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Cophilex
Opsonin Pharma Limited
Generic: Guaiphenesin + Pseudoephedrine Hydrochloride + Triprolidine Hydrochloride
Medicine Overview of Cophilex (30mg+100mg+1.25mg)/5ml Syrup
বাংলা
English
Indication
Pneumonia, Productive cough, Allergic rhinitis, Sneezing, Respiratory tract disorders, Cough & runny nose, Nasal congestion
Adult Dose
Adult: 10 ml (2 teaspoonful) three times a day.
Child Dose
Children over 12 years: 10 ml (2 teaspoonful) three times a day.
Children 6-12 years: 5 ml (1 teaspoonful) three times a day.
Children 2-5 years: 2.5 ml (1/2 teaspoonful) three times a day.
Contraindication
Patients with a known hypersensitivity to guaiphenesin, psedoephedrine or triprolidine. Contraindicated in persons under treatment with monoamine oxidase inhibitors within 2 weeks of stopping such treatment.
Patients with severe hypertension or severe coronary artery disease
Mode of Action
Triprolidine hydrochloride is a potent competitive histamine H1-receptor antagonist with antimuscarinic and mild sedative properties.
Pseudoephedrine is both an alpha-and beta-adrenergic receptor agonist. It causes vasoconstriction via direct stimulation of alpha-adrenergic receptors of the respiratory mucosa. It also directly stimulates beta-adrenergic receptors causing bronchial relaxation, increased heart rate and contractility.
Guaifenesin increases the volume and reduce the viscosity of tenacious sputum and is used as an expectorant for productive cough.
Precaution
It may cause drowsiness and impair performance in tests of auditory vigilance. It may also impair the patients ability to drive and also to use machineries. So, driving and operation of machineries should be avoided during treatment with Aquaphen. Although there are no objective data, Avoid the concomitant use of alcohol or other centrally acting sedatives. Although Pseudoephedrine has virtually no pressor effect in patients with normal blood pressure, Aquaphen should be used with caution in patients taking antihypertensive agents, tricyclic antidepressants or other sympathomimetic agents such as decongestant, appetite suppressants and amphetamine-like psychostimulants. It effects on the blood...
... Show moreSide Effect
Central nervous system (CNS) depression or excitation may occur. Sleep disturbance and rarely hallucination have been reported. Skin rashes, tachycardia, dryness of mouth, nose and throat have occasionally been reported. Urinary retention has been reported occasionally in men receiving pseudoephedrine; prostatic enlargement could have been an important predisposing factor.
Interaction
Sympathomimetics eg decongestants, TCAs, appetite suppressants, amphetamine-like psychostimulants; may increase BP w/ MAOIs. Bretylium, bethanidine, guanethidine, debrisoquine, methyldopa, alpha- & beta-adrenergic blocker; furazolidone, alcohol, sedatives.
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