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Xenical
Roche Bangladesh Pharmaceutical
Generic: Orlistat
Safety Advices
বাংলা
English
SAFE
Consuming alcohol with Xenical does not cause any harmful side effects.
UNSAFE
Xenical is highly unsafe to use during pregnancy. Seek your doctor's advice as studies on pregnant women and animals have shown significant harmful effects to the developing baby.
SAFE IF PRESCRIBED
Xenical is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.
SAFE
Xenical does not usually affect your ability to drive.
SAFE IF PRESCRIBED
Xenical is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Xenical may not be needed in these patients. Please consult your doctor.
Use of this medicine may be associated with the formation of kidney stones in patients with underlying kidney disease.
SAFE IF PRESCRIBED
Xenical is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Xenical may not be needed in these patients. Please consult your doctor.
Medicine Overview of Xenical 120mg Capsule
Introduction
Xenical is a medicine used in the treatment of obesity. It helps the body in blocking the absorption of fats from the small intestines and stomach. Xenical should be taken along with food in the dose and duration as per prescription. It must be swallowed as a whole. It works best when it is used along with regular physical activity and healthy diet. It should not be taken for a long term unless your doctor tells you to do so. For better efficacy of the medicine, fat-rich foods should be avoided along with the medicine. Some of the common side...
... Show moreUses of Xenical
- Obesity
Side effects of Xenical
Common
- Abdominal pain
- Fat in stool
- Flatus with discharge
- Oily spotting
- Diarrhea
- Abdominal cramp
- Flatulence
- Soft stools
How to use Xenical
Take this medicine in the dose and duration as advised by your doctor. Do not chew, crush or break it. Xenical may be taken with or without food, but it is better to take it at a fixed time.
Avoid Xenical with high-fat meals such as olive oil, nuts & seeds (Brazil nuts), dark chocolate, butter and meat.
How Xenical works
Xenical is a lipase inhibitor. It works in the stomach and small intestine by blocking the absorption of fat from food by blocking enzymes responsible for the breakdown of fat.
Quick Tips
- Xenical is used to aid weight loss in obese individuals.
- It should be used along with regular physical activity and a healthy diet.
- Take it during or up to 1 hour after each meal.
- Skip your dose if you miss a meal or if your meal contains no fat.
- A multivitamin supplement containing vitamins A, D, and K is recommended when taking Xenical.
- It should not be taken for longer than six months. If you have been unable to lose weight after 12 weeks of taking this medicine, you should stop taking it and consult your doctor.
Brief Description
Indication
Obesity
Administration
Should be taken with food. Take immediately before or during or up to 1 hr after each main meal. If a meal is missed or contains no fat, the dose may be omitted.
Adult Dose
Oral
Obesity
Adult:
Indicated in patients with pretreatment BMI >30 kg/m², or BMI >27 kg/m² in presence of other risk factors or diseases (eg, HTN, DM, hyperlipidemia)
120 mg tid w/ each main meal.
Patients w/ BMI >28 kg/m2 irrespective of any risk factors: 60 mg tid.
Omit dose if a meal is missed or contains no fat. Discontinue if patient is unable to lose at least 5% of the body wt during the 1st 12 wk of therapy.
Child Dose
<12 years: Safety and efficacy not established
Contraindication
Chronic malabsorption syndrome. Cholestasis. Lactation
Mode of Action
Orlistat is a reversible gastric and pancreatic lipase inhibitor. It exerts antiobesity effects by limiting the absorption of dietary fats through inhibition of triglyceride hydrolysis. It does not exert appetite suppressant effects.
Precaution
Patient w/ history of hyperoxaluria or Ca oxalate nephrolithiasis. Monitoring Parameters Monitor BMI, diet, LFT, serum glucose (in patient w/ DM), thryroid function (in patient w/ thyroid disease).
Lactation: Not recommended; not known if orlistat is distributed in breast milk
Side Effect
1-10%
Oily spotting (5%)
Frequency Not Defined
Faecal urgency and incontinence, flatulence, fatty stools or discharge, increased defecation; headache, anxiety, fatigue, menstrual irregularities; abdominal pain/discomfort.
Potentially Fatal: Anaphylaxis; angioedema.
Interaction
May decrease absorption of oral fat-soluble vitamins, amiodarone, propafenone. May decrease plasma levels of ciclosporin. May alter the effects of warfarin (monitor INR). May elevate plasma levels of pravastatin.
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