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Defiron
Square Pharmaceuticals PLC.
Generic: Elemental Iron (Iron iii Hydroxide Sucrose Complex)
Safety Advices
বাংলা
English
UNSAFE
It is unsafe to consume alcohol with Defiron.
SAFE IF PRESCRIBED
Defiron is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
SAFE IF PRESCRIBED
Defiron is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.
CONSULT YOUR DOCTOR
It is not known whether Defiron alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react.
CAUTION
Defiron should be used with caution in patients with kidney disease. Dose adjustment of Defiron may be needed. Please consult your doctor.
CAUTION
Defiron should be used with caution in patients with liver disease. Dose adjustment of Defiron may be needed. Please consult your doctor.
Medicine Overview of Defiron 100mg/5ml Injection
Introduction
Defiron is an iron replacement product. It is used to treat a type of anemia where you have too few red blood cells because you have too little iron in your body (iron-deficiency anaemia). Iron is needed to produce the red blood cells that carry oxygen around your body. Defiron is given as injection by your doctor or nurse. You will be watched carefully to make sure you do not have an allergic reaction. Your doctor will decide how much dose you need depending on the cause of your anaemia, it may help to eat a well-balanced diet that has...
... Show moreUses of Defiron
- Iron deficiency anemia
- Anemia due to chronic kidney disease
Side effects of Defiron
Common
- Injection site reactions (pain, swelling, redness)
- Nausea
- Dark colored stool
How to use Defiron
Your doctor or nurse will give you this medicine. Kindly do not self administer.
How Defiron works
Defiron is an anti-anemic medication. It replenishes the iron stores in your body. Iron is vital for the formation of new red blood cells and hemoglobin, a substance that gives these cells the ability to transport oxygen.
What if you forget to take Defiron?
If you miss a dose of Defiron, please consult your doctor.
Quick Tips
- Defiron is given as a slow injection or infusion under the supervision of a doctor.
- Take it as per dose and duration suggested by the doctor.
- Avoid drinking alcohol while taking this medicine as it may worsen the side effects.
- You may be asked for regular blood tests to check for blood cells and iron levels in the body.
- It might cause lowering of blood pressure. Continuous monitoring of blood pressure is required while taking this medicine.
- Inform your doctor if you are pregnant, planning pregnancy or breastfeeding.
Brief Description
Indication
Iron deficiency anemia, in pregnancy and in non-dialysis dependent chronic kidney disease (CKD) patients, hemodialysis dependent CKD patients or peritoneal dialysis CKD patients
Administration
Before administering a slow intravenous injection, a test dose of 1 ml (20 mg of iron) should be injected slowly over a period of 1 to 2 minutes. If no adverse events occur within 15 minutes of completing the test dose, then the remaining portion of the injection may be given. As injection: Iron Sucrose can also be administered undiluted by slow IV injection at a rate of 1 ml Iron Sucrose (20 mg Iron) in at least 1 minute a maximum of 10 ml Iron Sucrose (200 mg Iron) can be administered per injection in at least 10 minutes....
... Show moreAdult Dose
Adults and the Elderly:
Iron-deficiency Anemia in Chronic Kidney Disease
Hemodialysis-dependent CKD: 100 mg elemental iron IV (injection or infusion over 2-5 min) per dialysis session not to exceed total cumulative dose of 1000 mg divided in 3 doses/week
Non-dialysis-dependent CKD: 200 mg IV injection for 5 doses in over 14 days (cumulative 1000 mg in 14-day period)
Peritoneal dialysis-dependent CKD: 300 mg IV infusion (1.5 hr) for 2 doses 14 days apart, THEN 400 mg IV infusion (2.5 hr) 14 days later (cumulative 1000 mg divided in 3 doses/week)
Child Dose
Iron-deficiency Anemia in Chronic Kidney Disease
Indicated for maintenance treatment of iron-deficient anemia associated with chronic kidney disease
<2 years: Safety and efficacy not established
Hemodialysis-dependent: 0.5 mg/kg IV q2weeks for 12 weeks; not to exceed 100 mg/dose
Non-dialysis dependent or peritoneal-dependent (on erythropoietin): 0.5 mg/kg IV q4weeks for 12 weeks; not to exceed 100 mg/dose
Contraindication
The use of Iron Sucrose is contraindicated in patients with evidence of Iron overload e.g. Haemochromatosis, thalassemia or haemosiderosis and in patients with known hypersensitivity to Iron preparations or any components preparation, in patients with anemia not caused by Iron deficiency.
Mode of Action
Iron: Essential component in the formation of hemoglobin; adequate amounts of iron are necessary for effective erythropoiesis; also serves as a cofactor of several essential enzymes, including cytochromes that are involved in electron transport. Replacement of iron stores found in hemoglobin, myoglobin, and enzymes; works to transport oxygen via hemoglobin.
Precaution
Iron Sucrose should be administered with caution in patients with asthma, eczema, other atopic allergies or allergic reaction to other parenteral Iron preparations, low binding capacity and/or folic acid deficiency, liver dysfunction, acute or chronic infection. Baseline tests: Ensure Hgb, Hct, serum ferritin and transferrin saturation is determined before starting therapy and periodically during treatment. Note that serum Iron levels may be reliably obtained 48 hours after IV dosing. Blood Pressure: Monitor Blood Pressure during infusion. If hypotension occurs, slow the rate of infusion. If hypotension continues, discontinue infusion and be prepared to treat appropriately. Discontinue oral Iron preparations before...
... Show moreSide Effect
>10%
Hypotension (36%),Muscle cramps (23%),Headache,Nausea
1-10%
Dizziness,Fatigue,Arthralgia,Back pain,Hypertension,Fluid overload,Peripheral edema,Cough,Vomiting,Diarrhea,Constipation,Pruritus
Frequency Not Defined
Potentially fatal anaphylaxis (rare)
Pregnancy Category Note
Pregnancy Published studies on intravenous iron sucrose treatment after first trimester of pregnancy not shown adverse maternal or fetal outcomes; available reports of intravenous iron sucrose use in pregnant women during first trimester are insufficient to assess risk of major birth defects and miscarriage; iron deficiency anemia during pregnancy should be treated because there are risks to mother and fetus associated with untreated iron deficiency anemia (IDA) in pregnancy Animal data Animal reproduction studies of iron sucrose administered to rats and rabbits during period of organogenesis at elemental iron doses equivalent to maximum recommended human dose based on body surface...
... Show moreInteraction
May reduce the serum levels of cefdinir; stools may appear red due to the formation of an insoluble iron-cefdinir complex. May reduce the serum levels of eltrombopag. May decrease absorption of phosphate supplements. Concurrent use with trientine may result in reduction of serum levels of iron sucrose and/or trientine.
Potentially Fatal: Dimercaprol may increase the nephrotoxic effect of iron salts when used concurrently.
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