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Zybex SR
Beximco Pharmaceuticals Ltd.
Generic: Bupropion Hydrochloride
Safety Advices
বাংলা
English
UNSAFE
Zybex SR may cause excessive drowsiness with alcohol.
CONSULT YOUR DOCTOR
Zybex SR may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
CONSULT YOUR DOCTOR
Zybex SR is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
UNSAFE
Zybex SR may cause side effects which could affect your ability to drive.
Zybex SR may cause dizziness or light-headedness, may affect your concentration and judgement. This may affect your driving ability.
CAUTION
Zybex SR should be used with caution in patients with kidney disease. Dose adjustment of Zybex SR may be needed. Please consult your doctor.
CAUTION
Zybex SR should be used with caution in patients with liver disease. Dose adjustment of Zybex SR may be needed. Please consult your doctor.
Caution is advised for the use of Zybex SR in these patients with close monitoring from a doctor for any possible side effects.
Medicine Overview of Zybex SR 150mg Tablet
Introduction
Zybex SR is a prescription medicine used in the treatment of depression and smoking addiction. This medicine helps by increasing the level of chemical messengers in the brain that relax the nerves and have a calming effect on the brain. Zybex SR may be taken with or without food. It is advised to take this medicine at a fixed time each day. You should never skip any doses and finish the full course of treatment even if you feel better. It is important that this medication is not stopped suddenly as it may worsen your symptoms. Some common side effects...
... Show moreUses of Zybex SR
- Depression
- Smoking addiction
Side effects of Zybex SR
Common
- Insomnia (difficulty in sleeping)
- Allergic reaction
- Impaired concentration
- Sweating
- Headache
- Nausea
- Vomiting
- Dizziness
- Dryness in mouth
- Taste change
- Abdominal pain
- Agitation
- Anxiety
- Fever
- Constipation
- Tremor
How to use Zybex SR
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Zybex SR may be taken with or without food, but it is better to take it at a fixed time.
How Zybex SR works
Zybex SR works in depression by increasing the levels of chemical messengers in the brain that helps in regulating mood. The mechanism underlying its use in smoking addiction are not fully understood.
What if you forget to take Zybex SR?
If you miss a dose of Zybex SR, skip it and continue with your normal schedule. Do not double the dose.
Quick Tips
- You have been prescribed Bupron XL 150 Tablet for the treatment of depression.
- It can also help you quit smoking.
- Take it in the morning to avoid difficulty sleeping later that night.
- It causes fewer side effects as compared to other anti-depression medications.
- Stop taking Bupron XL 150 Tablet and inform your doctor if you notice sudden mood and behavior changes or develop suicidal thoughts.
- Inform your doctor if you have a history of seizure disorder, eating disorder, or if you drink alcohol.
Brief Description
Indication
Depression, smoking cessation
Administration
Swallow extended/sustained-release tablets whole; do not chew, crush, or split; this may lead to adverse effects including seizures
Adult Dose
Oral Smoking cessation Adult: Modified-release preparation: Initially, 150 mg once daily for 6 days then increased to 150 mg bid. Period of treatment: 7-12 wk. To discontinue treatment if abstinence is not achieved by 7th wk. Max: 300 mg/day. Elderly: 150 mg/day. Hepatic impairment: Mild to moderate: 150 mg once daily. Severe hepatic cirrhosis: Contraindicated. Depression Adult: Initially, 100 mg bid increased to 100 mg tid after 3 days if necessary. Increased further to 150 mg tid if no improvement has been observed after several wk of therapy. Max: 150 mg tid. As a modified-release preparation: 150 mg once daily...
... Show moreRenal Dose
Renal impairment: Use caution; consider dose reduction
Contraindication
It is contraindicated in patients with a seizure disorder. Bupropion Hydrochloride is contraindicated in patients treated with other medications that contain Bupropion because the incidence of seizure is dose dependent. Bupropion may induce seizure and consequently its use is contraindicated in patients with epilepsy. The drug is also contraindicated in patients with a current or prior diagnosis of bulimia or anorexia nervosa because of a higher incidence of seizures noted in such patients treated for bulimia with Bupropion Hydrochloride. The concurrent administration of Bupropion Hydrochloride and a monoamine oxidase (MAO) inhibitor is contraindicated. At least 14 days should elapse between...
... Show moreMode of Action
Bupropion HCl is a relatively weak inhibitor of the neuronal uptake of norepinephrine, serotinin and dopamine. The mechanism by which it aids in smoking cessation is presumed to be mediated by its noradrenergic and/or dopaminergic actions.
Precaution
It should be used with extreme caution, in patients with history of seizure disorders or in patients with other predisposing factors such as severe hepatic cirrhosis or a CNS tumour, and in those undergoing abrupt withdrawal from alcohol or Benzodiazepines. The use of Bupropion in patients with other risk factors for seizures (for example, alcohol abuse, a history of head trauma, diabetes, and drugs known to lower the seizure threshold) should only be undertaken when there are compelling clinical reasons. Bupropion should be used with caution in patients with bipolar depression or psychoses and in patients with a recent history...
... Show moreSide Effect
>10%
Headache (25-34%),Dry mouth (17-28%),Nausea (1-18%),Weight loss (15-20%),Insomnia (11-20%),Agitation (2-32%),Dizziness (6-22%),Pharyngitis (3-13%)
1-10%
Constipation (5-10%),Infection (8-9%),Abdominal pain (2-9%),Anxiety (5-7%),Diarrhea (5-7%),Tinnitus (3-6%),Tremor (3-6%),Nervousness (3-5%),Anorexia (3-5%),Palpitation (2-6%),Myalgia (2-6%),Sweating (2-5%),Rash (1-5%),Sinusitis (1-5%),Weight gain (4%),Chest pain (3-4%),Urinary frequency (2%),Vaginal hemorrhage (2%),Pruritus (2-4%),Vomiting (2-4%),Arthralgia (1-4%),Flushing (1-4%),Migraine (1-4%),Decreased memory (3% [>450 mg/day]; may be increased risk with concomitant ECT)
Frequency Not Defined
Confusion,Cystitis,Erythema,,Ataxia,Coma,EEG abnormality,Euphoria,Gastric reflux
Pregnancy Category Note
Pregnancy Data from epidemiological studies of pregnant women exposed to bupropion in first trimester have not identified an increased risk of congenital malformations overall; there are risks to the mother associated with untreated depression in pregnancy A prospective, longitudinal study followed 201 pregnant women with a history of major depressive disorder who were euthymic and taking antidepressants during pregnancy at beginning of pregnancy; the women who discontinued antidepressants during pregnancy were more likely to experience a relapse of major depression than women who continued antidepressants; consider risks to the mother of untreated depression and potential effects on tfetus when discontinuing...
... Show moreInteraction
Neuroleptics, lithium and TCAs, benzodiazepine, alcohol, drugs that lower seizure threshold. Increased risk of side effects when co-admin with levodopa. Reduced hepatic clearance with fluoxetine. Caution when administering with agents that will affect hepatic drug metabolizing enzymes. Increased risk of toxicity when used with ritonavir.
Potentially Fatal: Concurrent use with MAO inhibitors may cause acute toxicity symptoms and increased risk of fatality.
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