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Zydus 400
Healthcare Pharmaceuticals Ltd.
Generic: Moxifloxacin
Safety Advices
বাংলা
English
CONSULT YOUR DOCTOR
Zydus 400 may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
CONSULT YOUR DOCTOR
Zydus 400 is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
UNSAFE
Zydus 400 may cause side effects which could affect your ability to drive.
Zydus 400 may make you feel dizzy or light-headed, you may experience a sudden, transient loss of vision, or you may faint for a short period. This may affect your driving ability.
Medicine Overview of Zydus 400mg Tablet
Introduction
Zydus 400 is an antibiotic, used in the treatment of bacterial infections of the eye. It relieves the symptoms of the infection by stopping the further growth of the causative microorganisms. Zydus 400 is for external use only. Take it in the dose and duration as advised by your doctor. Hold the dropper close to the eye without touching it. Gently squeeze the dropper and place the medicine inside the lower eyelid. Wipe off extra liquid. Avoid skipping any doses and finish the full course of treatment even if you feel better. It may cause eye discomfort, dry eyes and...
... Show moreUses of Zydus 400
- Bacterial eye infections
Side effects of Zydus 400
Common
- Eye discomfort
- Dry eye
- Burning sensation
How to use Zydus 400
This medicine is for external use only. Take it in the dose and duration as advised by your doctor. Check the label for directions before use. Hold the dropper close to the eye without touching it. Gently squeeze the dropper and place the medicine inside the lower eyelid. Wipe off extra liquid.
How Zydus 400 works
Zydus 400 is an antibiotic. It treats bacterial eye infections by preventing the bacteria from dividing and repairing. It does so stopping the action of a bacterial enzyme called DNA-gyrase.
What if you forget to take Zydus 400?
If you miss a dose of Zydus 400, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
- You have been prescribed Zydus 400 for the treatment of bacterial infections of the eye.
- Do not skip any doses and finish the full course of treatment even if you feel better.
- Apply pressure on the corner of the eye (close to the nose) for about 1 minute, immediately after instilling the medication.
- Do not touch the tip to any surface, or to your eye, to avoid contamination.
- Wait for at least 5-10 minutes before delivering the next medication in the same eye to avoid dilution.
- It may cause short term blurring of vision when first used. Use caution before driving or using machines.
- Do not wear contact lenses until your infection clears up.
- Make sure to use within 4 weeks of opening the medication.
Brief Description
Indication
Community Acquired Pneumonia, Acute Bacterial Exacerbation of Chronic Bronchitis, Acute Bacterial Sinusitis, Complicated Intra-Abdominal Infection, Uncomplicated Skin and Skin Structure Infections, Complicated Skin and Skin Structure Infections, Typhoid Fever.
Administration
May be taken with or without food.
Adult Dose
Oral The dose of Moxifloxacin is 400 mg once every 24 hours. The duration of therapy depends on the type of infection as described bellow Acute Bacterial Sinusitis 400 mg is given once daily for 10 days. Acute Bacterial Exacerbation of Chronic Bronchitis 400 mg is given once daily for 5 days. Community Acquired Pneumonia 400 mg is given once daily for 7-14 days. Uncomplicated Skin & Skin Structure infections 400 mg is given once daily for 7 days. Complicated Skin & Skin Structure infections 400 mg is given once daily for 7-21 days. Complicated Intra-Abdominal infections 400 mg is...
... Show moreChild Dose
<18 years: Safety and efficacy not established
Contraindication
Known hypersensitivity to moxifloxacin, other quinolones. Patients w/ known prolongation of QT interval, uncorrected hypokalaemia, myasthenia gravis. Concurrent use of class Ia (e.g.quinidine, procainamide, class III (e.g. amiodarone, sotalol) antiarrhythmic drugs or w/ other drugs that prolong QT interval (e.g. erythromycin, TCAs, antipsychotic agents).
Mode of Action
Moxifloxacin inhibits the topoisomerase II (DNA gyrase) and topoisomerase IV required for bacterial DNA replication, transcription, repair and recombination.
Precaution
Maintain adequate fluid intake; Patient w/ previous tendon disorders (e.g. rheumatoid arthritis), significant bradycardia or acute myocardial ischaemia, heart failure w/ reduced LVEF, known history of symptomatic arrhythmias, known or suspected CNS disorders (e.g. severe cerebral arteriosclerosis, epilepsy) or other risk factors that predispose to seizures; diabetes. Kidney, heart or lung transplant recipients. Hepatic impairment. Pregnancy and lactation. Patient Counselling This drug may cause dizziness and lightheadedness, if affected do not drive or operate machinery. Rest and refrain from doing strenuous physical activity as it may increase risk of tendon rupture. Avoid exposure to sunlight or artificial UV light (e.g....
... Show moreSide Effect
1-10%
Nausea (7%),Diarrhea (6%),Dizziness (3%),Decreased amylase (2%),Decreased basophils, eosinophils, hemoglobin, prothrombin time, red blood cells, neutrophils (2%),Decreased serum glucose (2%),Increased serum chloride (2%),Increased serum ionized calcium (2%),Immune hypersensitivity reaction (0.1-2%),Prolonged QT interval (0.1-2%)
<1%
Acute renal failure,Agranulocytosis,Anaphylactoid reaction,Aplastic anemia,Extrinsic allergic alveolitis,Hemolytic anemia,Hepatic failure,Hepatic necrosis,Hepatitis,Pancytopenia,Seizure,Serum sickness due to drug,Stevens-Johnson syndrome,Tendon rupture, tendinitis,Thrombocytopenia,Torsades de pointes,Toxic epidermal necrolysis
Interaction
Additive effect on QT interval prolongation w/ other drugs that prolong QT interval (e.g. erythromycin, TCAs, antipsychotic agents). Decreased absorption and bioavailability w/ Al- or Mg-containing antacids, or Fe or Zn preparations. Concomitant use of corticosteroids increases the risk of severe tendon disorders esp in elderly (>60 yr). Decreased absorption w/ sucralfate or didanosine.
Potentially Fatal: Concurrent use of class Ia (e.g. quinidine, procainamide) or III (e.g. amiodarone, sotalol) antiarrhythmic drugs or w/ other drugs that prolong QT interval (e.g. erythromycin, TCAs, antipsychotic agents) may cause additive effect on QT interval prolongation.
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