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Safety Advices
বাংলা
English
UNSAFE
Xonimide may cause excessive drowsiness with alcohol.
CONSULT YOUR DOCTOR
Xonimide may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
CONSULT YOUR DOCTOR
Xonimide is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
UNSAFE
Xonimide may cause side effects which could affect your ability to drive.
As Xonimide may affect your concentration, ability to react/respond, and may make you feel sleepy, particularly at the beginning of your treatment or after your dose is increased.
CAUTION
Xonimide should be used with caution in patients with severe kidney disease. Dose adjustment of Xonimide may be needed. Please consult your doctor.
CONSULT YOUR DOCTOR
There is limited information available on the use of Xonimide in patients with liver disease. Please consult your doctor.
Use of Xonimide is not recommended in patients with severe liver disease.
Medicine Overview of Xonimide 50mg Capsule
Introduction
Xonimide is an anti-epileptic medicine used to treat seizures in epilepsy. It can be used by itself to treat adults or along with other medicines to treat adults and children. It helps to prevent seizures affecting a part or whole of the brain. Xonimide suppresses the abnormal electrical activity in the brain. You can take it with or without food but try to take it at the same time each day to get the most benefit. The dose will depend on your condition and how you respond to the medicine. Your doctor will advise the right dose for you. You...
... Show moreUses of Xonimide
- Epilepsy/Seizures
Side effects of Xonimide
Common
- Dizziness
- Loss of appetite
- Memory impairment
- Drowsiness
- Impaired concentration
- Altered walking
- Impaired coordination
- Anger
How to use Xonimide
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Xonimide may be taken with or without food, but it is better to take it at a fixed time.
How Xonimide works
Xonimide is an antiepileptic medication. It prevents seizures in patients with epilepsy by suppressing the abnormal and excessive activity of the nerve cells in the brain.
What if you forget to take Xonimide?
If you miss a dose of Xonimide, skip it and continue with your normal schedule. Do not double the dose.
Quick Tips
- Take your medication regularly as directed by your doctor as missing doses can trigger seizures.
- Do not change the brand of your medicine and make sure that you have sufficient amount of medicine present with you.
- Some healthy tips to prevent seizures:
- Do not drive or do anything that requires mental focus until you know how this medicine affects you.
- Drink plenty of water while taking Xonimide to reduce the risk of kidney stones and heat stroke. Inform your doctor if you have sudden pain in your stomach, pain on urinating, or if you find blood in your urine.
- It may cause loss of appetite and weight. Monitor your weight regularly.
- Inform your doctor if you develop any unusual changes in mood or behavior, new or worsening depression, or suicidal thoughts or behavior.
- Do not stop taking the medication suddenly without talking to your doctor as it may increase the seizure frequency.
Brief Description
Indication
Adjunct in partial seizures, Monotherapy for partial seizures with or without secondary generalisation
Administration
May be taken with or without food.
Adult Dose
Oral Adjunct in partial seizures Adult: Initially, 50 mg daily in 2 divided doses, increase to 100 mg daily after 1 wk. Thereafter, may further increase dose at wkly intervals in increments of up to 100 mg. Usual maintenance dose: 300-500 mg daily, some patients may respond to lower doses. Monotherapy for partial seizures with or without secondary generalisation Adult: In patients w/ newly diagnosed epilepsy: Initially, 100 mg once daily, increase to 200 mg once daily after 2 wk. May further increase by increments of 100 mg at intervals of at least 2 wk. Usual maintenance dose: 300 mg...
... Show moreChild Dose
Oral
Adjunct in partial seizures
Child: >6 yr Initially, 1 mg/kg once daily for 1 wk, may increase by increments of 1 mg/kg at wkly interval. Usual maintenance dose: 20-55 kg: 6-8 mg/kg once daily; >55 kg: 300-500 mg once daily, some may respond to lower dose.
Renal Dose
Renal impairment: GFR ?50 mL/min: Slower dosage titration may be needed. GFR <50 mL/min: Not recommended.
Contraindication
Hypersensitivity to zonisamide or sulfonamides
Mode of Action
Zonisamide is a benzisoxazole derivative anticonvulsant containing sulfonamide. It may act on voltage sensitive Na and Ca channels, thereby affecting neuronal firing, hence reducing the spread of seizure discharges. It may modulate GABA-mediated neuronal inhibition.
Precaution
Patient at risk of nephrolithiasis. Avoid abrupt withdrawal. Renal or hepatic impairment. Childn. Pregnancy and lactation. Patient Counselling Increase fluid intake (i.e. 6-8 glasses of water/day) to reduce risk of renal stone. This drug may cause drowsiness or difficulty w/ concentration, if affected, do not drive or operate machinery. Increase in suicidal ideation may occur with use.
Monitoring Parameters Monitor metabolic profile specifically BUN, serum creatinine; serum bicarbonate, body temp, suicidality, decreased sweating.
Lactation: Unknown; avoid during breastfeeding
Side Effect
>10%
Somnolence (17%)
Anorexia (13%)
Dizziness (13%)
1-10%
Headache (10%)
Nausea (9%)
Agitation (9%)
Abdominal pain (6%)
Ataxia (6%)
Confusion (6%)
Depression (6%)
Diplopia (6%)
Insomnia (6%)
Diarrhea (5%)
Speech disorder (5%)
Flu-like symptoms (4%)
Kidney stones (4%)
Nystagmus (4%)
Paresthesia (4%)
Dysgeusia (3%)
Weight loss (3%)
Anxiety (3%)
Rash (3%)
Constipation (2%)
Rhinitis (2%)
Xerostomia (2%)
Interaction
Reduced plasma concentration w/ phenytoin, phenobarbital, carbamazepine. Increased risk of metabolic acidosis w/ carbonic anhydrase inhibitors (e.g. acetazolamide).
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