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Safety Advices
বাংলা
English
UNSAFE
It is unsafe to consume alcohol with Diaplus XR.
CONSULT YOUR DOCTOR
Diaplus XR may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
SAFE IF PRESCRIBED
Diaplus XR is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
Monitoring of the breastfed infant's blood glucose is advisable during maternal therapy with Diaplus XR
CAUTION
Your ability to drive may be affected if your blood sugar is too low or too high. Do not drive if these symptoms occur.
CAUTION
Diaplus XR should be used with caution in patients with severe kidney disease. Dose adjustment of Diaplus XR may be needed. Please consult your doctor.
These patients can experience very low blood sugar levels with this medicine, which may take a long time to come back to normal
CAUTION
Diaplus XR should be used with caution in patients with severe liver disease. Dose adjustment of Diaplus XR may be needed. Please consult your doctor.
Medicine Overview of Diaplus XR 5mg Tablet
Introduction
Diaplus XR is a medicine used to treat type 2 diabetes mellitus in adults. It belongs to a group of medicines called sulfonylureas and helps control blood sugar levels in people with diabetes. This helps to prevent serious complications of diabetes like kidney damage and blindness. Diaplus XR may be used by itself or along with other medicines. It should be taken on an empty stomach. Take it regularly at the same time each day to get the most benefit. Your doctor will decide what dose is best for you and this may change from time to time according to...
... Show moreUses of Diaplus XR
- Type 2 diabetes mellitus
Side effects of Diaplus XR
Common
- Dizziness
- Diarrhea
- Nervousness
- Tremor
- Hypoglycemia (low blood glucose level)
- Flatulence
How to use Diaplus XR
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Diaplus XR is to be taken empty stomach.
How Diaplus XR works
Diaplus XR is an antidiabetic medication. It works by increasing the amount of insulin released by the pancreas in order to lower blood glucose.
What if you forget to take Diaplus XR?
You should skip a dose of Diaplus XR if a meal is skipped, and add a dose of medicine if you eat an extra meal.
Quick Tips
- Take it shortly before or with the first main meal of the day (usually breakfast). Avoid skipping meals.
- Be careful while driving or operating machinery until you know how Diaplus XR affects you.
- It can cause hypoglycemia (low blood sugar level) when used with other antidiabetic medicines, alcohol or if you delay or miss a meal.
- Always carry some sugary food or fruit juice with you in case you experience hypoglycemic symptoms such as cold sweats, cool pale skin, tremor and anxiety.
- Your doctor may check your liver function regularly. Inform your doctor if you develop symptoms, such as abdominal pain, loss of appetite, or yellowing of the eyes or skin (jaundice).
Brief Description
Indication
Type 2 DM
Administration
Immediate-release: Should be taken on an empty stomach. Take ½ hr before meals.
Extended-release: Should be taken with food. Swallow whole, do not chew/crush/divide.
Adult Dose
Oral Type 2 diabetes mellitus Adult: Initially, 2.5-5 mg daily as a single dose. Adjust at intervals of several days in increments of 2.5-5 mg daily. Doses >15 mg may be given in 2 divided doses. Max: 40 mg daily. Extended-release tablets Initial: 5 mg/day PO given with breakfast; dose adjustment based on blood glucose should not be done more frequently than every 7 days Maintenance range: 5-10 mg PO qDay; not to exceed 20 mg/day Elderly: 2.5 mg PO qDay initially; increase by 2.5-5 mg/day every 1-2 weeks as determined by blood glucose response at intervals of several days...
... Show moreChild Dose
Safety and efficacy not established
Renal Dose
Renal impairment: Not studied; if GFR <50 mL/min, may decrease dose by 50%
Severe: Contraindicated.
Contraindication
Hypersensitivity. Type 1 DM; ketoacidosis; severe renal or hepatic insufficiency. Pregnancy, lactation.
Mode of Action
Glipizide stimulates insulin release from pancreatic ?-cells and reduces glucose output from the liver. It also increases insulin sensitivity at peripheral target sites.
Precaution
Hypoglycaemia, stress, elderly. Thyroid impairment; moderate hepatic or renal impairment. Monitor blood glucose concentration.
Lactation: Not known if crosses into breast milk; not recommended
Side Effect
GI upsets, diarrhoea, nausea; allergic skin reactions, leucopenia, thrombocytopenia, agranulocytosis, hyponatraemia; jaundice; haemolytic anaemia, pancytopenia.
Potentially Fatal: Hypoglycaemia in presence of renal or hepatic damage and alcohol.
Interaction
Increased plasma concentration w/ certain antifungals (e.g. miconazole, fluconazole). Protein-bound drugs (e.g. NSAIDs, other sulfonamides, oral anticoagulants, hydantoins), probenecid, MAOIs, and chloramphenicol may potentiate hypoglycaemic action of glipizide. Diminished therapeutic effect w/ thiazides, other diuretics, phenothiazines, thyroid agents, oestrogens, OC, phenytoin, nicotinic acid, sympathomimetics, Ca channel blockers, rifampicin and isoniazid. Concomitant use w/ beta-blockers may impair glucose tolerance, increase frequency or severity of hypoglycaemia and block hypoglycaemia-induced tachycardia. Decreased serum concentration w/ colesevelam.
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