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Zeptol CR 400
Sun Pharmaceutical (Bangladesh) Ltd.
Generic: Carbamazepine
Safety Advices
বাংলা
English
UNSAFE
Zeptol CR 400 may cause excessive drowsiness with alcohol.
CONSULT YOUR DOCTOR
Zeptol CR 400 is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
SAFE IF PRESCRIBED
Zeptol CR 400 is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.
UNSAFE
Zeptol CR 400 may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
CONSULT YOUR DOCTOR
There is limited information available on the use of Zeptol CR 400 in patients with kidney disease. Please consult your doctor.
CONSULT YOUR DOCTOR
There is limited information available on the use of Zeptol CR 400 in patients with liver disease. Please consult your doctor.
Medicine Overview of Zeptol CR 400mg Tablet
Introduction
Zeptol CR 400 is an anti-epileptic medicine used to treat epilepsy. It helps prevent certain types of seizures (fits). It is also prescribed for a painful condition of the face, head, and neck known as trigeminal neuralgia and diabetes-related nerve pain (diabetic neuropathy). Zeptol CR 400 is also occasionally used to treat certain serious mood disorders (eg. bipolar disorder) when other medicines have not worked. The dose and how often you need to take it will be decided by your doctor so that you get the right amount to control your symptoms. It may be increased gradually. Many other medicines...
... Show moreUses of Zeptol CR 400
- Epilepsy/Seizures
- Trigeminal neuralgia
Side effects of Zeptol CR 400
Common
- Balance disorder (loss of balance)
- Dizziness
- Drowsiness
- Nausea
- Slurred speech
- Vomiting
- Blurred vision
- Constipation
- Dryness in mouth
- Fatigue
- Itching
How to use Zeptol CR 400
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Zeptol CR 400 may be taken with or without food, but it is better to take it at a fixed time.
How Zeptol CR 400 works
Zeptol CR 400 is an antiepileptic medication. It controls seizures or fits by decreasing the abnormal and excessive activity of the nerve cells in the brain.
What if you forget to take Zeptol CR 400?
If you miss a dose of Zeptol CR 400, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
- Take your medication regularly as directed by your doctor as missing doses can trigger seizures.
- Do not change the brand of your medicine and make sure that you have sufficient amount of medicine present with you.
- Some healthy tips to prevent seizures:
- It may cause dizziness and sleepiness. Do not drive or do anything that requires mental focus until you know how it affects you.
- Your doctor may get regular tests done to monitor the level of blood cells in your blood while taking this medication.
- Talk to your doctor if you notice sudden mood changes or develop suicidal thoughts.
- Inform your doctor if you notice a rash or other skin changes such as reddish spot or circular patches while taking this medicine.
- Do not stop taking the medication suddenly without talking to your doctor as it may increase the seizure frequency.
Brief Description
Indication
Epilepsy, Schizophrenia, Bipolar disorder, Trigeminal neuralgia
Administration
Should be taken with food. Avoid grapefruit juice.
Adult Dose
Oral Epilepsy Adults - Initial: Either 200 mg b.i.d. for tablets and XR tablets, or 1 teaspoon q.i.d. for suspension (400 mg/day). Increase at weekly intervals by adding up to 200 mg/day using a b.i.d or a t.i.d. or q.i.d. regimen of the either formulations until the optimal response is obtained. Doses up to 1600 mg daily have been used in adults in rare instances. Maintenance: usually 800-1200 mg daily. Trigeminal neuralgia Adult: Initially, 100-200 mg bid, increased gradually as needed. Maintenance: 400-800 mg daily in divided doses. Max: 1.2 g daily. Prophylaxis of bipolar disorder Adult: Initially, 400 mg...
... Show moreChild Dose
Epilepsy
12 Years
Initial (oral suspension): 10 mL (200 mg) PO q6hr
Initial (tablet, immediate- or extended-release): 200 mg PO q12hr
May increase by up to 200 mg/day qWeek; q12hr (extended-release tablet); q6-8hr (other formulations)
12-15 years: Dose not to exceed 1000 mg/day
>15 years: Dose not to exceed 1200 mg/day
Contraindication
Hypersensitivity; bone marrow depression; porphyria, pregnancy.
Mode of Action
Carbamazepine reduces polysynaptic responses and blocks post-tetanic potentiation. It is effective in partial and generalised convulsions as well as in mixed types but not in petit mal seizures. It reduces or abolishes pain in trigeminal and glossopharyngeal neuralgia.
Precaution
Lactation; CV disease, hepatic or renal disorders, history of blood disorders or haematological reactions to other drugs; glaucoma; skin disorders; elderly, patients on MAO inhibitors; abrupt withdrawal of treatment.
Lactation: Enters breast milk; not recommended (AAP states compatible with nursing; however, adverse reactions in breastfeeding infant are possible; take into account the importance of the drug to the mother before deciding to discontinue breastfeeding or the drug)
Side Effect
>10% Ataxia (15%),Dizziness (44%),Drowsiness (32%),Nausea (29%),Vomiting (18%) 1-10% Dry mouth (8%) Rare MI,Stevens-Johnson syndrome Hepatic failure,Punctate cortical lens opacities,Syndrome of inappropriate antidiuretic hormone secretion (SIADH) Frequency Not Defined Hemopoietic system: Aplastic anemia, agranulocytosis, pancytopenia, bone marrow depression, thrombocytopenia, leukopenia, leukocytosis, eosinophilia, anemia, acute intermittent porphyria, variegate porphyria, porphyria cutanea tarda Skin: Toxic epidermal necrolysis (TEN) and Stevens-Johnson syndrome (SJS) (see Black Box Warnings), pruritic and erythematous rashes, urticaria, photosensitivity reactions, alterations in skin pigmentation, exfoliative dermatitis, erythema multiforme and nodosum, purpura, aggravation of disseminated lupus erythematosus, alopecia, diaphoresis, and onychomadesis Cardiovascular system: Congestive heart failure, edema, aggravation of hypertension, hypotension,...
... Show morePregnancy Category Note
Pregnancy category: D
Lactation: Enters breast milk; not recommended (AAP states compatible with nursing; however, adverse reactions in breastfeeding infant are possible; take into account the importance of the drug to the mother before deciding to discontinue breastfeeding or the drug)
Interaction
Increased plasma levels w/ CYP3A4 inhibitors (e.g. cimetidine). Decreased plasma levels w/ CYP3A4 inducers (e.g. cisplatin). Increased risk of neurotoxic side effects w/ lithium. May decrease the effect of hormonal contraceptives. Increased plasma levels of active metabolite carbamazepine-10, 11-epoxide w/ loxapine, quetiapine, primidone, progabide, valproic acid and valpromide. May increase cyclophosphamide levels. May reduce exposure of aripiprazole. May reduce plasma levels of tacrolimus, temsirolimus and lapatinib. May increase risk of isoniazid-induced hepatotoxicity. Risk of symptomatic hyponatraemia w/ diuretics (e.g. hydrochlorothiazide, furosemide). Potentially Fatal: May decrease serum concentrations of nefazodone and its active metabolites. Toxic reactions may develop when taken concurrently...
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