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Medicine Overview of Thiason 100mg/ml IM/IV Injection
বাংলা
English
Indication
Beriberi and Wernick's encephalopathy, neuritis associated with pregnancy and pellagra.
Administration
Should be taken with food.
Adult Dose
Treatment and prophylaxis of mild chronic thiamine deficiency
Adult: 10-25 mg daily in single or divided doses.
Thiamine deficiency
Adult: 1 tablet (100mg) daily, up to 300 mg daily.
Wernicke-Korsakoff syndrome
Adult: Initially, 100 mg by slow IV Inj over 10 min, then 50-100 mg/day IM or IV until the patient can take oral thiamine.
Child Dose
Thiamine deficiency
10-50 mg/day PO in divided doses
Beriberi
10-25 mg IV/IM qDay (if crtically ill) or 10-50 mg/dose PO qDay for at least 2 weeks, THEN
5-10 mg/day PO for 1 month
Contraindication
Hypersensitivity
Mode of Action
Thiamine, a water soluble vitamin, combines with ATP to form thiamine pyrophosphate, an essential coenzyme in carbohydrate metabolism.
Precaution
Parenteral admin. Increased daily requirements in pregnancy and lactation.
Side Effect
IV: Warm sensation, tingling, pruritus, pain, urticaria, weakness, sweating, nausea, restlessness, tightness of the throat, angioedema, respiratory distress, cyanosis, pulmonary oedema, GI bleeding, transient vasodilation and hypotension, vascular collapse.
IM: Tenderness and induration.
Potentially Fatal: Very rarely, fatal anaphylactic shock.
Interaction
May enhance the effect of neuromuscular blocking agents.
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