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Azisan Plus
Renata Limited
Generic: Azilsartan + Chlorthalidone
Safety Advices
বাংলা
English
UNSAFE
Azisan Plus may cause excessive drowsiness with alcohol.
CONSULT YOUR DOCTOR
Azisan Plus is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
SAFE IF PRESCRIBED
Azisan Plus is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.
UNSAFE
Azisan Plus may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
CAUTION
Azisan Plus should be used with caution in patients with severe kidney disease. Dose adjustment of Azisan Plus may be needed. Please consult your doctor.
Use of Azisan Plus is not recommended in these patients.
CAUTION
Azisan Plus should be used with caution in patients with liver disease. Dose adjustment of Azisan Plus may be needed. Please consult your doctor.
Use of Azisan Plus is not recommended in patients with severe liver disease.
Medicine Overview of Azisan Plus 40mg+12.5mg Tablet
Introduction
Azisan Plus is a combination medicine used in the treatment of hypertension (high blood pressure). It works by relaxing the blood vessels and making the heart more efficient at pumping blood throughout the body. It also removes extra water and certain electrolytes from the body. Azisan Plus can be taken with or without food, but take it at the same time to get the most benefit. It should be taken as your doctor's advice. The dose and how often you take it depends on what you are taking it for. Never skip any doses and finish a full course of...
... Show moreUses of Azisan Plus
- Hypertension (high blood pressure)
Side effects of Azisan Plus
Common
- Dizziness
- Tiredness
- Decreased potassium level in blood
- Decreased blood pressure
- Increased creatinine level in blood
- Increased uric acid level in blood
How to use Azisan Plus
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Azisan Plus may be taken with or without food, but it is better to take it at a fixed time.
How Azisan Plus works
Azisan Plus is a combination of two medicines: Azilsartan medoxomil and Chlorthalidone which lower blood pressure effectively. Azilsartan medoxomil is an angiotensin receptor blocker (ARB). It works by blocking the hormone angiotensin thereby relaxing blood vessels.This allows the blood to flow more smoothly and the heart to pump more efficiently. Chlorthalidone is a diuretic that removes extra water and certain electrolytes from the body. Over time it also relaxes blood vessels and improves blood flow.
Quick Tips
- You have been prescribed Azildac CT Tablet for the treatment of high blood pressure.
- It can be taken with or without food.
- Azildac CT Tablet may cause dehydration. Drink plenty of fluids and inform your doctor if you develop extreme thirst, very dry mouth or muscle weakness.
- It may cause dizziness. Get up slowly when rising from a sitting or lying position.
- Use of Azildac CT Tablet during pregnancy or breastfeeding is unsafe.
- It may also decrease the risk of stroke and heart attacks.
Brief Description
Indication
Hypertension, Treatment of hypertension in patients not adequately controlled with monotherapy or as initial therapy in patients likely to need multiple drugs to help achieve blood pressure goals
Administration
May be taken with or without food.
Adult Dose
Adult
Oral
Hypertension
1 tab (40 mg/12.5 mg) once daily.
May increase to 40 mg/25 mg after 2-4 weeks as needed to achieve blood pressure goals; not to exceed 40 mg/25 mg daily
Switching from ARB or diuretic monotherapy: Initiate with 40 mg/12.5 mg PO qDay
Hepatic impairment
Mild-to-moderate: No dose adjustment required for azilsartan
Severe: Azilsartan has not been studied in patients with severe hepatic impairment
Chlorthalidone may cause mild alterations of fluid and electrolyte balance that may precipitate hepatic coma in patients with impaired hepatic function or progressive liver disease
Child Dose
Safety and efficacy not established
Renal Dose
Renal impairment
Mild-to-moderate (eGFR 30 mL/min/1.73 sq.meter or greater): No dose adjustment required
Severe (eGFR <30 mL/min/1.73 sq.meter): Safety and effectiveness not established
Chlorthalidone may precipitate azotemia
Contraindication
Hypersensitivity. Patient w/ anuria. Concomitant use w/ aliskiren in patients w/ diabetes. Pregnancy.
Mode of Action
Angiotensin II blocker; displaces angiotensin II from AT1 receptor and may lower blood pressure by antagonizing AT1-induced vasoconstriction, aldosterone release, catecholamine release, arginine vasopressin release, water absorption, and hypertrophic responses
Chlorthalidone produces diuresis with increased excretion of sodium and chloride at the cortical diluting segment of the ascending limb of Henle’s loop of the nephron
Precaution
Hyperuricemia Hyperuricemia may occur or frank gout may be precipitated in certain patients receiving chlorthalidone or other thiazide diuretics Fetal toxicity When pregnancy is detected, discontinue as soon as possible; drugs affecting renin-angiotensin system causing oligohydramnios, which may result in fetal injury and/or death Hypotension in volume or salt depleted patients Electrolytes Hypokalemia is a dose-dependent adverse reaction that may develop with chlorthalidone; Edarbyclor attenuates chlorthalidone-associated hypokalemia Coadministration of digitalis may exacerbate adverse effects of hypokalemia Thiazide diuretics can cause hyponatremia and hypokalemia; drugs that inhibit the renin angiotensin system can cause hyperkalemia; monitor serum electrolytes periodically Lactation: Unknown whether...
... Show moreSide Effect
1-10%
Dizziness (8.9%)
Fatigue (2%)
Hypotension (1.7%)
<1%
Syncope (0.3%)
Pregnancy Category Note
Pregnancy Category: D
Discontinue as soon as possible when pregnancy is detected; use during second and third trimesters affects renin-angiotensin system causing oligohydramnios, which may result in fetal injury and/or death (see Black Box Warnings and Cautions)
Lactation: Unknown whether azilsartan distributed in breast milk, thiazide-like diuretics are excreted in human milk; consider alternate antihypertensive therapy or do not breastfeed
Interaction
Elderly, vol-depleted patients or w/ compromised renal function, co-administration of NSAIDs, including selective COX-2 inhibitors, w/ angiotensin II receptor antagonists (including azilsartan) may result in deterioration of renal function, including possible acute renal failure. Dual blockade of the renin angiotensin system w/ angiotensin receptor blockers, ACE inhibitors or aliskiren is associated w/ increased risks of hypotension, hyperkalemia & changes in renal function (including acute renal failure). Concomitant use w/ aliskiren. Reduced lithium clearance by diuretics eg, chlorthalidone increasing the risk of lithium toxicity.
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