12-24 Hours
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Safety Advices
বাংলা
English
CAUTION
Caution is advised when consuming alcohol with Barif 40. Please consult your doctor.
CONSULT YOUR DOCTOR
Barif 40 may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
CONSULT YOUR DOCTOR
Barif 40 is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
UNSAFE
Barif 40 may cause side effects which could affect your ability to drive.
Barif 40 may cause dizziness, sleepiness, blurred vision, numbness or tingling sensation. This may affect your driving ability.
CAUTION
Barif 40 should be used with caution in patients with severe kidney disease. Dose adjustment of Barif 40 may be needed. Please consult your doctor.
Limited information is available regarding the use of Barif 40 in these patients.
CAUTION
Barif 40 should be used with caution in patients with severe liver disease. Dose adjustment of Barif 40 may be needed. Please consult your doctor.
Limited information is available regarding the use of Barif 40 in these patients.
Medicine Overview of Barif 40mg Tablet
Introduction
Barif 40 is a medicine used to treat and prevent gout. Gout happens when there is too much uric acid in your body and it forms into crystals which can appear around your joints leading to painful and swollen joints. This medicine helps to keep uric acid levels low. Barif 40 can be taken with or without food. You should keep taking it as recommended by your doctor even when you are not having a gout attack. If you stop, your symptoms may get worse because of the formation of more crystals in your joints. You can help yourself by...
... Show moreUses of Barif 40
- Gout
Side effects of Barif 40
Common
- Diarrhea
- Headache
- Increased liver enzymes
- Nausea
- Skin rash
- Gout flares
How to use Barif 40
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Barif 40 may be taken with or without food, but it is better to take it at a fixed time.
How Barif 40 works
Barif 40 is a xanthine oxidase inhibitor. It works by decreasing blood uric acid, which is the chemical that causes gout.
What if you forget to take Barif 40?
If you miss a dose of Barif 40, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
- Your doctor has prescribed Barif 40 to reduce episodes of gout attack.
- Take it at the same time every day, with or without food.
- Take plenty of fluids (2-3 litres) daily while on Barif 40.
- When you first start taking this medicine, you might have more gout attacks. Do not stop Barif 40 on having an acute attack of gout as that could make an attack worse.
- Do not consume alcohol while taking this medicine as it may cause your gout to flare up.
- Stop taking this medicine and inform your doctor straight away if you have symptoms like rash, itchiness, difficulties in breathing, fever or swelling of limbs or face.
Brief Description
Indication
Gout, Hyperuricemia
Administration
May be taken with or without food. May be taken w/o regard to antacid use.
Adult Dose
Chronic Gout
40 mg/day PO initially; maintenance: 40-80 mg/day; increased if serum uric acid is >6 mg/mL after 2 weeks
Hepatic impairment
Mild to moderate (Child-Pugh class A or B): Dosage adjustment not necessary
Severe (Child-Pugh class C): Data not available; use with caution
Child Dose
Safety and efficacy not established
Renal Dose
Renal impairment
Mild to moderate (CrCl 30-89 mL/min): Dosage adjustment not necessary
Severe (CrCl <30 mL/min): Data not available; use with caution
Contraindication
Patients being treated with azathioprine, mercaptopurine, or theophylline.
Mode of Action
Febuxostat selectively inhibits xanthine oxidase, the enzyme that catalyses the conversion of hypoxanthine to xanthine to uric acid, thereby decreasing serum concentrations of uric acid.
Precaution
Cardiovascular death Patients with established cardiovascular (CV) disease treated with febuxostat had a higher rate of CV death compared with those treated with allopurinol in a CV outcomes study. Evaluate risks and benefits when prescribing febuxostat or continuing treatment. Gout Flare: An increase in gout flares is frequently observed during initiation of anti-hyperuricemic agents, including Febustat. If a gout flare occurs during treatment, Febustat need not be discontinued. Prophylactic therapy (i.e., non-steroidal anti-inflammatory drug (NSAID) or colchicine upon initiation of treatment) may be beneficial for up to six months. Lactation: Unknown whether drug is excreted into breast milk; use with...
... Show moreSide Effect
>1%
Arthralgia,Elevated liver function test (LFT) results,Liver function abnormalities,Nausea,Rash
Pregnancy Category Note
Pregnancy Limited available data in pregnant women are insufficient to inform a drug associated risk of adverse developmental outcomes Animal data No adverse developmental effects observed in embryo-fetal development studies with oral administration of febuxostat to pregnant rats and rabbits during organogenesis at doses that produced maternal exposures up to 40 and 51 times, respectively, the exposure at the maximum recommended human dose (MRHD) No adverse developmental effects observed in a pre- and postnatal development study with administration of febuxostat to pregnant rats from organogenesis through lactation at an exposure ~11 times the MRHD Lactation There are no data on...
... Show moreInteraction
May increase plasma conc of mercaptopurine, azathioprine. Alteration of metabolism of xanthine oxidase substrate drugs (eg theophylline).
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