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Azapin 15
Labaid Pharmaceuticals Ltd.
Generic: Mirtazapine
Safety Advices
বাংলা
English
UNSAFE
It is unsafe to consume alcohol with Azapin 15.
CONSULT YOUR DOCTOR
Azapin 15 may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
CONSULT YOUR DOCTOR
Azapin 15 is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
The baby should be monitored for behavioral side effects and adequate growth.
UNSAFE
Azapin 15 may cause side effects which could affect your ability to drive.
Azapin 15 can affect your concentration or alertness. This may impair your driving ability.
CAUTION
Azapin 15 should be used with caution in patients with kidney disease. Dose adjustment of Azapin 15 may be needed. Please consult your doctor.
CAUTION
Azapin 15 should be used with caution in patients with liver disease. Dose adjustment of Azapin 15 may be needed. Please consult your doctor.
Medicine Overview of Azapin 15mg Tablet
Introduction
Azapin 15 is a prescription medicine used in the treatment of depression. This medicine helps by increasing the level of chemical messengers (serotonin and noradrenaline) in the brain that have a calming effect on the brain and relax the nerves, thus treating your depression. Azapin 15 may be taken with or without food. It is advised to take this medicine at a fixed time each day to maintain a consistent level in the blood. If you miss any doses, take it as soon as you remember. Do not skip any doses and finish the full course of treatment even if...
... Show moreUses of Azapin 15
- Depression
Side effects of Azapin 15
Common
- Sleepiness
- Dryness in mouth
- Increased appetite
- Headache
- Weight gain
How to use Azapin 15
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Azapin 15 may be taken with or without food, but it is better to take it at a fixed time.
How Azapin 15 works
Azapin 15 is an antidepressant. It works by increasing the levels of chemical messengers (serotonin and noradrenaline), natural substances in the brain that help maintain mental balance.
Quick Tips
- Azapin 15 starts to work more quickly than other antidepressants.
- Avoid driving or operating dangerous machinery as it may decrease alertness.
- Avoid consuming alcohol when taking the Azapin 15, as it may cause excessive drowsiness and calmness.
- If your doctor asks you to stop Azapin 15, you should reduce the dose slowly over 4 weeks. You should not discontinue it abruptly.
- Notify your doctor immediately if you develop a sore throat or fever or stomatitis during treatment with Azapin 15.
Brief Description
Indication
Depression, Major depressive disorder
Administration
May be taken with or without food.
Adult Dose
Oral
Depression
Adult: Initially, 15 mg daily; may be increased gradually depending on clinical response. Change dose at intervals of at least 1-2 wk. Usual effective dose: 15-45 mg daily given as single dose, preferably at bedtime, or in 2 divided doses.
Elderly
Depression
7.5 mg/day PO qHS; increase by 7.5-15 mg/day no more frequently than q1-2Weeks; not to exceed 45 mg/day
Alzheimer Dementia-related Depression
7.5 mg/day PO qHS; increase by 7.5-15 mg/day no more frequently than q1-2Weeks; not to exceed 60 mg/day
Hepatic impairment: Clearance is reduced; monitor closely
Child Dose
Safety and efficacy not established
Renal Dose
Renal impairment (CrCl <39 mL/min): Clearance is reduced; monitor closely
Contraindication
Mirtazapine Tablets are contraindicated in patients with a known hypersensitivity to mirtazapine or to any of the excipients.
Mode of Action
Mirtazapine, a piperazinoazepine tetracyclic antidepressant, enhances noradrenergic and serotonergic activity through blockade of central presynaptic adrenergic alpha 2-receptors.
Precaution
Epilepsy or history of seizures; avoid completely in unstable cases. Hepatic or renal impairment, cardiac disorders e.g. conduction disturbances, angina pectoris, recent MI. Hypotension, DM, psychoses, history of bipolar disorder. Stop treatment if jaundice develops. Micturition disturbances, angle-closure glaucoma, raised intraocular pressure. Monitor patient for signs of bone marrow depression. Monitor patient for suicidal tendency. Avoid abrupt withdrawal. May impair ability to drive or operate machinery. Pregnancy and lactation. Elderly.
Lactation: Avoid
Side Effect
>10%
Somnolence (54%),Weight gain (>7% increase in 7% increase in 8% of adults),Dizziness (7%),Serum TGs increased (6%),Dream disorder (4%),Disturbance in thinking (3%),ALT increased (2%),Peripheral edema (2%),Myalgia (2%),Confusion (2%),Urinary frequency (2%),Tremor (2%),Back pain (2%),Dyspnea (1%)
<1%
Mania (0.2%),Grand mal seizure (less than 0.1%)
Frequency Not Defined
Depression exacerbation,Status epilepticus,Suicidal thoughts, suicide (rare),Agranulocytosis,Neutropenia
Interaction
Potentiation of sedative effects with alcohol or benzodiazepines. Increased plasma levels with potent CYP3A4 inhibitors (e.g. HIV-protease inhibitors, azole antifungals including ketoconazole, erythromycin, nefazodone). Reduced plasma levels with carbamazepine and other inducers of CYP3A4. Increased bioavailability with cimetidine.
Potentially Fatal: Do not use with or within 2 wk of stopping an MAOI; at least 1 wk should elapse between discontinuing mirtazapine and initiating any drug which may provoke a serious reaction (e.g. phenelzine).
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