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Ursodil 300
General Pharmaceuticals Ltd.
Generic: Ursodeoxycholic Acid
Safety Advices
বাংলা
English
UNSAFE
Ursodil 300 may cause excessive drowsiness with alcohol.
SAFE IF PRESCRIBED
Ursodil 300 is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
SAFE IF PRESCRIBED
Ursodil 300 is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
SAFE
Ursodil 300 does not usually affect your ability to drive.
CONSULT YOUR DOCTOR
There is limited information available on the use of Ursodil 300 in patients with kidney disease. Please consult your doctor.
CONSULT YOUR DOCTOR
There is limited information available on the use of Ursodil 300 in patients with liver disease. Please consult your doctor.
Medicine Overview of Ursodil 300mg Tablet
Introduction
Ursodil 300 is a medicine used to dissolve certain types of gallstones, to prevent them from forming and to treat a type of liver disease called primary biliary cirrhosis. It is a bile acid which helps break down cholesterol which has formed into stones in your gallbladder. Ursodil 300 should be taken after a meal with a glass of milk or water. The dose will depend on what you are being treated for and your body weight. It would be best to swallow it whole. This medicine needs to be taken regularly to get the most benefit and you may...
... Show moreUses of Ursodil 300
- Primary biliary cirrhosis
- Gallbladder stones
Side effects of Ursodil 300
Common
- Abdominal pain
- Diarrhea
- Hair loss
- Itching
- Nausea
- Rash
How to use Ursodil 300
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Ursodil 300 is to be taken with food.
How Ursodil 300 works
Ursodil 300 is a hepatoprotective medication. It works by reducing the amount of cholesterol in the blood and helps dissolve gallbladder stones that are composed mainly of cholesterol. It also improves liver enzymes, protects liver cells from injury caused due to toxic bile acids, and improves liver function.
What if you forget to take Ursodil 300?
If you miss a dose of Ursodil 300, skip it and continue with your normal schedule. Do not double the dose.
Quick Tips
- Ursodil 300 should be taken after a meal with a glass of milk or water.
- Eat a healthy diet, exercise regularly and avoid alcohol intake.
- Diarrhea may occur as a side effect. Drink plenty of fluids and inform your doctor if diarrhea persists or if you find blood in your stools.
- Your doctor may monitor your liver function and bilirubin levels every month for next 3 months after the start of therapy, and every 6 months thereafter.
- Do not stop taking the medication without talking to your doctor.
Brief Description
Indication
Dissolution of cholesterol-rich gallstones, Primary biliary cirrhosis, Prevention of gallstone formation in obese patients experiencing rapid weight loss,
Administration
Should be taken with food.
Adult Dose
Oral
Dissolution of cholesterol-rich gallstones
Adult: 8-12 mg/kg once daily at bedtime or in 2 divided doses continued for 3-4 mth after radiological disappearance of gallstones. Duration of treatment: Up to 2 yr.
Obese patients: Up to 15 mg/kg daily.
Primary biliary cirrhosis
Adult: 10-16 mg/kg daily in 2-4 divided doses, may be taken once daily in the evening after the 1st 3 mth.
Prophylaxis of gallstones in patients undergoing rapid weight loss
Adult: 300 mg bid.
Non-alcoholic fatty liver disease: 13-15 mg/kg/day;
Contraindication
Acute inflammation of gallbladder or biliary tract, occlusion of biliary tract, frequent episodes of biliary colic, radio-opaque calcified gallstones, impaired contractility of gallbladder, non-functioning gallbladder, inflammatory bowel disease, hepatic and intestinal conditions interfering w/ enterohepatic recirculation of bile acids, extrahepatic and intrahepatic cholestasis, ileal resection and stoma, regional ileitis, active duodenal and gastric ulcer; acute, chronic or severe hepatic disease.
Mode of Action
Ursodeoxycholic acid suppresses hepatic synthesis and secretion of cholesterol and also inhibits intestinal absorption of cholesterol.
Precaution
Excessive diatery intake of calories and cholesterol should be avoided. Liver function tests and bilirubin levels should be monitored every month for three months after start of therapy. 50% of successfully treated patients will develop further gallstones within 10 yr. Pregnancy and lactation. Monitoring Parameters Monitor LFTs mthly for the 1st 3 mth and every 6 mth thereafter.
Lactation: unknown if excreted in breast milk; use caution
Side Effect
>10%
Headache,Dizziness,Diarrhea,Dyspepsia,Nausea/vomiting,Back pain,Upper respiratory tract infection
1-10%
Alopecia,Rash,Hyperglycemia,Flatulence,Peptic ulcer,Urinary tract infection,Leukopenia,Thrombocytopenia,Cholecystitis
>1%
Fatigue,Abdominal pain,Thrombocytopenia,Pruritus,Angioedema,Peripheral edema,Biliary pain
Interaction
Cholestyramine, charcoal and antacids may reduce effectiveness. Aluminum-based antacids may reduce absorption. Oestrogens and clofibrate may counteract effectiveness of ursodeoxycholic acid by increasing cholesterol elimination in bile. Possible increase in ciclosporin serum concentration. Decreased effectiveness of dapsone. Possible decrease in serum ciprofloxacin and nitrendipine.
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