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Lok 50 Plus
Globe Pharmaceuticals Ltd.
Generic: Hydrochlorothiazide + Losartan Potassium
Safety Advices
বাংলা
English
UNSAFE
It is unsafe to consume alcohol with Lok 50 Plus.
CONSULT YOUR DOCTOR
Lok 50 Plus is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
SAFE IF PRESCRIBED
Lok 50 Plus is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
UNSAFE
Lok 50 Plus may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
CAUTION
Lok 50 Plus should be used with caution in patients with severe kidney disease. Dose adjustment of Lok 50 Plus may be needed. Please consult your doctor.
Use of Lok 50 Plus is not recommended in patients with severe kidney disease.
CAUTION
Lok 50 Plus should be used with caution in patients with liver disease. Dose adjustment of Lok 50 Plus may be needed. Please consult your doctor.
Medicine Overview of Lok 50 Plus 12.5mg+50mg Tablet
Introduction
Lok 50 Plus is a combination of two medicines. It helps to control high blood pressure in different ways. If high blood pressure is not treated it can lead to heart attacks, strokes and kidney failure. You can take Lok 50 Plus with or without food. The dose will depend on your condition and how your respond to the medicine. Try to take it at the same time each day. It is important to keep taking this medicine until your doctor tells you not to. It contains a diuretic (water pill) and will make you urinate more so, it is...
... Show moreUses of Lok 50 Plus
- Hypertension (high blood pressure)
Side effects of Lok 50 Plus
Common
- Nausea
- Taste change
- Upset stomach
- Diarrhea
- Headache
- Dizziness
- Weakness
- Decreased blood pressure
- Increased blood uric acid
- Increased blood lipid level
- Glucose intolerance
- Electrolyte imbalance
How to use Lok 50 Plus
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Lok 50 Plus may be taken with or without food, but it is better to take it at a fixed time.
How Lok 50 Plus works
Lok 50 Plus is a combination of two medicines: Losartan and Hydrochlorothiazide, which lowers the blood pressure effectively. Losartan is an angiotensin receptor blocker (ARB). It works by blocking the hormone angiotensin thereby relaxing blood vessels. This allows the blood to flow more smoothly and the heart to pump more efficiently. Hydrochlorothiazide is a diuretic that removes extra water and certain electrolytes from the body. Over time it also relaxes blood vessels and improves blood flow.
Quick Tips
- You have been prescribed Lok 50 Plus for the treatment of high blood pressure.
- It can be taken with or without food.
- Lok 50 Plus may cause dehydration. Drink plenty of fluids and inform your doctor if you develop extreme thirst, very dry mouth or muscle weakness.
- It may cause dizziness. Get up slowly when rising from a sitting or lying position.
- Use of Lok 50 Plus during pregnancy or breastfeeding is unsafe.
- It may also decrease the risk of stroke and heart attacks.
Brief Description
Indication
Hypertension, Stroke, risk reduction of hypertensive or LVH patients
Adult Dose
Hypertension
Initial: 50 mg/12.5 mg PO qDay
If dose titrated upward, do not to exceed final titration of 100 mg/25 mg PO qDay or 50 mg/12.5 mg PO q12hr
Decrease losartan to 25 mg PO qDay initially if volume depleted
Child Dose
Safety and efficacy not established
Renal Dose
Renal impairment
CrCl 30 mL/min: No dosage adjustment required
Contraindication
Pregnancy, lactation; intravascular volume depletion.
Mode of Action
Hydrochlorothiazide increases renal excretion of sodium and chloride and reduces cardiac load. Losartan is an angiotensin II receptor (type AT1) antagonist antihypertensive which acts by blocking the actions of angiotensin II of renin-angiotensin-aldosterone system. The drug and its active metabolite selectively block the vasoconstrictor and aldosterone secreting effects of angiotensin II. The two drugs exert additive effects in hypertension.
Precaution
Existing electrolyte disturbances; hepatic cirrhosis; severe hepatic failure; oedema; elderly (>75 yr); renal impairment; hepatic impairment; diabetes, gout, hyperlipidaemia; hyperuricaemia; ECG: LVH and/or ventricular ectopics extrasystoles); volume depleted patients; patients on diuretics and salt restriction; renal artery stenosis; aortic and mitral stenosis. Monitor potassium concentration. Discontinue before performing tests for parathyroid function.
Lactation: Discontinue drug or do not nurse
Side Effect
>10%
Losartan
Fatigue (14%),Hypoglycemia (14%),Chest pain (12%),Cough, incidence higher in previous cough related to ACE therapy (3-11%)
1-10%
Losartan
Diarrhea (2-10%),URI (8%),Hypotension (7%),Dizziness (4%),Nausea (2%)
Hydrochlorothiazide
Hypotension,Anorexia,Epigastric distress,Hypokalemia,Phototoxicity,Thrombocytopenia
Potentially Fatal: Hypersensitivity reactions; hemolytic anaemia; toxic epidermal necrolysis.
Interaction
Reduced excretion of lithium; effect of diuretic, natriuretic & other antihypertensive w/ NSAIDs including selective COX-2 inhibitors. Do not co-administer w/ aliskiren in patients w/ diabetes & renal impairment. Losartan: Rifampin & fluconazole. Increased serum potassium w/ K-sparing diuretics (eg spironolactone, triamterene, amiloride), K supplements or salt substitutes containing K. Hydrochlorothiazide: Potentiate orthostatic hypotension w/ alcohol, barbiturates or narcotics. Antidiabetic drugs (oral agents, insulin), other antihypertensive drugs. Impaired absorption w/ cholestyramine & colestipol resins. Intensified electrolyte depletion w/ corticosteroids, ACTH, glycyrrhizin (liquorice). Possible decreased response to pressor amines (eg adrenaline); increased response to nondepolarizing skeletal muscle relaxants (eg tubocurarine). May...
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