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Safety Advices
বাংলা
English
SAFE
Consuming alcohol with Erpen does not cause any harmful side effects.
SAFE IF PRESCRIBED
Erpen is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
SAFE IF PRESCRIBED
Erpen is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
UNSAFE
Erpen may cause side effects which could affect your ability to drive.
Certain side effects, such as dizziness and sleepiness, have been reported with Erpen, which may affect some patients’ ability to drive or operate machinery
CAUTION
Erpen should be used with caution in patients with kidney disease. Dose adjustment of Erpen may be needed. Please consult your doctor.
SAFE IF PRESCRIBED
Erpen is safe to use in patients with liver disease. No dose adjustment of Erpen is recommended.
Medicine Overview of Erpen 1gm/vial Injection
Introduction
Erpen is an antibiotic belonging to the carbapenem group that fights bacteria. It is used to treat severe infections of the skin, lungs, stomach, urinary tract, blood and brain (eg. meningitis). It works by killing the bacteria that cause these problems. Erpen is commonly used to treat seriously ill patients admitted to the hospital. This medicine is given by drip or by direct injection into a vein, under the supervision of a healthcare professional. The dose depends on what type of infection you have, where it is in the body and how serious it is. You should have your injections...
... Show moreUses of Erpen
- Bacterial infections
Side effects of Erpen
Common
- Injection site reactions (pain, swelling, redness)
- Vomiting
- Nausea
How to use Erpen
Your doctor or nurse will give you this medicine. Kindly do not self administer.
How Erpen works
Erpen is an antibiotic. It kills bacteria by preventing them from forming the bacterial protective covering (cell wall) which is needed for them to survive.
What if you forget to take Erpen?
If you miss a dose of Erpen, please consult your doctor.
Quick Tips
- Erpen is an antibiotic that's usually only given in the hospital for serious infections.
- It is given by a drip into a vein (intravenous infusion) over 20 to 60 minutes.
- Inform your doctor if you are allergic to penicillin or if you are taking any seizure medication before starting treatment with this medication.
- Diarrhea may occur as a side effect. Inform your doctor if you develop severe stomach pain or if you find blood in your stools.
- Your doctor may monitor your liver and kidney function while you are having treatment with this medication.
Brief Description
Indication
Intra-abdominal infections, Community-acquired pneumonia, Skin and skin structure infections, Urinary tract infections, Pyelonephritis, Surgical infections, Diabetic foot infections, Septic abortion
Administration
IV Preparation
Reconstitute 1 g vial with 10 mL SWI, NS, or BWI; shake well; transfer to 50 mL NS
IV Administration
Infuse over 30 minutes
IM Preparation
Reconstitute 1 g vial with 3.2 mL of 1% lidocaine injection (without epinephrine); shake well; use within 1 hour after preparation
IM Administration
Make sure patient does not have allergy to lidocaine or another amide anesthetic
Administer by deep IM injection into large muscle mass (eg, gluteal muscle or lateral part of thigh)
Do not administer IM preparation or drug reconstituted for IM administration IV
Adult Dose
Community-Acquired Pneumonia 1 g/day IV/IM up to 14 days; after ?3 days of parenteral therapy, may be switched to appropriate PO regimen if patient improves clinically Complicated Urinary Tract Infections (Including Pyelonephritis) 1 g/day IV/IM up to 14 days; after ?3 days of parenteral therapy, may be switched to appropriate PO regimen if patient improves clinically Acute Pelvic Infections 1 g/day IV/IM for 3-10 days Complicated Intra-abdominal Infections 1 g/day IV/IM for 5-14 days Complicated Skin/Skin Structure Infections 1 g/day IV/IM for 7-14 days; may be continued up to 4 weeks for diabetic foot infections, depending on severity of infection...
... Show moreChild Dose
Community-Acquired Pneumonia, Complicated Urinary Tract Infections (Including Pyelonephritis)
3-12 years: 15 mg/kg IV/IM q12hr up to 14 days; not to exceed 1 g q12hr; after ?3 days of parenteral therapy, may be switched to appropriate PO regimen if patient improves clinically
>12 years: 1 g/day IV/IM up to 14 days; after ?3 days of parenteral therapy, may be switched to appropriate PO regimen if patient improves clinically
Complicated Intra-abdominal Infections, Complicated Skin/Skin Structure Infections
3-12 years: 15 mg IV/IM q12hr for 7-14 days
>12 years: 1 g/day IV/IM for 7-14 days
<3 years: Safety and efficacy not established
Renal Dose
Renal impairment
CrCl >30 mL/min/1.73 m²: Dosage adjustment not necessary
CrCl <30 mL/min/1.73 m² and end-stage renal disease (ESRD): 500 mg/day IV
Dialysis: 500 mg/day IV; if given ?6 hr before dialysis, supplemental dose of 150 mg afterward
Contraindication
Hypersensitivity; lactation.
Mode of Action
Ertapenem acts similarly to penicillins by bacterial cell wall inhibition. It is active against many gram-negative and aerobic and anaerobic organisms. It is stable to hydrolysis by beta-lactamases.
Precaution
Hypersensitivity to penicillins, cephalosporins or other beta-lactams (possibility of cross-sensitivity). Renal impairment; CNS disorders e.g. epilepsy. Pregnancy.
Lactation: Drug distributed in breast milk; use with caution
Side Effect
>10%
Diarrhea (2-12%)
1-10%
Elevated liver function tests (LFTs) (7-9%),Nausea (6-9%),Headache (6-7%),Infused vein complications (5-7%),Increased platelet count (4-7%),Increased alkaline phosphatase (4-7%),Altered mental status (3-5%),Fever (2-5%),Abdominal pain (4%),Vomiting (4%),Constipation (3-4%),Insomnia (3%),Swelling or edema (3%),Drug rash with eosinophilia and systemic symptoms (DRESS syndrome) (2-3%),Rash (2-3%),Vaginitis (1-3%),Dizziness (2%),Phlebitis or thrombophlebitis (1.5-2%),Pruritus (1-2%),Tachycardia (1-2%),Acid regurgitation (1-2%),Eosinophilia (1-2%),Hypotension (1-2%),Erythema (1-2%),Hypertension (0.7-2%),Chest pain (1%),Dyspepsia (1%),Fatigue (1%),Anxiety (0.8-1%),Oral candidiasis (0.1-1%)
Potentially Fatal: Pseudomembranous colitis, Stevens-Johnson syndrome.
Pregnancy Category Note
Pregnancy Available data from a small number of postmarketing cases with use in pregnancy are insufficient to inform any drug-associated risks for major birth defects, miscarriage, or adverse maternal or fetal outcomes Animal data In animal reproduction studies after intravenous administration of ertapenem during period of organogenesis, there was no evidence of developmental malformations in rats at systemic exposures (AUC) up to approximately 1.2 times the human exposure at maximum recommended human dose (MRHD) and in mice at doses up to approximately 3 times MRHD based on body surface area comparison; in pregnant rats administered ertapenem during organogenesis through lactation,...
... Show moreInteraction
May decrease plasma levels of valproic acid thus, increasing the risk of seizures. Increased plasma concentrations w/ probenecid.
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