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Safety Advices
বাংলা
English
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Zocil 50. Please consult your doctor.
CONSULT YOUR DOCTOR
Zocil 50 may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
CONSULT YOUR DOCTOR
Zocil 50 is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
UNSAFE
Zocil 50 may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
CAUTION
Zocil 50 should be used with caution in patients with severe kidney disease. Dose adjustment of Zocil 50 may be needed. Please consult your doctor.
CAUTION
Zocil 50 should be used with caution in patients with liver disease. Dose adjustment of Zocil 50 may be needed. Please consult your doctor.
Use of Zocil 50 is not recommended in patients with moderate and severe liver disease as the information available in these patients is limited.
Medicine Overview of Zocil 50mg Tablet
Introduction
Zocil 50 is used in the treatment of pain in legs due to insufficient blood flow (intermittent claudication). It also helps in reducing cramping, numbness, or weakness in the legs that occurs on walking in such patients. Zocil 50 should be taken regularly as advised by the doctor. You should take it on an empty stomach and at a fixed time. This medicine should not be stopped abruptly without consulting the doctor. It may cause side effects like headache, edema, nausea, diarrhea, dizziness and chest pain. Use of this medicine may increase your risk of bleeding. Let your doctor know...
... Show moreUses of Zocil 50
- Intermittent claudication
Side effects of Zocil 50
Common
- Headache
- Palpitations
- Abnormal stool
- Diarrhea
- Dizziness
- Chest pain
- Loss of appetite
- Bleeding
- Rash
How to use Zocil 50
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Zocil 50 is to be taken empty stomach.
How Zocil 50 works
Zocil 50 widens the blood vessels and decreases the stickiness of the platelets, thereby increasing the blood flow to the lower limbs.
What if you forget to take Zocil 50?
If you miss a dose of Zocil 50, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
- Take it at least half an hour before or two hours after breakfast and dinner.
- It may take up to 12 weeks before your symptoms improve. Keep using the medication as directed.
- Consult your doctor, if your symptoms do not improve after 4 weeks of treatment.
- It may cause dizziness. Don't drive or do anything that requires mental focus until you know how it affects you.
- Do not take it if you have heart failure, persistent chest pain at rest, or have had a heart attack or any heart surgery in the last six months.
Brief Description
Indication
Peripheral vascular disease, Intermittent claudication
Administration
Should be taken on an empty stomach. Take at least ½ hr before or 2 hr after meals.
Adult Dose
Oral
Peripheral vascular disease
Adult: 100 mg bid.
May reduce dose in patients taking enzyme inhibitors concurrently.
Hepatic Impairment
Moderate to severe: Use caution
Renal Dose
Renal Impairment
CrCl< 25 mL/min: Use caution
Contraindication
Heart failure; known predisposition to bleeding; history of ventricular arrhythmias; QT interval prolongation; severe renal impairment; moderate to severe hepatic impairment.
Mode of Action
Cilostazol is a reversible, selective inhibitor of phosphodiesterase-III (PDE-III), thereby suppressing cyclic adenosine monophosphate (cAMP) degradation. Increase in cAMP in platelets and blood vessels leads to inhibition of platelet aggregation and vasodilation. Cilostazol also inhibits adenosine uptake into cells, which augments the cAMP-elevating effect of PDE-III inhibition.
Precaution
Congestive heart disease. Concurrent therapy with clopidogrel has not been studied for safety or efficacy. Pregnancy and lactation.
Lactation: Excretion in milk unknown; not recommended
Side Effect
>10%
Headache (27-34%),Diarrhea (12-19%),Abnormal stools (12-15%),Infection (10-14%),Rhinitis (7-12%),Pharyngitis (7-10%)
1-10%
Dizziness (9-10%),Palpitations (5-10%),Peripheral edema (7-9%),Back pain (6-7%),Dyspepsia (6%),Abdominal pain (4-5%),Tachycardia (4%),Increased cough (3-4%),Myalgia (2-3%),Atrial fibrillation (<2%),CHF (<2%),MI (<2%),Hematemesis (<2%),Ecchymosis (<2%),Blood in eye (<2%),Epistaxis (<2%),Hemoptysis (<2%),Nausea
Frequency Not Defined
Decreased platelet aggregation,Agranulocytosis,Aplastic anemia,Leukopenia,Thrombocytopenia,Stevens-Johnson syndrome
Pregnancy Category Note
Pregnancy category: C
Lactation: Excretion in milk unknown; not recommended
Interaction
Co-admin with drugs that affect CYP3A4 (erythromycin, other macrolides, diltiazem) or CYP2C19 (omeprazole) may influence the pharmacokinetics of cilostazol.
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