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Xolitra
Beacon Pharmaceuticals PLC
Generic: Flupenthixol + Melitracen
Safety Advices
বাংলা
English
UNSAFE
It is unsafe to consume alcohol with Xolitra.
CONSULT YOUR DOCTOR
Xolitra may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
CONSULT YOUR DOCTOR
Information regarding the use of Xolitra during breastfeeding is not available. Please consult your doctor.
UNSAFE
Xolitra may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
CONSULT YOUR DOCTOR
There is limited information available on the use of Xolitra in patients with kidney disease. Please consult your doctor.
CAUTION
Xolitra should be used with caution in patients with liver disease. Dose adjustment of Xolitra may be needed. Please consult your doctor.
Medicine Overview of Xolitra 500mcg+10mg Tablet
Introduction
Xolitra is a combination of two medicines used in the treatment of depression. This medicine helps by increasing the level of chemical messengers in the brain that have a calming effect on the brain and relax the nerves, thus treating your depression. Xolitra may be taken with or without food, preferably at the same time each day. Take it at the same time each day as this helps to maintain a consistent level of medicine in the body. Take this medicine in the dose and duration as advised by your doctor and if you have missed a dose, take it...
... Show moreUses of Xolitra
- Depression
Side effects of Xolitra
Common
- Constipation
- Urinary retention
- Weight gain
- Sleepiness
- Orthostatic hypotension (sudden lowering of blood pressure on standing)
- Increased heart rate
- Increased prolactin level in blood
- Blurred vision
- Dryness in mouth
- Muscle stiffness
- Tremor
- Restlessness
How to use Xolitra
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Xolitra may be taken with or without food, but it is better to take it at a fixed time.
How Xolitra works
Xolitra is a combination of two medicines: Flupenthixol and Melitracen. Flupenthixol is a typical antipsychotic. It works by blocking the action of dopamine, a chemical messenger in the brain that affects thoughts and mood. Melitracen is a tricyclic antidepressant which increases the levels of chemical messengers in the brain that help in regulating the mood and treat depression.
Quick Tips
- Xolitra helps treat anxiety and depression.
- Use caution while driving or doing anything that requires concentration as Xolitra can cause dizziness and sleepiness.
- Avoid drinking alcohol while taking this medicine because it can make drowsiness worse.
- It can cause changes in your blood sugar levels. Monitor your blood sugar regularly.
- Inform your doctor if you have liver disease, thyroid disorder, severe heart disease, or a urinary disorder.
- Talk to your doctor if you notice sudden mood changes or develop suicidal thoughts.
- Let your doctor know you are taking Xolitra before undergoing any surgical procedure.
Brief Description
Indication
Depression, Anxiety, Apathy, Dysphoria
Adult Dose
Adults: Usually 2 tablets daily; morning and noon. In severe cases the morning dose may be increased to 2 tablets.
Elderly: 1 tablet in the morning.
Maintenance dose: Usually 1 tablet in the morning. In cases of insomnia or severe restlessness additional treatment with a sedative in the acute phase is recommended.
Contraindication
The immediate recovery phase after myocardial infarction, Defects in bundle-branch conduction, Untreated narrow angle glaucoma, Acute alcohol, barbiturate and opiate intoxications, Flupentixol-Melitracen should not be given to patients who have received a MAO-inhibitor within two weeks. Not recommended for excitable or overactive patients since its activating effect may lead to exaggeration of these characteristics.
Mode of Action
Flupentixol is a thioxanthene antipsychotic that inhibits dopamine-mediated effects by blocking postsynaptic dopamine receptors in the CNS.
Melitracen is a TCA with anxiolytic properties.
Precaution
If previously the patient has been treated with tranquilizers with sedative effect these should be withdrawn gradually.
Side Effect
In the recommended doses side effects are rare. These could be transient restlessness and insomnia.
Interaction
May potentiate the adverse effects of drugs with antimuscarinic effects e.g. TCAs. Reduced efficacy of levodopa. Increases adverse extrapyramidal symptoms with dopamine antagonists (metoclopramide and prochlorperazine).
Potentially Fatal: Potentiates CNS effects of alcohol, general anaesthetics, hypnotics, anxiolytics and opioids. Blocks antihypertensive effect of guanethidine.
Additive toxicity with antimuscarinics, CNS depressants. Response to TCA may be accelerated with thyroid hormones; pressor effects of sympathomimetics may be enhanced; risk of serotonin syndrome when taken with other antidepressants. Antidiabetic dosage may need to be adjusted.
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