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Xaloplat 100

Infusion-(100mg/vial)
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Beacon Pharmaceuticals PLC

Generic: Oxaliplatin

1 x Infusion
৳ 5010.58
৳ 5500
9% OFF
Alternative Brands For Xaloplat 100

Medicine Overview of Xaloplat 100mg/vial Infusion

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Introduction

Xaloplat 100 is used in the treatment of cancer of colon and rectum. It shows its working by stopping or slowing down the growth of cancer cells. Xaloplat 100 is given as an injection into vein by a qualified medical professional. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to. Nausea, fatigue, vomiting, and diarrhea are some common side effects of this medicine. This medicine may reduce the number of blood cells (decrease red blood and white blood cells) in your blood, thereby, increasing the susceptibility to infections. It may cause some serious allergic reaction, inform your doctor if you notice sore lips or mouth ulcers, rash, itching and difficulty breathing. Regular blood tests are required to check your blood cells along with heart, liver, and blood uric acid levels. Before taking it, tell your doctor if you have heart disease, liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. It makes men infertile, hence men should take doctor advice about the freezing of sperm before the treatment. You must avoid driving after taking this medicine as it may cause dizziness.

Uses of Xaloplat 100

  • Cancer of colon and rectum

Side effects of Xaloplat 100

Common
  • Nausea
  • Fatigue
  • Anemia (low number of red blood cells)
  • Vomiting
  • Diarrhea
  • Decreased white blood cell count (neutrophils)
  • Low blood platelets
  • Increased liver enzymes
  • Peripheral neuropathy (tingling and numbness of feet and hand)
  • Stomatitis (Inflammation of the mouth)

How to use Xaloplat 100

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Xaloplat 100 works

Xaloplat 100 is an anti-cancer medication. It works by damaging the genetic material (DNA and RNA) of the cancer cells which stops their growth and multiplication.

What if you forget to take Xaloplat 100?

If you miss a dose of Xaloplat 100, please consult your doctor.

Quick Tips

  • Xaloplat 100 is given as an injection into veins under the supervision of a doctor.

Brief Description

Indication

Colorectal cancer, Colon cancer

Administration

IV Preparation Reconstitute by adding 10 mL (for 50 mg vial) or 20 mL (for 100 mg vial) of SWI or D5W. Dilute required amount of reconstituted solution in an infusion solution of 250-500 mL of D5W. Do NOT use NS or chloride-containing solutions Do not use aluminum-containing needles or IV administration sets that may come in contact with carboplatin (aluminum can react causing precipitate formation and loss of potency) IV Administration Flush infusion line with D5W prior to administration of oxaliplatin or any concomitant drug Use separate bags for oxaliplatin and leucovorin (administered through Y-site)

Adult Dose

Intravenous Advanced colorectal cancer Adult: Day 1: Oxaliplatin 85 mg/m² IV + leucovorin 200 mg/m² IV infused over 2 hr, THEN 5-FU 400 mg/m² IV bolus over 2-4 minutes, THEN 5-FU 600 mg/m² IV infusion in D5W (500 mL) over 22 hr Day 2: Same regimen WITHOUT oxaliplatin Repeat every 2 weeks Adjuvant therapy in stage III colon cancer Adult: Day 1: Oxaliplatin 85 mg/m² IV + leucovorin 200 mg/m² IV infused over 2 hr, THEN 5-FU 400 mg/m² IV bolus over 2-4 minutes, THEN 5-FU 600 mg/m² IV infusion in D5W (500 mL) over 22 hr Day 2: Same regimen WITHOUT oxaliplatin Every 2 wk; given for 12 cycles, for a total of 6 months Dose Modification If persistent Grade 2 neuropathy, decrease dose to 75 mg/m² If persistent Grade 3 neuropathy, consider discontinuing oxaliplatin After recovery from grade 3/4 GI or grade 3/4 hematological toxicity: Decrease dose to 75 mg/m² , AND decrease 5-FU by 20% (300 mg/m² bolus, 500 mg/m² infusion)

Child Dose

Safety and efficacy not established

Renal Dose

Renal Impairment Exposure of unbound platinum tends to increase in renally impaired patients Mild (CrCl 50-80 mL/min): No dosage adjustment required Moderate (CrCl 30-49 mL/min): No dosage adjustment required Severe (CrCl <30 mL/min): Reduce starting dose

Contraindication

Pregnancy. Peripheral neuropathy with functional impairment. Severe renal impairment.

Mode of Action

Oxaliplatin, a platinum-containing complex similar to cisplatin, is an alkylating agent. After intracellular hydrolysis, the platinum compound binds to DNA forming cross-links which inhibit DNA replication and transcription, resulting in cell death.

Precaution

Should be administered under the supervision of an experienced cancer chemotherapy physician. Use appropriate precautions for handling and disposal. Monitor neurological status and dose should be reduced if symptoms are prolonged or severe. Monitor blood counts during treatment and courses should not be repeated until blood counts have recovered. Caution in elderly, moderate degrees of renal impairment. Avoid using aluminum-containing needles or IV admin sets that may come into contact with oxaliplatin as aluminum has been reported to cause degradation of platinum compounds. Lactation. Lactation: not known if excreted in milk

Side Effect

>10% Peripheral neuropathy (76%),Anemia (64%),Nausea (64%),Fatigue (61%),Diarrhea (46%),Vomiting (37%),Abdominal pain (31%),Constipation (31%),Thrombocytopenia (30%),Fever (25%),Anorexia (20%),Leukopenia (13%),Dyspnea (13%),Cough (11%) 1-10% Edema (10%),Neutropenia (7%),Pharyngolaryngeal dysesthesia (1-2%) <1% Pulmonary fibrosis,Posterior leukoencephalopathy syndrome Frequency Not Defined Anaphylactic-like reaction (uncommon),Pulmonary fibrosis (uncommon) Potentially Fatal: Anaphylaxis, pulmonary fibrosis.

Interaction

May decrease plasma levels of digoxin. May increase risk of toxicity with nephrotoxic drugs. When administered as sequential infusions, taxane derivatives (docetaxel, paclitaxel) should be administered before oxaliplatin to limit myelosuppression and enhance efficacy.

Buy Xaloplat 100 from Arogga

In Bangladesh, you can get the original Xaloplat 100. Select your favorite one from a large collection of medicine products. Order from App to get more offers and better experience.

What is the price of Xaloplat 100 in Bangladesh?

The latest price of Xaloplat 100 in Bangladesh is 5010.58৳. You can buy Xaloplat 100 at the best price from Arogga. Order online through our website or mobile app and get fast home delivery anywhere in Bangladesh. Cash on Delivery (COD) is available all over Bangladesh.

Frequently Questions & Answers

Is the product authentic?

Yes. Arogga sources all medicines and health products directly from trusted suppliers, distributors, or manufacturers. Every product is verified before delivery.

Does Arogga deliver all over Bangladesh?

Yes, Arogga delivers nationwide. You can order from anywhere in Bangladesh.

Is Cash on Delivery(COD) available?

Yes, Cash on Delivery is available across Bangladesh for most products.

How long does delivery take?

Delivery usually takes 24–48 hours inside Dhaka and 3–5 days outside Dhaka, depending on location and courier load.

Can I return or replace the product?

If the product is damaged, incorrect, or expired, you can request a replacement or refund according to Arogga’s return policy.

Safety Advices

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CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Xaloplat 100. Please consult your doctor.
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CONSULT YOUR DOCTOR
Xaloplat 100 is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
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UNSAFE
Xaloplat 100 is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
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UNSAFE
Xaloplat 100 may cause side effects which could affect your ability to drive. Oxaliplatin_name$ treatment may result in an increased risk of dizziness, nausea, and vomiting, and other neurological symptoms that affect walking and this may affect your ability to drive.
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CAUTION
Xaloplat 100 should be used with caution in patients with severe kidney disease. Dose adjustment of Xaloplat 100 may be needed. Please consult your doctor. Limited information is available on the use of Xaloplat 100 in these patients. No dose adjustment is recommended in patients with mild to moderate kidney disease.
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CAUTION
Xaloplat 100 should be used with caution in patients with liver disease. Dose adjustment of Xaloplat 100 may be needed. Please consult your doctor.

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Disclaimer

The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts.