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Aloxif
Incepta Pharmaceuticals Ltd.
Generic: Raloxifene Hydrochloride
Safety Advices
বাংলা
English
CAUTION
Caution is advised when consuming alcohol with Aloxif. Please consult your doctor.
UNSAFE
Aloxif is highly unsafe to use during pregnancy. Seek your doctor's advice as studies on pregnant women and animals have shown significant harmful effects to the developing baby.
UNSAFE
Aloxif is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
SAFE
Aloxif does not usually affect your ability to drive.
CAUTION
Aloxif should be used with caution in patients with kidney disease. Dose adjustment of Aloxif may be needed. Please consult your doctor.
Use of Aloxif is not recommended in patients with severe kidney disease.
UNSAFE
Aloxif is probably unsafe to use in patients with liver disease and should be avoided. Please consult your doctor.
Medicine Overview of Aloxif 60mg Tablet
Introduction
Aloxif is a medicine used in the treatment and prevention of osteoporosis in postmenopausal women. It helps in preventing bone loss that can develop in women after menopause. It makes the bone stronger and lowers the risk of fractures. Aloxif can be taken with or without food. Take it regularly and do not stop taking the medicine even if you get better until that doctor tells you it is alright to stop. Along with taking the medicine, exercise regularly to strengthen muscles around the affected joint and manage your weight. You should also avoid smoking and excessive consumption of alcohol...
... Show moreUses of Aloxif
- Osteoporosis
Side effects of Aloxif
Common
- Leg cramps
- Peripheral edema
- Flu-like symptoms
- Joint pain
- Sweating
How to use Aloxif
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Aloxif may be taken with or without food, but it is better to take it at a fixed time.
How Aloxif works
Aloxif works like estrogen, a natural female hormone to stop the bone loss that can develop in women after menopause.
Quick Tips
- Inform your doctor if you have if you have any type of cancer, heart failure, kidney disease, high triglycerides or liver disease.
- Inform your doctor if you are on estrogen therapy.
- Do not take calcium supplements unless advised by doctor. Taking calcium supplements more than recommended will not provide extra protection for your bones but may cause adverse side effects including kidney stones.
- Stop using raloxifene immediately if you develop: lumps in the breast, signs of stroke (sudden numbness or weakness), severe headache, slurred speech, vision problems; chest pain, sudden cough, wheezing, rapid breathing, coughing up blood; or pain, swelling, warmth, or redness in one or both legs.
- Avoid sitting still for long periods of time while you are taking raloxifene.
- Inform your doctor immediately if you observe bleeding / spotting from vagina during the treatment.
- Tell your doctor if you are or planning to become pregnant or are breastfeeding.
Brief Description
Indication
Post-menopausal osteoporosis, Malignant gastrointestinal stromal tumours, Prevention & risk reduction of invasive breast cancer
Administration
May be taken with or without food.
Adult Dose
Oral
Prophylaxis of postmenopausal osteoporosis; Osteoporosis in postmenopausal women
Adult: 60 mg once daily.
Breast Cancer
Prevention; risk reduction of invasive breast cancer in postmenopausal women at high risk for invasive breast cancer
60 mg PO qDay for 5 years
Hepatic impairment: Contraindicated.
Renal Dose
Renal impairment: Severe: Contraindicated.
Contraindication
Active or history of venous thromboembolic events including DVT, pulmonary embolism, retinal vein thrombosis. Unexplained uterine bleeding. Patients w/ signs/symptoms of endometrial cancer. Hepatic (including cholestasis) and severe renal impairment. Pregnancy, women who may become pregnant, and lactation.
Mode of Action
Raloxifene is a selective oestrogen receptor modulator that has both selective agonist or antagonist activities on oestrogen receptors. It acts as an agonist on bone by preventing bone loss and partially on cholesterol metabolism by decreasing total and LDL cholesterol levels but antagonises oestrogen effects leading to development of breast and uterine cancer.
Precaution
Women w/ risk factors for venous thromboembolism including CHF or active malignancy, risk factors for stroke (e.g. TIA, AF), history of oestrogen-induced hypertriglyceridaemia. Moderate renal impairment. Monitoring Parameters Monitor serum triglyceride concentration.
Lactation: Excretion in milk unknown; contraindicated
Side Effect
>10%
Hot flashes (8-29%),Flu syndrome (14-15%),Cramps/muscle spasm (6-12%),Arthralgia (11-16%),Infection (11%)
1-10%
Insomnia (6%),Vomiting (5%),Sinusitis (10%),Venous thromboembolism (1-2% ),Bronchitis (10%),Pharyngitis (8%),Breast pain (4%),Gastroenteritis (<3%),Diaphoresis (3%)
Frequency Not Defined
Deep vein thrombosis,Cerebrovascular accident,Thrombosis of retinal vein (rare),Pulmonary embolism,Decreased fibrinogen
Interaction
Cholestyramine reduces the absorption of raloxifene. Raloxifene with warfarin may reduce the prothrombin response and time. Caution when used in hghly protein-bound drugs such as diazepam, lidocaine and diazoxide.
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