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Safety Advices
বাংলা
English
CAUTION
Caution is advised when consuming alcohol with Rizagrin. Please consult your doctor.
CONSULT YOUR DOCTOR
Rizagrin may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
SAFE IF PRESCRIBED
Rizagrin is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
UNSAFE
Rizagrin may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
CAUTION
Rizagrin should be used with caution in patients with severe kidney disease. Dose adjustment of Rizagrin may be needed. Please consult your doctor.
Use of Rizagrin is not recommended in patients with severe kidney disease.
CAUTION
Rizagrin should be used with caution in patients with liver disease. Dose adjustment of Rizagrin may be needed. Please consult your doctor.
Medicine Overview of Rizagrin 5mg Tablet
Introduction
Rizagrin is a prescription medicine used in the treatment of acute attack of migraine. It relieves the symptoms of migraine and prevents the attack from becoming worse. This medicine helps by narrowing the blood vessels, thereby relieving migraine headaches. Rizagrin may be taken with or without food. However, it is advised to take it at the same time each day as this helps to maintain a consistent level of medicine in the body. Do not skip any doses and finish the full course of treatment even if you feel better and if you have missed a dose, take it as...
... Show moreUses of Rizagrin
- Acute migraine headache
Side effects of Rizagrin
Common
- Dizziness
- Dryness in mouth
- Heaviness
- Jaw pain
- Nausea
- Neck pain
- Sleepiness
- Throat pain
- Weakness
How to use Rizagrin
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Rizagrin may be taken with or without food, but it is better to take it at a fixed time.
How Rizagrin works
Migraine headaches are thought to result from the dilatation of blood vessels in the head. Rizagrin works by constricting (narrowing) these blood vessels, thereby relieving the migraine headaches.
Quick Tips
- You have been prescribed Rizagrin for treatment of migraine headaches.
- Some tips that may help avoid a migraine attack:
- It may cause sleepiness. Don't drive or do anything that requires mental focus until you know how it affects you.
- Notify your doctor if your migraine occurs more often after starting the medication.
- Notify your doctor if you have stomach pain, headache, bloody diarrhoea or worsening high blood pressure.
- Inform your doctor if you have a history of heart disease or stroke.
- This medication does not prevent migraine attacks from happening.
Brief Description
Indication
Acute migraine attacks
Administration
May be taken with or without food.
Adult Dose
Oral Acute migraine attacks Adult: Initially, 10 mg. If ineffective, 2nd dose should not be taken for the same attack. If symptoms recur after initial response, a further dose of 10 mg may be given. Doses should be separated by at least 2 hr. Max: 20 mg/24 hr. If patient is also taking propanolol, initiate with 5 mg. Max: 10 mg/24 hr. Ensure that the 2 drugs are separated by at least 2 hr. Hepatic Impairment For mild-moderate impairment, initate with 5 mg. Further dose of 5 mg may be taken after an interval of at least 2 hr. Max:...
... Show moreChild Dose
Migraine Headache
Acute treatment of migraine with or without aura
40 kg) taking propranolol: Limit dose to 5 mg PO once q24hr as necessary; not to exceed 5 mg/24hr
Renal Dose
Renal Impairment
For mild-moderate impairment, initate with 5 mg. Further dose of 5 mg may be taken after an interval of at least 2 hr. Max: 10 mg/24 hr. Avoid in severe impairment.
Contraindication
History of MI, peripheral vascular disease, transient ishaemic attack, ischaemic heart disease or Prinzmetal's angina; uncontrolled hypertension; basilar or hemiplegic migraine; severe hepatic or renal impairment. Adolescent <18 yr.
Mode of Action
Rizatriptan is a selective serotonin (5-HT1) agonist in cranial arteries responsible for vasoconstriction and reduction of inflammation associated with antidromic neuronal transmission.
Precaution
Elderly; mild to moderate hepatic or renal impairment; coronary artery disease; pregnancy, lactation. May cause drowsiness. History of seizures. Ensure an interval of at least 24 hr after stopping an ergotamine compound and starting a serotonin (5-HT1) agonist.
Lactation: Unknown; use with caution in breastfeeding
Side Effect
>10%
Drowsiness (13-30%, dose related),Fatigue (13-30%, dose related),Dizziness (11-15%)
1-10%
Dizziness (4-9%),Somnolence (4-8%),Fatigue (4-7%; dose related),Nausea (4-6%),Asthenia (1-5%),Hot flashes (1-5%),Paresthesia (3-4%),Dry mouth (3%),Chest pain (2-3%),Pain/pressure in chest, neck, throat, jaw (1%),Hypoesthesia (>1%),Palpations (>1%),Skin flushing (>1%)
<1%
Tachycardia,Angioedema,Wheezing,Hypertensive crisis,Bradycardia,Hallucination,Epidermal necrolysis,Hearing impairment,Arrhythmias,Myocardial infarction and coronary artery vasospasm in patients with CAD risk factors
Potentially Fatal: Toxic epidermal necrolysis.
Interaction
Increased serum concentrations with propranolol. Increased risk of vasospastic reactions when used with ergotamine and methysergide. Concurrent use with SSRIs may increase risk of serotonin syndrome.
Potentially Fatal: Concurrent use with or within 2 wk of stopping MAOI treatment.
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