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Safety Advices
বাংলা
English
UNSAFE
It is unsafe to consume alcohol with Vextra.
CONSULT YOUR DOCTOR
Vextra may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
CONSULT YOUR DOCTOR
Information regarding the use of Vextra during breastfeeding is not available. Please consult your doctor.
UNSAFE
Vextra may cause side effects which could affect your ability to drive.
SAFE IF PRESCRIBED
Vextra is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Vextra may not be needed in these patients. Please consult your doctor.
CAUTION
Vextra should be used with caution in patients with liver disease. Dose adjustment of Vextra may be needed. Please consult your doctor.
Use of Vextra is not recommended in patients with severe liver disease.
Medicine Overview of Vextra 20mg Tablet
Introduction
Vextra is a pain relieving medicine. It alleviates pain, redness, and swelling in various conditions such as rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis. Vextra can be taken with or without food. The dose and duration will depend on what you are taking it for and how well it helps your symptoms. You should keep taking the medicine even if you feel better until the doctor says it is okay to stop using the medicine. The most common side effects of this medicine include flu-like symptoms, indigestion, abdominal pain, nausea, change in blood pressure, backache, and edema. If any of these...
... Show moreUses of Vextra
- Pain relief
Side effects of Vextra
Common
- Diarrhea
- Flatulence
- Flu-like symptoms
- Peripheral edema
- Stomach pain
How to use Vextra
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Vextra may be taken with or without food, but it is better to take it at a fixed time.
How Vextra works
Vextra is a non-steroidal anti-inflammatory drug (NSAID) called COX-2 inhibitors. It works by blocking the release of certain chemical messengers that are responsible for pain and inflammation (redness and swelling).
Quick Tips
- Vextra helps relieve pain and inflammation.
- It may cause fewer stomach problems as compared to other NSAIDs like Ibuprofen or Naproxen.
- It may cause dizziness and fatigue. Do not drive or do anything requiring concentration until you know how it affects you.
- Do not consume alcohol while on treatment with this medicine as it may cause excessive drowsiness.
- Regularly monitor your blood pressure while taking this medicine, particularly in the first two weeks after starting treatment.
- Inform your doctor if you have a history of stomach ulcers, heart diseases, high blood pressure, and liver or kidney disease.
- During long-term treatment, your doctor may want to take regular blood tests to monitor your liver function.
- Do not take Vextra if you are pregnant, planning to conceive, or breastfeeding.
Brief Description
Indication
Osteoarthritis, Rheumatoid arthritis, Dysmenorrhoea
Administration
May be taken with or without food.
Adult Dose
Oral
Osteoarthritis, Rheumatoid arthritis
Adult: 10 mg once daily.
Dysmenorrhoea
Adult: 20 mg bid.
Hepatic Impairment
Child-Pugh scale 7-9: Initiate with caution. Child-Pugh scale >10: Avoid.
Renal Dose
Renal Impairment
CrCl Dosage
<30 Initiate with caution.
Contraindication
Hypersensitivity to sulfonamides, NSAIDs and other COX 2 inhibitors; asthma, urticaria; severe hepatic impairment; pregnancy (third trimester); lactation. Active GI bleed or ulceration, severe CHF, inflammatory bowel disease.
Mode of Action
Valdecoxib acts by selectively inhibiting prostaglandin synthesis primarily by blocking cyclooxygenase (COX-2) enzyme. It was withdrawn worldwide, following risk of serious skin reactions and cardiovascular side effects.
Precaution
Mild to moderate hepatic impairment; history of ulcer disease or GI bleeding; dehydration, hypertension, history of heart failure, left ventricular dysfunction, pre-existing oedema. Monitor Hb or haematocrit values for signs and symptoms of anaemia.
Side Effect
Hypertension, back pain, myalgia, peripheral oedema, influenza-like symptoms, dizziness, headache, abdominal fullness, abdominal pain, diarrhoea, dyspepsia, flatulence, nausea, myalgia, sinusitis.
Potentially Fatal: Toxic epidermal necrolysis, exfoliative dermatitis.
Interaction
Concomitant admin of aspirin may result in an increased risk of GI ulceration and complications. It decreases the antihypertensive effect of antihypertensives e.g. ACE inhibitors. It increases plasma conc of dextromethorphan. It significantly decreases lithium serum clearance and renal clearance.
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