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Vitilen 10
Ziska Pharmaceuticals Ltd.
Generic: Methoxsalen
Safety Advices
বাংলা
English
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Vitilen 10. Please consult your doctor.
CONSULT YOUR DOCTOR
Vitilen 10 is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
CAUTION
Vitilen 10 should be used with caution during breastfeeding. Breastfeeding should be held until the treatment of the mother is completed and the drug is eliminated from her body.
CONSULT YOUR DOCTOR
It is not known whether Vitilen 10 alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react.
CONSULT YOUR DOCTOR
There is limited information available on the use of Vitilen 10 in patients with kidney disease. Please consult your doctor.
CAUTION
Vitilen 10 should be used with caution in patients with liver disease. Dose adjustment of Vitilen 10 may be needed. Please consult your doctor.
Medicine Overview of Vitilen 10mg Capsule
Introduction
Vitilen 10 is a medicine used along with controlled ultraviolet light for effective treatment of certain skin diseases like vitiligo and psoriasis. Vitilen 10 is taken after meals in a dose and duration as advised by the doctor. Taking with food helps to increase absorption of the medication as well as decreases nausea. The dose you are given will depend on your condition and how you respond to the medicine. You should keep taking this medicine for as long as your doctor recommends. If you stop treatment too early your symptoms may come back and your condition may worsen. Let...
... Show moreUses of Vitilen 10
- Vitiligo
- Psoriasis
Side effects of Vitilen 10
Common
- Itching
How to use Vitilen 10
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Vitilen 10 is to be taken with food.
How Vitilen 10 works
Vitilen 10 is a organic compound. It is used along with ultraviolet-A irradiation. It works by decreasing the number of cells the skin makes.
Quick Tips
- Take this treatment (methoxsalen and UVA) two or three times a week with the treatment spaced at least forty-eight hours apart.
- Take this medication by mouth with food or milk, usually 2 to 4 hours before your UVA light treatment.
- Do not sunbathe for 24 hours before taking methoxsalen. Wear UVA-absorbing, wrap-around sunglasses and cover exposed skin or use a sunblock (SP 15 or higher) for the twenty-four (24) hour period following treatment with methoxsalen.
- Use extra caution for at least 48 hours following each treatment. After each treatment, cover your skin for at least 8 hours by wearing protective clothing.
- Do not increase the amount of methoxsalen if you are taking or spend extra time in the sunlight or under an ultraviolet lamp.
- Do not drive or operate machinery as methoxsalen may cause dizziness.
- Not recommended for use in children younger than 12 years.
- You will need to have an eye examination before starting methoxsalen and also once a year thereafter.
Brief Description
Indication
Psoriasis, Vitiligo, Eczema, T-Cell Lymphoma
Administration
Apply over lesions then expose to UVA immediately after application or wait up to 2 hr. Protect the area surrounding the lesion w/ a sunscreen. Wash and protect lesions from light after treatment; protection may be up to >48 hr. Treatment is usually repeated once wkly. Substantial repigmentation usually requires 6-9 mth of treatment.
Adult Dose
Topical
Vitiligo:
Adults and children 12 years of age and over
Apply to the affected area of the skin 2 hr before UV exposure q3-7 days.
The amount and time of UVA light for each treatment is based on skin type and response to treatment. patient may have UVA light treatments 2 to 4 times a week when first start and then less frequently as condition improves.
Child Dose
Topical
Vitiligo:
Children 12 years of age and over
Apply to the affected area of the skin 2 hr before UV exposure q3-7 days.
<12 years old: safety and efficacy not established
Contraindication
Hypersensitivity. Aphakia, existing or history of melanoma, invasive squamous cell carcinoma, photosensitivity diseases (e.g. porphyria, acute lupus erythematosus, xeroderma pigmentosum).
Mode of Action
Methoxsalen increases skin reactivity to long-wavelength UV rays. It bonds covalently to DNA inhibiting DNA synthesis and cell division, which can lead to cell injury. This effect is used in photochemotherapy or PUVA and high-intensity long-wavelength UVA irradiation].
Precaution
Patient exhibiting multiple basal cell carcinoma or history of basal cell carcinoma, previous arsenic therapy, previous x-ray or grenz ray therapy; cardiac diseases or those unable to tolerate prolonged standing or exposure to heat stress; GI diseases or chronic infection. Hepatic impairment. Pregnancy and lactation.
Lactation: not known whether excreted in breast milk; use caution
Side Effect
All Patients
Mild-moderate erythema x 24-48 hrs
1-10%
Nausea,Pruritis
Frequency Not Defined
Edema,Dizziness,Headache,Malaise,Depression,Hypopigmentation,Bullae formation,Rash,Herpes simplex,Uritcaria,GI disturbances,Leg cramps,Hypotension,Extension of psoriasis
Interaction
Additive effects with drugs known to cause photosensitisation e.g. anthralin, coal tar or derivatives, griseofulvin, phenothiazines, nalidixic acid, sulfonamides., tetracyclines and thiazide diuretics. May increase the levels/effects of aminophylline, fluvoxamine, mexiletine, mirtazapine, ropinirole, theophylline, trifluoperazine, dexmedetomidine and ifosfamide.
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