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Safety Advices
বাংলা
English
UNSAFE
It is unsafe to consume alcohol with Premil.
CONSULT YOUR DOCTOR
Premil may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
SAFE IF PRESCRIBED
Premil is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
Monitor the breastfed baby’s blood sugar during treatment with Premil
CAUTION
Your ability to drive may be affected if your blood sugar is too low or too high. Do not drive if these symptoms occur.
CAUTION
Premil should be used with caution in patients with severe kidney disease. Dose adjustment of Premil may be needed. Please consult your doctor.
CAUTION
Premil should be used with caution in patients with liver disease. Dose adjustment of Premil may be needed. Please consult your doctor.
Use of Premil is not recommended in patients with severe liver disease.
Medicine Overview of Premil 0.5mg Tablet
Introduction
Premil is used to lower blood sugar levels in adults with type 2 diabetes mellitus. It is usually prescribed along with other diabetes medicines to achieve adequate blood sugar control. It also prevents serious complications of diabetes like kidney damage and blindness. Premil is normally prescribed when diet and exercise alone or other medicines have not been enough to control your blood sugar level. It works best when taken before meals. The dose will depend on your condition, and blood sugar levels, but you should use it as advised by your doctor. You should take it regularly, at the same...
... Show moreUses of Premil
- Type 2 diabetes mellitus
Side effects of Premil
Common
- Joint pain
- Dizziness
- Back pain
- Diarrhea
- Flu-like symptoms
- Upper respiratory tract infection
How to use Premil
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Premil is to be taken empty stomach.
How Premil works
Premil is an anti-diabetic medication. It increases the amount of insulin released by the pancreas which prevents blood glucose from rising very high after meals.
What if you forget to take Premil?
If you miss a dose of Premil, skip it and continue with your normal schedule. Do not double the dose.
Quick Tips
- For best results, take Premil 15 to 30 minutes before a meal.
- You should continue to exercise regularly, eat a healthy diet, and take your other diabetes medicines along with Premil
- It may cause dizziness. Do not drive or do anything that requires mental focus until you know how Premil affects you.
- It may cause hypoglycemia (low blood sugar level) when used with other antidiabetic medicines, alcohol or if you delay or miss a meal.
- Always carry some sugary food or fruit juice with you in case you experience hypoglycemic symptoms such as cold sweats, cool pale skin, tremor, and anxiety.
- Monitor your blood sugar levels regularly while you are taking this medicine.
- Inform your doctor if you are pregnant, planning pregnancy or breastfeeding.
Brief Description
Indication
Type 2 DM
Administration
Take 15 minutes before meal; no more than 4 meals/day
Adult Dose
Oral
Type 2 diabetes mellitus
Adult: Usual initial dose: 0.5 mg before main meals.
Initial doses of 1 or 2 mg may be used in patients who have had previous hypoglycaemic treatment.
May adjust dose at intervals of 1-2 wk, up to 4 mg before meals.
Max dose: 16 mg daily.
Hepatic impairment: May require longer intervals between dosage adjustments.
Child Dose
Safety and efficacy not established
Renal Dose
Renal Impairment
CrCl 40-80 mL/minute: No adjustments necessary
CrCl 20-40 mL/minute: 0.5 mg with meals; titrate slowly and monitor
CrCl < 20 mL/minute: Data not available
Contraindication
Diabetic ketoacidosis; severe hepatic impairment, type 1 diabetes; hypersensitivity. Lactation.
Mode of Action
Repaglinide stimulates release of insulin from pancreatic beta-cells by inhibiting K efflux via closure of ATP regulated K channels. This results in depolarization of the cell and opening of voltage-dependent Ca channels, which increases influx of Ca into the beta cells and causes release of insulin.
Precaution
Myocardial infarction, coma, trauma during surgery, elderly, malnourished and debilitated patients. Hepatic or severe renal impairment. Pregnancy.
Side Effect
Hypoglycaemia, nausea, diarrhoea, constipation, vomiting, dyspepsia, arthralgia, sinusitis, rhinitis, back pain; rash, pruritus, urticaria; visual disturbances.
Interaction
Cytochrome P450 3A4 inducers eg. rifampicin, barbiturates and carbamazepine may increase repaglinide metabolism. NSAIDs and other highly protein bound drugs eg, salicylates, sulphonamides, phenylbutazone, oral anticoagulants and hydantoins may potentiate action of repaglinide. Ketoconazole, fluconazole, itraconazole and erythromycin may increase plasma conc of repaglinide. Antagonistic effect with drugs causing hyperglycaemia. Concurrent use with gemfibrozil may lead to enhanced and prolonged blood glucose lowering effect.
Potentially Fatal: Increased risk of myocardial infarction when used with isophane insulin.
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