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Perion
Globe Pharmaceuticals Ltd.
Generic: Domperidone
Safety Advices
বাংলা
English
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Perion. Please consult your doctor.
CONSULT YOUR DOCTOR
Perion may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
SAFE IF PRESCRIBED
Perion is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.
UNSAFE
Perion may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
CAUTION
Perion should be used with caution in patients with kidney disease. Dose adjustment of Perion may be needed. Please consult your doctor.
CAUTION
Perion should be used with caution in patients with liver disease. Dose adjustment of Perion may be needed. Please consult your doctor.
Use of Perion is not recommended in patients with moderate and severe liver disease.
Medicine Overview of Perion 5mg/5ml Suspension
Introduction
Perion is a prescription medicine used in the treatment of indigestion, nausea and vomiting. It blocks the substance on the brain that triggers nausea or vomiting and it also increases the movement of food in the stomach, thereby improves digestion. Perion is taken before meals in a dose and duration as advised by the doctor. The dose you are given will depend on your condition and how you respond to the medicine. You should take this medicine until your doctor tells you to stop. Let your doctor know about all other medications you are taking as some may affect, or...
... Show moreUses of Perion
- Indigestion
- Nausea
- Vomiting
Side effects of Perion
Common
- Headache
- Dryness in mouth
- Stomach pain
- Diarrhea
How to use Perion
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Perion is to be taken empty stomach.
How Perion works
Perion is a prokinetic. It works on the region in the brain that controls vomiting. It also acts on the upper digestive tract to increase the movement of the stomach and intestines, allowing food to move more easily through the stomach.
What if you forget to take Perion?
If you miss a dose of Perion, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
- Perion helps relieve nausea, vomiting and indigestion.
- It should be taken before meals as per the dose and duration prescribed by your doctor.
- It may cause dizziness and sleepiness. Do not drive or do anything that requires mental focus until you know how it affects you.
- Avoid consuming alcohol when taking Perion as it may cause excessive drowsiness.
- Dry mouth may occur as a side effect. Frequent mouth rinses, good oral hygiene, increased water intake and sugarless candy may help.
- Inform your doctor if you get watery diarrhea, fever, or stomach pain that does not go away.
- Do not take it for longer than 7 days without consulting your doctor.
Brief Description
Indication
Gastritis, Lactation, Migraine, Nausea and vomiting, Gastroparesis, Non ulcer dyspepsia
Administration
Should be taken on an empty stomach. Take 15-30 min before meals.
Adult Dose
Oral
Adults:
Nausea and vomiting 10-20 mg 4-8 hrly. Max: 80 mg/day.
Non ulcer dyspepsia 10 mg 3-4 times daily. Max: 20 mg 3-4 times daily. Last dose to be taken at bedtime.
Migraine 20 mg 4 hrly. Max: 4 doses/24 hr.
Rectal:
Nausea and vomiting 60 mg twice daily.
Elderly: No dosage adjustment needed.
Hepatic impairment: No dosage adjustment needed.
Child Dose
Oral
Children : 0.2 - 0.4 mg/kg every 4 - 8 hours daily.
Rectal
Child: 15 kg: 30 mg bid;
>12 yr >35 kg: 60 mg bid.
Renal Dose
Renal impairment: Mild to moderate: No dosage adjustment needed. Severe: Reduce dosing to 1-2 times daily w/ prolonged treatment.
Contraindication
Hypersensitivity. GI haemorrhage, obstruction and perforation, patients with prolactin releasing pituitary hormone, chronic admin or routine prophylaxis of postoperative nausea and vomiting.
Mode of Action
Domperidone is a peripheral dopamine-receptor blocker. It increases oesophageal peristalsis, enhances gastroduodenal coordination and lowers oesophageal sphincter pressure, gastric motility and peristalsis, thus facilitating gastric emptying and decreasing small bowel transit time.
Precaution
Phaeochromocytoma; children<2 yr, elderly; renal or hepatic impairment. Risk of cardiac arrhythmias and hypokalaemia if administered IV. Pregnancy and lactation.
Side Effect
Drowsiness, extrapyramidal reactions, galactorrhoea, gynaecomastia; constipation or diarrhoea, lassitude, decreased libido, skin rash, itch.
Potentially Fatal: Convulsions, arrhythmias and cardiac arrest, dysrrhythmias in patients with CV disease or hypokalaemia, patients on cancer chemotherapy. Seizures; hypertensive crisis in patients with phaeochromocytoma.
Interaction
May antagonise the hypoprolactinaemic effect of bromocriptine. May antagonise the prokinetic effect w/ opioid analgesics and antimuscarinics.
Potentially Fatal: Potent CYP3A4 inhibitors (e.g. ketoconazole, erythromycin or ritonavir) may increase serum domperidone levels and subsequently increasing the risk of QT prolongation.
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