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Pethidine-R
Renata Limited
Generic: Pethidine Hydrochloride
Safety Advices
বাংলা
English
CAUTION
Caution is advised when consuming alcohol with Pethidine-R. Please consult your doctor.
CONSULT YOUR DOCTOR
Pethidine-R may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
SAFE IF PRESCRIBED
Pethidine-R is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
UNSAFE
Pethidine-R may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
CAUTION
Pethidine-R should be used with caution in patients with kidney disease. Dose adjustment of Pethidine-R may be needed. Please consult your doctor.
CAUTION
Pethidine-R should be used with caution in patients with liver disease. Dose adjustment of Pethidine-R may be needed. Please consult your doctor.
Medicine Overview of Pethidine-R 100mg/2ml Injection
Introduction
Pethidine-R is a pain relieving medicine. It is used to manage persistent, moderate to severe chronic pain that requires continuous, around-the-clock treatment for an extended period of time. Pethidine-R is generally administered by a healthcare professional. You should not self-administer this medicine at home. The dose and duration will depend on what you are taking it for and how well it helps your symptoms. The most common side effects of this medicine include injection site reactions (such as pain, redness, and swelling), headache, drowsiness, fatigue, vomiting, constipation, dry mouth, and sweating. If any of these side effects persist or get...
... Show moreUses of Pethidine-R
- Moderate to severe pain
Side effects of Pethidine-R
Common
- Sleepiness
- Vomiting
- Headache
- Dizziness
- Nausea
- Constipation
How to use Pethidine-R
Your doctor or nurse will give you this medicine. Kindly do not self administer.
How Pethidine-R works
Pethidine-R is an opioid analgesic (pain reliever) which works by blocking transmission of pain signals to the brain to lower pain perception.
What if you forget to take Pethidine-R?
If you miss a dose of Pethidine-R, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
- Use Pethidine-R as instructed by your doctor. Never take in greater amounts or more often than prescribed.
- It causes sleepiness or drowsiness. If this happens to you, do not drive or use machinery.
- Avoid consuming alcohol when taking the Pethidine-R, as it may cause excessive sleepiness or drowsiness.
- Inform your doctor if you have ever been diagnosed with kidney or liver problems.
- Store opioid pain relievers in a safe place and out of reach of others.
Brief Description
Indication
Anaesthesia, Postoperative pain, Moderate to severe acute pain, Obstetric analgesia
Administration
Reconstitution: Dilute with water for inj to a concentration of 5-10 mg/ml.
Adult Dose
Parenteral
Moderate to severe acute pain
Adult: 25-100 mg IM/SC inj or 25-50 mg by slow IV inj repeated after 4 hr.
Obstetric analgesia
Adult: 50-100 mg by IM/SC inj as soon as contractions occur at regular intervals; repeat after 1-3 hr if needed.
Max: 400 mg in 24 hr.
As a preoperative medication
Adult: 25-100 mg IM/SC given 1 hr before surgery.
Postoperative pain
Adult: 25-100 mg IM/SC inj every 2-3 hr if necessary.
Intravenous
Adjunct to anaesthesia
Adult: 10-25 mg by slow IV inj.
Hepatic impairment: Dose reductions may be necessary.
Child Dose
Parenteral Moderate to severe acute pain Child: SC/IM: 2 mth to 12 yr: 0.5-2 mg/kg; 12-18 yr: 20-100 mg. Repeat dose every 4-6 hr if needed. IV inj: Neonates and children >12 yr: 0.5-1 mg/kg IV inj every 10-12 hr if needed in those up to 2 mth and every 4-6 hr if needed in older children. 12-18 yr: 25-50 mg every 4-6 hr if needed. Alternatively, >1 mth: Loading dose: 1 mg/kg by IV inj followed by 100-400 mcg/kg/hr via continuous IV infusion adjusted according to response. As a preoperative medication Child: 1-2 mg/kg given IM 1 hr before...
... Show moreRenal Dose
Renal impairment: Dose reductions may be necessary.
Contraindication
Hypersensitivity.
Mode of Action
Pethidine is a phenylpiperidine derivative opioid analgesic. It acts mainly as mu-receptor agonist. Like most, opioid analgesics, it mimics endogenous opioids by activating opioid receptors in the central and peripheral nervous system. It reduces the release of neurotransmitter substances and also reduces the activity of postsynaptic neurons in the spinal cord thus preventing transmission of pain impulse.
Precaution
May impair ability to drive or operate machinery. Hypovolaemia, CV disease; adrenal insufficiency; biliary tract disorder; CNS depression or coma; history of drug abuse or acute alcoholism; head injury, intracranial lesions, elevated intracranial pressure; hepatic or renal impairment; morbidly obese; prostatic hyperplasia; toxic psychoses; pre-existing respiratory compromise (hypoxia and/or hypercapnia), COPD or other obstructive airway disease; sickle-cell disease; supraventricular tachycardia; thyroid dysfunction. Elderly and debilitated patients. Withdraw gradually. Pregnancy (avoid prolonged use or high doses at term) and lactation.
Side Effect
Hypotension; fatigue, drowsiness, dizziness, nervousness, headache, restlessness, malaise, confusion, depression, hallucinations, tremors, muscle twitches, increased intracranial pressure, seizure, serotonin syndrome; rash, urticaria; nausea, vomiting, constipation, anorexia, stomach cramps, xerostomia, biliary spasm, paralytic ileus, sphincter of Oddi spasm; ureteral spasms, decreased urination; pain at inj site; weakness; dyspnoea; histamine release, physical and psychological dependence.
Pregnancy Category Note
Pregnancy Category B, D if prolonged use/high doses at term.
Interaction
Increased pethidine metabolite levels with aciclovir, cimetidine, ritonavir. Reduced analgesic effects with phenytoin, barbiturates. Additive sedative and/or respiratory depressive effects with alcohol, barbiturates, benzodiazepines, phenothiazines, TCAs, other CNS depressants.
Potentially Fatal: Increased risk of serotonin syndrome with MAOIs (not be given concurrently or within 14 days of their discontinuation), serotonin agonists, serotonin reuptake inhibitors, sibutramine, TCAs.
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