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Safety Advices
বাংলা
English
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Ivaprex 5. Please consult your doctor.
CONSULT YOUR DOCTOR
Ivaprex 5 is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
CONSULT YOUR DOCTOR
Information regarding the use of Ivaprex 5 during breastfeeding is not available. Please consult your doctor.
UNSAFE
Ivaprex 5 may cause side effects which could affect your ability to drive.
Ivaprex 5 may cause transient luminous phenomena consisting mainly of phosphenes. The possible occurrence of such luminous phenomena should be taken into account especially when driving at night.
CAUTION
Ivaprex 5 should be used with caution in patients with severe kidney disease. Dose adjustment of Ivaprex 5 may be needed. Please consult your doctor.
Limited information is available for use of Ivaprex 5 in patients with severe kidney disease.
CAUTION
Ivaprex 5 should be used with caution in patients with liver disease. Dose adjustment of Ivaprex 5 may be needed. Please consult your doctor.
Use of Ivaprex 5 is not recommended in patients with severe liver disease.
Medicine Overview of Ivaprex 5mg Tablet
Introduction
Ivaprex 5 is a medicine used for treatment of angina (heart-related chest pain) and chronic (long-term) heart failure. It makes the heart work more efficiently by lowering the heart rate. This relieves chest pain and decreases the risk of hospitalization in heart failure patients. The dose will depend on what you are being treated for. Since the treatment for angina or heart failure is usually life-long, you should not stop using it without talking to your doctor. It should be taken with food at the same time each day. If you take too much in one go, your heart could...
... Show moreUses of Ivaprex 5
- Angina (heart-related chest pain)
- Heart failure
Side effects of Ivaprex 5
Common
- Slow heart rate
- Headache
- Luminous phenomena (Enhanced brightness)
- High blood pressure
How to use Ivaprex 5
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Ivaprex 5 is to be taken with food.
How Ivaprex 5 works
Ivaprex 5 is a heart rate lowering medication. It works by reducing the heart rate which lowers the oxygen requirement of the heart. As a result, the heart works more efficiently.
What if you forget to take Ivaprex 5?
If you miss a dose of Ivaprex 5, skip it and continue with your normal schedule. Do not double the dose.
Quick Tips
- Ivaprex 5 may cause dizziness or sleepiness. Do not drive or do anything requiring concentration until you know how it affects you.
- You may experience temporary changes in your vision such as enhanced visual brightness. These changes may occur within the initial 2 months of treatment and should gradually go away.
- Monitor your blood pressure when taking Ivaprex 5 as it can increase your blood pressure.
- Monitor your heart rate when taking this medicine, as low heart rate is a common side effect. Inform your doctor if you experience symptoms of low heart rate such as dizziness, tiredness and low energy.
Brief Description
Indication
Chronic stable angina, Heart Failure
Administration
Should be taken with food. Avoid excessive consumption of grapefruit juice.
Adult Dose
Oral Heart Failure Initial: 5 mg PO BID with meals (all see Dosage Modifications) After 2 weeks, assess patient and adjust dose to achieve a resting heart rate of 50-60 bpm (see dose adjustment section below) Thereafter, adjust dose prn based on resting heart rate and tolerability; not to exceed 7.5 mg BID Dose adjustment HR >60 bpm: Increase dose by 2.5 mg (given twice daily) up to a maximum dose of 7.5 mg BID HR 50-60 bpm: Maintain dose HR 75 yr Initiate treatment at 2.5 mg bid. Titrate up if necessary. Hepatic impairment Mild or moderate (Child-Pugh A...
... Show moreChild Dose
Safety and efficacy not established
Renal Dose
Renal impairment:
CrCl (ml/min) Dosage Recommendation
<15 Use w/ caution.
Contraindication
Pregnancy, lactation, resting heart rate <60 beats/min prior to treatment, cardiogenic shock, acute myocardial infarction, severe hypotension (<90/50 mmHg), severe hepatic insufficiency, sick sinus syndrome, sino-atrial block, heart failure patients with NYHA class III-IV, pacemaker dependent, unstable angina, 3rd degree AV-block, concurrent use with potent CYP3A4 inhibitors.
Mode of Action
Ivabradine is a heart rate lowering agent that works through selective and specific inhibition of the cardiac pacemaker If current. If current controls the spontaneous diastolic depolarisation in the sinus node and regulate heart rate.
Precaution
Reduce dose if resting heart rate is persistently <50 beats/min or patient develops bradycardia symptoms during treatment; discontinue if heart rate <50 beats/min and symptoms persist. Not recommended in patient with AF or other cardiac arrhythmias that interfere with sinus node rhythm; monitor regularly for AF occurrence. Not recommended for concomitant use with heart rate reducing calcium channel blockers (e.g. diltiazem or verapamil), immediate use after a stroke or in patients with 2nd degree AV-block. Severe renal insufficiency, Moderate hepatic insufficiency. Stop treatment if visual field deteriorates unexpectedly. Patients with retinitis pigmentosa.
Side Effect
1-10%
Bradycardia (10%)
Hypertension or increased blood pressure (8.9%)
Atrial fibrillation (8.3%)
Luminous phenomena (phosphenes) or visual brightness (2.8%)
Interaction
Concomitant use with QT-prolonging drugs (e.g. quinidine, disopyramide, bepridil, sotalol, ibutilide, amiodarone, pimozide, ziprasidone, sertinole, mefloquine, halofantrine, pentamide, cisapride, erythromycin IV) is not recommended as QT prolongation may be enhanced by heart rate reduction. Concentrations may increase when used with CYP3A4 inhibitors. Use with verapamil or diltiazem (moderate CYP3A4 inhibitors) is not recommended. If used with other moderate CYP3A4 inhibitors (e.g. fluconazole), may consider starting at lower dose and with heart rate monitoring if resting heart rate >60 beats/min. Concentration may be reduced with CYP3A4 inducers (e.g. rifampicin, barbiturates, phenytoin, St John's Wort) and may require Ivabradine dose adjustment. Potentially...
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