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Xelobine 500
Healthcare Pharmaceuticals Ltd.
Generic: Capecitabine
Safety Advices
বাংলা
English
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Xelobine 500. Please consult your doctor.
CONSULT YOUR DOCTOR
Xelobine 500 is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
UNSAFE
Xelobine 500 is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
UNSAFE
Xelobine 500 may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
CAUTION
Xelobine 500 should be used with caution in patients with kidney disease. Dose adjustment of Xelobine 500 may be needed. Please consult your doctor.
Use of Xelobine 500 is not recommended in patients with severe kidney disease.
CAUTION
Xelobine 500 should be used with caution in patients with liver disease. Dose adjustment of Xelobine 500 may be needed. Please consult your doctor.
Use of Xelobine 500 is not recommended in patients with severe kidney disease.
Medicine Overview of Xelobine 500mg Tablet
Introduction
Xelobine 500 is used in the treatment of cancer of breast, colon, and rectum. It may be also used to treat other conditions, as determined by the doctor. It is used alone or in combination with some other medicine as a part of chemotherapy. Xelobine 500 should be taken with food within 30 minutes after eating a meal. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has...
... Show moreUses of Xelobine 500
- Breast cancer
- Cancer of colon and rectum
Side effects of Xelobine 500
Common
- Vomiting
- Weakness
- Nausea
- Abdominal pain
- Diarrhea
- Blisters on fingers/feet
How to use Xelobine 500
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Xelobine 500 is to be taken with food.
How Xelobine 500 works
Xelobine 500 is an anticancer medication. Inside the body, this medicine gets converted into 5-fluorouracil (chemical). This chemical hampers the synthesis of genetic materials (RNA and DNA) in the cancer cells, thereby interferes with their growth. This slows down the growth of cancer cells and eventually kills them.
Quick Tips
- Xelobine 500 is used alone or in combination with other medicines for the treatment of colon, rectum or breast cancers.
- It is oral chemotherapy, hence it is preferred by many patients.
- It should be taken within 30 minutes after eating a meal.
- The dose and the number of treatment cycles needed will depend on the type and stage of cancer that is being treated.
- It may cause dizziness and tiredness. Don't drive or do anything requiring concentration until you know how it affects you.
- Frequency of hair loss is much less compared to other chemotherapy drugs.
- Do not take it if you are pregnant or breastfeeding.
- Your doctor may regularly monitor your blood cells during treatment with this medicine. Inform your doctor immediately if you notice signs of infection such as fever, sore throat, rash or severe diarrhea.
- Inform your doctor immediately if you start to have side effects such as diarrhea, vomiting, nausea, mouth sores, chest pain or loss of appetite.
Brief Description
Indication
Breast cancer, Colorectal cancer, Gastric cancer, Oesophageal cancer
Administration
Swallow with water within 30 min after a meal
Adult Dose
Oral Breast cancer; Colorectal cancer Adult: 1.25 g/m2 bid for 2 wk followed by a 1 wk rest period; therapy to be given in 3-wk cycles. Recommended treatment duration for colorectal cancer: 6 mth. May be used in combination with docetaxel at 75 mg/m2, given as a 1-hr IV infusion once every 3 wk for the treatment of breast cancer. Gastric cancer Adult: Used in combination with a platinum-based compound, 1 g/m2 bid for 14 days, followed by a 7-day rest period. 1st dose is given on the evening of day 1 and the last dose on the morning of...
... Show moreRenal Dose
Renal impairment:
CrCl (ml/min)
51-80 No adjustment needed.
30-50 Reduce dose to 950 mg/m2 bid when starting dose is 1.25 g/m2 bid. No dose adjustment is needed when starting dose is 1 g/m2.
<30 Avoid use.
Contraindication
History of severe and unexpected reactions to fluoropyrimidine therapy; severe renal impairment; pregnancy, lactation. Hypersensitivity.
Mode of Action
Capecitabine is a prodrug that is converted to fluorouracil following oral administration, which in turn inhibits thymidylate synthetase, blocking the methylation of deoxyuridylic acid to thymidylic acid, interfering with DNA, and to a lesser degree, RNA synthesis.
Precaution
Hepatic dysfunction, bone marrow suppression, poor nutritional status, warfarin therapy. Child, elderly, prior extensive pelvic radiation or alkylating therapy. Moderate renal impairment; CBC with differential; monitor hepatic and renal function. Discontinue use if intractable diarrhoea, stomatitis, bone marrow suppression or MI develops.
Side Effect
10%
Diarrhea,Nausea,Anemia,Lymphopenia,Hand and foot syndrome,Edema,Fatigue,Fever,Headache,Pain,Paresthesia,Alopecia,Dermatitis,Abdominal pain,Anorexia,Appetite decreased,Constipation,Dyspepsia,Stomatitis,Vomiting,Neutropenia,Thrombocytopenia,Dyspnea,Bilirubin increased,Eye irritation
1-10%
Chest pain,Dermatitis,Pruritus,Rash,Dizziness,Headache,Weakness,Dehydration,Dry mouth,Dyspepsia,Taste disturbance,Back pain
Potentially Fatal: Cardiotoxicity, bone-marrow depression and hyperbilirubinaemia.
Pregnancy Category Note
Pregnancy Category: C
Lactation: excretion in milk unknown; use with caution
Interaction
Antacids containing aluminum and magnesium, leucovorin, anticoagulants, phenytoin, allopurinol.
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