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Beriberi and Wernick's encephalopathy, neuritis associated with pregnancy and pellagra.
Administration
Should be taken with food.
Adult Dose
Treatment and prophylaxis of mild chronic thiamine deficiency
Adult: 10-25 mg daily in single or divided doses.
Thiamine deficiency
Adult: 1 tablet (100mg) daily, up to 300 mg daily.
Wernicke-Korsakoff syndrome
Adult: Initially, 100 mg by slow IV Inj over 10 min, then 50-100 mg/day IM or IV until the patient can take oral thiamine.
Child Dose
Thiamine deficiency
10-50 mg/day PO in divided doses
Beriberi
10-25 mg IV/IM qDay (if crtically ill) or 10-50 mg/dose PO qDay for at least 2 weeks, THEN
5-10 mg/day PO for 1 month
Contraindication
Hypersensitivity
Mode of Action
Thiamine, a water soluble vitamin, combines with ATP to form thiamine pyrophosphate, an essential coenzyme in carbohydrate metabolism.
Precaution
Parenteral admin. Increased daily requirements in pregnancy and lactation.
Side Effect
IV: Warm sensation, tingling, pruritus, pain, urticaria, weakness, sweating, nausea, restlessness, tightness of the throat, angioedema, respiratory distress, cyanosis, pulmonary oedema, GI bleeding, transient vasodilation and hypotension, vascular collapse.
IM: Tenderness and induration.
Potentially Fatal: Very rarely, fatal anaphylactic shock.
Interaction
May enhance the effect of neuromuscular blocking agents.
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