Introduction
Acliz PLUS is a combination medicine used in the treatment of vertigo and motion sickness. It prevents the feeling of nausea, vomiting, light-headedness and other symptoms of vertigo.
Acliz PLUS is taken with or without food in a dose and duration as advised by the doctor. The dose you are given will depend on your condition and how you respond to the medicine. You should keep taking this medicine for as long as your doctor recommends. If you stop treatment too early your symptoms may come back and your condition may worsen. Let your healthcare team know about all other medications you are taking as some may affect, or be affected by this medicine.
Common side effects of this medicine include dryness in the mouth, headache, and fatigue. These are usually mild and disappear after a short time. Consult your doctor if they persist. This medicine can also cause dizziness and drowsiness, so do not drive or do anything that requires mental focus until you know how this medicine affects you. Avoid drinking alcohol while taking this medicine as it can worsen your drowsiness.
Side effects of Acliz PLUS
Common
- Dryness in mouth
- Allergic reaction
- Drowsiness
- Headache
- Fatigue
How to use Acliz PLUS
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Acliz PLUS may be taken with or without food, but it is better to take it at a fixed time.
How Acliz PLUS works
Acliz PLUS is a combination of two medicines: Meclizine and vitamin B6 (pyridoxine) which treat nausea and vomiting associated with pregnancy. Meclizine is an antihistamine which works by blocking the action of a chemical messenger (histamine), thereby controlling nausea, vomiting, and dizziness. Pyridoxine (vitamin B6) is a form of vitamin B which possesses anti-nausea properties.
Indication
Nausea, vomiting, dizziness, motion sickness, radiation sickness and vertigo associated with diseases of vestibular motion sickness, radiation sickness and vertigo associated with diseases of vestibular system, morning sickness during pregnancy, drug induced nausea, vomiting induced by oral contraceptives or Estrogen preparations.
Administration
May be taken with or without food.
Adult Dose
Oral
Motion sickness
Adult: 25-50 mg Meclizine 1 hr before travelling and repeat 24 hrly if needed.
Vertigo and vestibular disorders
Adult: 25-100 mg Meclizine daily in divided doses. Discontinue if there is no response after 1-2 wk of treatment.
Radiation sickness:
50 mg Meclizine administered 2-12 hours prior to radiation treatment.
Pyridoxine (vitamin B6) has been shown to be safe and effective in dosages of 50 to 200 mg per day.
Child Dose
Oral
<12 years: Safety and efficacy not established
Contraindication
Meclizine Hydrochloride and Pyridoxine Hydrochloride is contraindicated in patients who are hypersensitive to these ingredients.
Mode of Action
Meclozine blocks vasopressor response to histamine and has a slight blocking action against acetylcholine. It decreases excitability of the middle ear labyrinth and blocks conduction in the middle ear vestibular-cerebellar pathways.
Pyridoxine is a water-soluble vitamin which functions in the metabolism of carbohydrates, proteins and fats. It is essential in Hb formation and GABA synthesis within the CNS. It also aids in the release of glycogen stored in the liver and muscles.
Precaution
Prostate hypertrophy, obstruction of bladder neck, narrow angle glaucoma, pyloric stenosis. May impair ability to drive or operate machinery. Pregnancy.
Lactation: Not known if excreted in milk; use caution
Side Effect
Drowsiness, thickening of bronchial secretions, dry mouth, fatigue, blurred vision.
Interaction
Additive effects with CNS depressants, neuroleptics, anticholinergics, alcohol.