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Berdinal
Gaco Pharmaceuticals(G.A Company Ltd)
Generic: Phenobarbitone Sodium inj
Safety Advices
বাংলা
English
UNSAFE
It is unsafe to consume alcohol with Berdinal.
CONSULT YOUR DOCTOR
Berdinal is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
CONSULT YOUR DOCTOR
Berdinal is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Monitor the baby for sleepiness, skin rash, and feeding issues.
UNSAFE
Berdinal may cause side effects which could affect your ability to drive.
CAUTION
Berdinal should be used with caution in patients with kidney disease. Dose adjustment of Berdinal may be needed. Please consult your doctor.
Use of Berdinal is not recommended in patients with severe kidney disease.
CAUTION
Berdinal should be used with caution in patients with liver disease. Dose adjustment of Berdinal may be needed. Please consult your doctor.
Use of Berdinal is not recommended in patients with severe liver disease.
Medicine Overview of Berdinal 200mg/ml Injection
Introduction
Berdinal belongs to a class of medicines called barbiturates. It is a prescription medicine used to treat and prevent epilepsy (seizures). They also have hypnotic properties. Means, they slow down the activity of the brain and can make you feel sleepy or dizzy. Berdinal may be taken with or without food. However, it is advised to take it at the same time each day as this helps to maintain a consistent level of medicine in the body. Take this medicine in the dose and duration as advised by your doctor as it may be habit-forming with long-term use. If you...
... Show moreUses of Berdinal
- Epilepsy/Seizures
Side effects of Berdinal
Common
- Drowsiness
- Nausea
- Diarrhea
- Hyperactivity
- Depression
- Confusion
- Decreased blood pressure
- Fatigue
- Headache
- Dizziness
- Constipation
- Excitement
- Hangover
How to use Berdinal
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Berdinal may be taken with or without food, but it is better to take it at a fixed time.
How Berdinal works
Berdinal controls seizures or fits by increasing the action of GABA, a chemical messenger which suppresses the abnormal and excessive activity of the nerve cells in the brain.
Quick Tips
- Berdinal helps in treatment and prevention of seizures.
- It may be habit-forming with long-term use.
- Talk with your doctor if it stops working well. Do not take more than prescribed.
- It may make you very sleepy. Don't drive or do anything that requires mental focus until you know how it affects you.
- Inform your doctor if you notice pain in your joints or if you have a history of bone disease.
- Get regular blood tests done to monitor the amount of medication in your body.
- Talk to your doctor immediately if you notice skin rash accompanied with fever.
- Do not stop taking the medication suddenly without talking to your doctor.
Brief Description
Indication
Status epilepticus, Partial seizures, Sedation, Generalised tonic-clonic seizures, Hypnotic, Preoperative sedation
Administration
Reconstitution:
Dilute w/ most IV infusion soln (e.g. NaCl 0.45% or 0.9%, lactated Ringer's, dextrose 5%, Ringer's).
IV Administration
Slow injection at <60 mg/min
May be given IM into large muscle
Adult Dose
Parenteral
Status epilepticus ; Emergency management of acute seizures
Adult: As phenobarbital Na: 200-600 mg. OR 15-18 mg/kg IV loading dose infused at 25-60 mg/min; prepare to support ventilation; may repeat in 20-minute intervals PRN; not to exceed 30 mg/kg
As a hypnotic
Adult: 100-320 mg. Do not admin for >2 wk for the treatment of insomnia.
Intramuscular
Preoperative sedation
Adult: As phenobarbital Na: 100-200 mg 60-90 min pre-op.
Hepatic impairment: Reduce dose. Severe: Contraindicated.
Child Dose
Parenteral
Status epilepticus ; Emergency management of acute seizures
Child: As phenobarbital Na: 100-400 mg. OR
Infants and children: 15-20 mg/kg IV infused at a rate not to exceed 2 mg/kg/min; not to exceed 1000 mg/dose
12 years: 1-3 mg/kg/day in 1-2 divided doses, OR 50-100 mg BID/TID
Intramuscular
Preoperative sedation
Child: As phenobarbital Na: 16-100 mg 60-90 min pre-op.
Intravenous
Preoperative sedation
Child: 1-3 mg/kg pre-op.
Renal Dose
Renal impairment: Reduce dose. Severe: Contraindicated.
Contraindication
Severe renal and hepatic disorders. Severe respiratory depression, dyspnoea or airway obstruction; porphyria. Pregnancy.
Mode of Action
Phenobarbitone is a short-acting barbiturate. It depresses the sensory cortex, reduces motor activity, changes cerebellar function, and produces drowsiness, sedation and hypnosis. Its anticonvulsant property is exhibited at high doses.
Precaution
Patient w/ history or sedative/hypnotic addiction; resp disease, depression or suicidal tendencies, hypoadrenalism. Avoid abrupt withdrawal. Mild to moderate renal and hepatic impairment. Elderly or debilitated patient, childn. Pregnancy and lactation. Patient Counselling May impair ability to drive or operate machinery. Monitoring Parameters Monitor CBC, LFTs, mental status and seizure activity.
Lactation: Do not nurse
Side Effect
Common
Ataxia,Dizziness,Drowsiness,Dysarthria,Fatigue,Headache,Irritability,Nystagmus,Paresthesia restlessness,Vertigo
Geriatric patients: Excitement, confusion, depression
Pediatric patients: Paradoxical excitement/hyperactivity
Less Common
Mental dullness,Constipation,Diarrhea,Nausea,Vomiting,Megaloblastic (folate-deficiency) anemia
Uncommon
Rash,Hypocalcemia,Hepatotoxicity
Rare
Stevens-Johnson syndrome,Rickets,Osteomalacia
Potentially Fatal: Stevens-Johnson syndrome.
Interaction
May enhance the hepatotoxic potential of paracetemaol overdoses. May decrease levels/effects of various CYP isoenzyme substrates e.g. teniposide, methotrexate, antipsychotics, beta-blockers, calcium-channel blockers, other anticonvulsants, chloramphenicol, cimetidine, corticosteroids, ciclosporin, doxycycline, oestrogens, felbamate, griseofulvin, tacrolimus, furosemide, methadone, oral contraceptives, theophylline, TCAs, warfarin. May reduce effects of guanfacine. Reduced metabolism and or increased toxicity with chloramphenicol, felbamate, MAOIs, valproic acid. May enhance the nephrotoxic effects of methoxyflurane.
Potentially Fatal: Additive sedation and/or respiratory depression with ethanol, sedatives, antidepressants, opioid analgesics, benzodiazepines and other CNS depressants. May decrease levels/effects of antiarrhythmic drugs e.g. disopyramide, propafenone, quinidine.
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