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Combigan
Eskayef Pharmaceuticals Ltd.
Generic: Brimonidine Tartrate 0.2% + Timolol Maleate 0.5% Eye prep
Safety Advices
বাংলা
English
CONSULT YOUR DOCTOR
Combigan may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
SAFE IF PRESCRIBED
Combigan is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
To reduce the amount of Combigan that reaches the breastmilk, place pressure over the corner of the eye for 1 minute or more, then remove the excess solution with an absorbent tissue.
UNSAFE
Combigan may cause side effects which could affect your ability to drive.
Combigan may cause blurred or abnormal vision. This effect may seem worse at night or in reduced lighting and this may affect the ability to drive.
Medicine Overview of Combigan 0.2%+0.5% Eye Drop
Introduction
Combigan is a prescription that is used for the treatment of pressure in the eyes (ocular hypertension) and glaucoma. It works by decreasing the pressure of fluid in the eye (aqueous humor), which helps in lowering the increased eye pressure. Combigan is to be used only in the affected eye in the dose and duration as advised by the doctor. Wash your hands before using this medicine. It is advised to check the label for directions before use. Do not skip any doses and finish the full course of treatment even if you feel better. Stopping the medicine too early...
... Show moreUses of Combigan
- Ocular hypertension
- Glaucoma
Side effects of Combigan
Common
- Itching
- Stinging sensation
- Foreign body sensation
- Burning sensation in eye
- Eye redness
- Blurred vision
- Tiredness
- Drowsiness
- Headache
- Dryness in mouth
How to use Combigan
This medicine is for external use only. Take it in the dose and duration as advised by your doctor. Check the label for directions before use. Hold the dropper close to the eye without touching it. Gently squeeze the dropper and place the medicine inside the lower eyelid. Wipe off extra liquid.
How Combigan works
Combigan is a combination of two medicines: Timolol and Brimonidine. Timolol is a beta blocker while Brimonidine is a sympathomimetic. They work by decreasing the production of aqueous humor (fluid in the eye), thereby lowering the increased eye pressure.
Quick Tips
- Combigan is a combination of two medicines that lowers high pressure in the eye and reduces the risk of vision loss.
- Apply pressure on the corner of the eye (close to the nose) for about 1 minute, immediately after instilling the drop.
- If you wear soft contact lenses, remove them before putting in these eye drops and wait at least 15 minutes before putting your lenses back in.
- Do not touch the tip of the dropper to any surface, or to your eye, to avoid contaminating the eye drops.
- Wait for at least 5-10 minutes before delivering the next medication in the same eye to avoid dilution.
- It may cause short term blurring of vision when first used. Use caution before driving or using machines.
- It may cause temporary burning or itching sensation in the eye. Inform your doctor if this does not go away.
- Make sure to use within 4 weeks of opening the bottle.
Brief Description
Indication
Open-angle glaucoma, Ocular hypertension
Adult Dose
Adult: Ophth: Instill 1 drop 2 times/day approximately 12 hours apart.
Contraindication
Hypersensitivity. Patients receiving MAO inhibitor therapy.
Mode of Action
Brimonidine is an alpha 2-adrenoceptor agonist which works to reduce aqueous humor production and increase uveoscleral flow.
Timolol is a non-selective beta-adrenergic receptor blocker. It does not have significant intrinsic sympathomimetic activity, direct myocardial depressant activity or local anaesth activity. Exact mechanism of ocular hypotensive effect is unclear, but it is thought to be related to reduction of aqueous humour formation. beta-blockade also causes lowering of BP.
Precaution
Patients wearing soft contact lenses should wait for at least 15 min after instilling brimonidine tartrate before inserting soft contact lenses. Renal or hepatic impairment. CV disease. Use with caution in patients with depression, cerebral or coronary insufficiency, Raynaud's phenomenon, orthostatic hypotension or thromboangitis obliterans. Pregnancy, lactation.
Lactation: use caution
Side Effect
5-15%
Allergic conjunctivitis,Conjunctival folliculosis,Conjunctival hyperemia,Eye pruritus,Ocular burning,Stinging
1-5%
Asthenia,Blepharitis,Corneal erosion,Depression,Epiphora,Eye discharge,Eye dryness,Eye irritation,Eye pain,Eyelid edema,Eyelid erythema,Eyelid pruritus,Foreign body sensation,Headache,Hypertension,Oral dryness,Somnolence,Superficial punctate keratitis,Visual disturbance
Pregnancy Category Note
Pregnancy Category: C
Lactation: use caution
Interaction
Brimonidine Tartrate: Possibility of an additive or potentiating effect with CNS depressants e.g. alcohol, barbiturates, opiates, sedatives or anaesthetics. Caution when used with ?-blockers (ophthalmic and systemic), antihypertensives or cardiac glycosides. TCAs can affect the metabolism and uptake of circulating amines.
Timolol: Concomitant admin w/ reserpine may increase hypotension and bradycardia. Additive effects w/ other antihypertensives (e.g. hydralazine, methyldopa). Increased ?-adrenergic blockade (e.g. decreased heart rate) w/ quinidine. Rebound HTN due to abrupt withdrawal of clonidine. Hypotensive effect may be antagonised by NSAIDs (e.g. indomethacin, ibuprofen).
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