description
Indication
Vertigo, Psychoses, Nausea and vomiting, Severe anxiety disorders
Administration
May be taken with or without food.
Adult Dose
Oral Prophylaxis of nausea and vomitting Adult: As maleate : 5-10 mg bid/tid. Nausea and vomiting Adult: As maleate : 20 mg, further doses are given if needed. Recommended buccal dose: As maleate: 3-6 mg bid. Psychoses Adult: As maleate : 12.5 mg bid for 7 days, adjusted gradually to 75-100 mg daily according to response. Usual maintenance dose: 25-50 mg daily. Adjunct in severe anxiety disorders Adult: As maleate: 5-10 mg, up to 3-4 times daily. Vertigo Adult: As maleate : 15-30 mg daily, given in divided doses. May reduce gradually to 5-10 mg daily. Recommended buccal dose: 3-6...
... Show moreChild Dose
Oral
Psychoses
Child: 1-5 yr: 1.25-2.5 mg;
5-12 yr: 2.5-5 mg.
May be given up to tid, if necessary.
Contraindication
CNS depression, comatose patients. Bone marrow depression, phaechromocytoma, prolactin-dependent tumours, hypersensitivity. Childn <2 yr. Pregnancy and lactation.
Mode of Action
Prochlorperazine blocks both postsynaptic dopamine receptors as well as the medullary chemo receptor trigger zone. It depresses hypothalamic and hypophyseal hormone release and posssesses alpha-adrenergic and anticholinergic inhibitory activity.
Precaution
Extrapyramidal syndrome, hypotension, epilepsy, impaired hepatic, renal, CV, cerebrovascular or respiratory function, glaucoma. May impair ability to drive or perform tasks requiring mental alertness or physical coordination. Parenteral use in children is not recommended. History of jaundice, parkinsonism, diabetes mellitus, hypothyroidism, myasthenia gravis, paralytic ileus, prostatic hyperplasia or urinary retention. Regular eye examinations are recommended in patients on long-term treatment.
Lactation: Phenothiazines may be excreted in breast milk; do not nurse
Side Effect
<1%
Insomnia,Restlessness,Dizziness,Anxiety,Euphoria,Agitation,Depression,Weakness,Headache,Cerebral edema,Poikilothermia,Tachycardia,ECG changes,Anorexia,Dyspepsia,Constipation,Diarrhea,Ileus,Blood dyscrasia,Galactorrhea,Gynecomastia,Ejaculatory disorder,Lens opacities (with prolonged use),Photosensitivity,Pruritus
Frequency Not Defined
Akathisia,Sedation,Anticholinergic effects,Weight gain,Oligomenorrhea or amenorrhea,Erectile dysfunction,Extrapyramidal symptoms (muscle stiffness, dystonia, parkinsonism, tardive dyskinesia),Neuroleptic malignant syndrome (infrequent but serious),Seizure,Decreased gag reflex,Confusion,Hypotension,Hypertension,Leukopenia,Agranulocytosis,Cholestatic jaundice,Photosensitivity reaction,Priapism,Hepatotoxicity
Potentially Fatal: Bone-marrow suppression. Cardiac arrhythmias or aspiration.
Interaction
Additive anticholinergic effects with antihistamines, tricyclic antidepressants and drugs used in parkinsonism. May reduce the antihypertensive effect of guanethidine and other adrenergic neurone blockers. May also increase risk of arrhythmias when used with drugs that prolong QT interval.
Potentially Fatal: Potentiation of other CNS depressants including alcohol, sedatives, hypnotics, barbiturates, opioids, antihistamines and general anaesthetics.
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