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Safety Advices
বাংলা
English
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Zolomide. Please consult your doctor.
CONSULT YOUR DOCTOR
Zolomide is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
UNSAFE
Zolomide is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
UNSAFE
Zolomide may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
SAFE IF PRESCRIBED
Zolomide is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Zolomide may not be needed in these patients. Please consult your doctor.
Cautious use is advised in patients with severe kidney disease while they are taking Zolomide.
CAUTION
Zolomide should be used with caution in patients with severe liver disease. Dose adjustment of Zolomide may be needed. Please consult your doctor.
Limited information is available on the use of Zolomide in these patients. No dose adjustment is recommended in patients with mild to moderate liver disease.
Medicine Overview of Zolomide 250mg Capsule
Introduction
Zolomide is used in the treatment of a specific type of cancer of the brain. It is used to treat brain tumors if they return or get worse after standard treatment. It may be also used to treat other conditions, as determined by the doctor. Zolomide should be taken empty stomach and at same time each day to make sure it has the best effect. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should...
... Show moreUses of Zolomide
- Brain tumor
Side effects of Zolomide
Common
- Nausea
- Vomiting
- Constipation
- Headache
- Fatigue
- Convulsion
- Coordination disorder
- Diarrhea
- Dizziness
- Fever
- Hair loss
- Hemiparesis (weakness on one side of the body)
- Insomnia (difficulty in sleeping)
- Loss of appetite
- Memory loss
- Rash
- Viral infection
- Weakness
How to use Zolomide
Take this medicine in the dose and duration as advised by your doctor. Do not chew, crush or break it. Zolomide is to be taken empty stomach.
How Zolomide works
Zolomide is an anti-cancer medication. It enters the brain tissues and works by damaging the genetic material (DNA and RNA) of the cancer cells. This stops their growth and multiplication.
What if you forget to take Zolomide?
If you miss a dose of Zolomide, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
- Swallow full tablets on an empty stomach, one hour before your meal.
- Avoid being near people who are sick or have infections. Consult your doctor if you develop symptoms of opportunistic infections (such as Pneumocystis jirovecii pneumonia) and reactivation of infections (such as hepatitis B virus) Using temozolomide may increase your risk of developing certain types of bone marrow cancer. Be aware about your specific risk.
- You may be given medication to prevent nausea or other side effects while you are receiving temozolomide.
- Your blood will be tested frequently during treatment to monitor the side effects of temozolomide on your blood cells as you may have a small risk of other changes in blood cells, including leukemia.
- Avoid activities that may increase your risk of bleeding or injury. Use extra care to prevent bleeding while shaving or brushing your teeth.
- Do not drink alcohol while taking temozolomide.
- Do not drive or operate machinery while using temozolomide as it may make you tired or sleepy.
- Both male and female patients should take effective contraceptive precautions during and after 6 months of treatment. Male patients should seek advice on conservation of sperm prior to treatment as temozolomide treatment may cause infertility.
Brief Description
Indication
Glioblastoma multiforme, Malignant gliomas, Metastatic melanoma
Administration
Should be taken on an empty stomach. Take on an empty stomach at least 1 hr before meals.
Swallow capsules whole with a full glass of water on an empty stomach or at bedtime. Do not take a 2nd dose if capsules are vomited.
Adult Dose
Oral Glioblastoma multiforme Adult: 75 mg/m2 once daily for 42 days with focal radiotherapy (concomitant phase). Do not reduce dose during concomitant phrase but interrupt or discontinue therapy depending on toxicity. Continue if absolute neutrophil count (ANC)> 1.5x109/L, thrombocyte count >100x109/L and Common Toxicity Criteria (CTC) non-haematological toxicity 1.5x109/L, thrombocyte count >100x109/L and CTC non-haematological toxicity for cycle 1 is 1500 mm³ and platelets >100,000 mm³ Infuse IV over 90 minutes Dosage modifications Measure ANC and platelet on days 22 & 29 (day 1 of next cycle); modify dose for following cycle if: ANC 1000-1500/mm³ or platelet 50,000-100,000/mm³: Postpone treatment...
... Show moreChild Dose
Oral
Recurrent or progressive malignant gliomas
Child: >3 yr: Previously untreated with chemotherapy: 200 mg/m2 once daily for 5 days, followed by a 23 day break (1 cycle).
Previously treated with chemotherapy: 150 mg/m2 daily for 5 days followed by 23 day break (1 cycle) increased to 200 mg/m2 for the 2nd cycle if there is no haematological toxicity.
Contraindication
Hypersensitivity to dacarbazine. Severe myelosupression. Pregnancy.
Mode of Action
Temozolomide, a triazene, is an inactive prodrug. It is chemically hydrolysed to 3-methyl-(triazen-1-yl) imidazole-4-carboxamide (MTIC), the active metabolite of dacarbazine. The cytotoxicity of MTIC is believed to be due alkylation of DNA, mainly at the O6 and N7 positions of guanine.
Precaution
Severe hepatic and renal impairment. Elderly >70 yr, children. Women of child bearing potential should avoid becoming pregnant during therapy. Males should be advised not to father a child up to 6 mth after treatment and to consider cryoconservation of sperms due to possibility of irreversible infertility. May impair ability to drive or operate machinery. Monitor CBC wkly during concomitant therapy and on day 22 of each 28 day treatment cycle, followed by wkly blood count until recovery. Hepatitis screening and prophylactic therapy with antiviral agents as clinically indicated to be considered. Prophylaxis for Pneumocystis jiroveci (or Pneumocystis carinii) pneumonia...
... Show moreSide Effect
>10%
Alopecia (55-69%),Lymphopenia (55%),Nausea (53%),Vomiting (42%),Headache (41%),Fatigue (34%),Constipation (33%),Anorexia (9-27%),Convulsions (23%),Thrombocytopenia (19%),Rash (8-19%),Hemiparesis (18%),Diarrhea (16%),Neutropenia (14%),Fever (13%),Asthenia (13%),Dizziness (12%),Peripheral edema (11%),Viral infections (11%)
1-10% (selected)
Amnesia (10%),Insomnia (10%),Abdominal pain (5-9%),Ataxia (8%),Back pain (8%),Paresis (8%),URI (8%),Urinary incontinence (8%),UTI (8%),Abnormal vision (5-8%),Pruritus (5-8%),Breast pain (6%),Depression (6%),Confusion (5%),Myalgia (5%),Weight gain (5%),Anemia (4%),Erythema (1%)
Interaction
Valproic acid, other myelosuppressive agents.
