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Chronic Disease Lab Promotion

Pulmoten 62.5

Tablet-(62.5mg)
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Unimed Unihealth Pharmaceuticals Ltd.

Generic: Bosentan

10 Tablets (1 Strip)
৳ 454.73
৳ 500
9% OFF

Medicine Overview of Pulmoten 62.5 62.5mg Tablet

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Introduction

Pulmoten 62.5 is a prescription medicine used to treat pulmonary arterial hypertension (high pressure in the blood vessels that carry blood from the heart to the lungs). It even helps to improve your quality of life, exercising ability and delay in disease progression. Pulmoten 62.5 should be taken with or without food. This medicine should be used regularly to get the most benefit from it. The dose and how often you take it depends on what you are taking it for. Your doctor will decide how much you need to improve your symptoms. You should take this medicine for as long as it is prescribed for you. The most common side effects of this medicine include headache, swelling of the legs and ankles, and diarrhea. If these bother you or appear serious, let your doctor know. There may be ways of reducing or preventing them. Some serious side effects which mean your doctor should know immediately include Anemia (low number of red blood cells) and abnormal liver function such as nausea, vomiting, dark urine, fever, and dark urine. Your doctor might check you for blood tests to check for anemia and liver function. Before taking this medicine, let your doctor know if you have liver dysfunctioning. Inform your doctor if you are pregnant or breastfeeding. Women are suggested to use reliable contraceptive pills to avoid pregnancy and should continue even after one month of stopping the treatment. Your doctor should also know about all other medicines you are taking as many of these may make this medicine less effective or change the way it works.

Uses of Pulmoten 62.5

  • Pulmonary arterial hypertension (PAH)

Side effects of Pulmoten 62.5

Common
  • Headache
  • Ankle swelling
  • Edema (swelling)
  • Diarrhea
  • Anemia (low number of red blood cells)
  • Respiratory tract infection

How to use Pulmoten 62.5

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Pulmoten 62.5 may be taken with or without food, but it is better to take it at a fixed time.

How Pulmoten 62.5 works

Pulmoten 62.5 is an endothelin receptor blocker. It blocks the action of endothelin (a natural substance) that causes blood vessels to narrow (constrict). This narrowing increases the pressure in the blood vessels of the lungs. Pulmoten 62.5 helps relax these blood vessels and increases the supply of blood to the lungs.

What if you forget to take Pulmoten 62.5?

If you miss a dose of Pulmoten 62.5, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Quick Tips

  • Your doctor has prescribed Pulmoten 62.5 to treat high pressure in the blood vessels that carry blood from the heart to the lungs (the pulmonary arteries).
  • It helps improve your quality of life, exercising ability, and delay disease progression.
  • Notify your doctor if you are pregnant or planning to conceive or breastfeeding.
  • Your doctor may ask you to get routine blood tests done to check for anemia and to assess the functioning of your liver.
  • Do not drive or do anything requiring concentration until you know how Pulmoten 62.5 affects you.
  • Females with reproductive potential should use a reliable form of birth control while using and 1 month after stopping Pulmoten 62.5 as it is toxic to an unborn baby.
  • Inform your doctor if you notice weight gain, swelling of your arms and legs, or difficulty breathing.
  • Inform your doctor if you notice yellowing of skin/eye, dark urine, or stomach pain.

Brief Description

Indication

Pulmonary Arterial Hypertension (PAH)

Administration

Bosentan should be administered in the morning and evening with or without food.

Adult Dose

Oral Pulmonary hypertension Adult: >12 yr <40 kg: Initial and maintenance dose is 62.5 mg bid; >40 kg: Initially, 62.5 mg bid for 4 wk, then increased to a maintenance dose of 125 mg bid. Elderly: No dosage adjustment needed. Hepatic impairment: Mild: No dosage adjustment needed. Moderate and severe: Contraindicated.

Renal Dose

Renal impairment: No dosage adjustment needed in renal impairment or dialysis patients.

Contraindication

Patients with WHO Class II symptoms showed reduction in the rate of clinical deterioration and a trend for improvement in walk distance. Physicians should consider whether these benefits are sufficient to offset the risk of hepatotoxicity in WHO Class II patients, which may preclude future use as their disease progresses.

Mode of Action

Competitive antagonist of endothelin-1; blocks endothelin receptors on vascular endothelium and smooth muscle resulting in inhibition of vasoconstriction

Precaution

Hepatotoxicity and teratogenicity. Elevations of AST or ALT associated with Bosentan are dose-dependent, occur both early and late in treatment, usually progress slowly, are typically asymptomatic, and usually have been reversible after treatment interruption or cessation. Aminotransferase elevations also may reverse spontaneously while continuing treatment with Tracleer. Liver aminotransferase levels must be measured prior to initiation of treatment and then monthly and therapy adjusted accordingly .Discontinue Bosentan if liver aminotransferase elevations are accompanied by clinical symptoms of hepatotoxicity (such as nausea, vomiting, fever, abdominal pain, jaundice, or unusual lethargy or fatigue) or increases in bilirubin > 2 Lactation: Not known if excreted in breast milk; not recommended

Side Effect

>10% Hgb decreased; >1 g/dL (57%),Inhibition of spermatogenesis (25%),Headache (16-22%),Nasopharyngitis (11%),Transaminses increased (12%),Respiratory tract infection (22%),Increased transaminases (12%) 1-10% Edema, lower limb (5-8%),Flushing (7-9%),Hypotension (7%),Hepatic abnormalities (4%),Palpitations (4%),Anemia (3%),Dyspepsia (4%),Edema, general (4%),Fatigue (2%),Pruritus (4%) <1% Hyperbilirubinemia,Vasculitis,Jaundice,Leukopenia,Thrombocytopenia,Leukocytoplastic

Pregnancy Category Note

Pregnancy Based on animal data, bosentan may cause fetal harm, including birth defects and fetal death, when administered to a pregnant female and is contraindicated during pregnancy; see Contraindications and Black Box Warnings In animal reproduction studies, oral administration of bosentan to pregnant rats at 2 times the maximum recommended human dose (MRHD) on a mg/m2 basis caused teratogenic effects in rats (eg, malformations of the head, mouth, face, and large blood vessels) Advise pregnant women of the potential risk to a fetus Patient should contact her physician immediately for pregnancy testing if onset of menses is delayed or pregnancy is suspected If the pregnancy test is positive, the physician and patient must discuss the risks to her, the pregnancy, and the fetus Based on findings in animals, bosentan may impair fertility in males of reproductive potential; It is unknown whether effects on fertility would be reversible Lactation There are no data on the presence of bosentan in human milk, the effects on the breastfed infant, or the effect on milk production Because of the potential for serious adverse reactions, such as fluid retention and hepatotoxicity, in breastfed infants from bosentan, advise women not to breastfeed during treatment with bosentan

Interaction

Increased bosentan levels w/ CYP3A4 inhibitors (e.g. ketoconazole, ritonavir, diltiazem), CYP2C9 inhibitors (e.g. amiodarone, fluconazole), tacrolimus. Rifampicin initially increases but subsequently decreases bosentan concentration. May decrease plasma levels of warfarin, statins (e.g. simvastatin, lovastatin), hormonal contraceptives, sildenafil, tadalafil. Potentially Fatal: Increased risk of hepatotoxicity may occur w/ glibenclamide. Ciclosporin markedly increases bosentan concentration.

Buy Pulmoten 62.5 from Arogga

In Bangladesh, you can get the original Pulmoten 62.5. Select your favorite one from a large collection of medicine products. Order from App to get more offers and better experience.

What is the price of Pulmoten 62.5 in Bangladesh?

The latest price of Pulmoten 62.5 in Bangladesh is 454.73৳. You can buy Pulmoten 62.5 at the best price from Arogga. Order online through our website or mobile app and get fast home delivery anywhere in Bangladesh. Cash on Delivery (COD) is available all over Bangladesh.

Frequently Questions & Answers

Is the product authentic?

Yes. Arogga sources all medicines and health products directly from trusted suppliers, distributors, or manufacturers. Every product is verified before delivery.

Does Arogga deliver all over Bangladesh?

Yes, Arogga delivers nationwide. You can order from anywhere in Bangladesh.

Is Cash on Delivery(COD) available?

Yes, Cash on Delivery is available across Bangladesh for most products.

How long does delivery take?

Delivery usually takes 24–48 hours inside Dhaka and 3–5 days outside Dhaka, depending on location and courier load.

Can I return or replace the product?

If the product is damaged, incorrect, or expired, you can request a replacement or refund according to Arogga’s return policy.

Safety Advices

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UNSAFE
Pulmoten 62.5 may cause excessive drowsiness with alcohol.
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UNSAFE
Pulmoten 62.5 is highly unsafe to use during pregnancy. Seek your doctor's advice as studies on pregnant women and animals have shown significant harmful effects to the developing baby.
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CONSULT YOUR DOCTOR
Pulmoten 62.5 is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
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UNSAFE
Pulmoten 62.5 may cause side effects which could affect your ability to drive. As Pulmoten 62.5 can induce hypotension (decrease of your blood pressure) which can make you feel dizzy and this can affect your ability to drive.
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SAFE IF PRESCRIBED
Pulmoten 62.5 is safe to use in patients with kidney disease. No dose adjustment of Pulmoten 62.5 is recommended.
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CAUTION
Pulmoten 62.5 should be used with caution in patients with liver disease. Dose adjustment of Pulmoten 62.5 may be needed. Please consult your doctor. Use of Pulmoten 62.5 is not recommended in patients with moderate and severe liver disease.

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Disclaimer

The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts.