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Symbiotrin
NIPRO JMI Pharma Limited
Generic: Miconazole 2% Oral Gel
Safety Advices
বাংলা
English
CONSULT YOUR DOCTOR
Symbiotrin may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
SAFE IF PRESCRIBED
Symbiotrin is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.
Medicine Overview of Symbiotrin 2% Oral Gel
Introduction
Symbiotrin is an antifungal medicine used to treat fungal infections of the skin. It works by killing the fungus that causes infections such as athlete’s foot, Dhobie Itch, thrush, ringworm and dry, flaky skin. Symbiotrin should be used in the dose and duration as prescribed by your doctor. This medicine should be used regularly to get the most benefit from it. Do not use more than you needed, it will not clear your condition faster and may only increase the side effects. Skin infections will usually get better after 2 to 6 weeks. Do not use the medicine for longer...
... Show moreUses of Symbiotrin
- Fungal skin infections
Side effects of Symbiotrin
Common
- Application site reactions (burning, irritation, itching and redness)
How to use Symbiotrin
This medicine is for external use only. Use it in the dose and duration as advised by your doctor. Check the label for directions before use. Clean and dry the affected area and apply the gel. Wash your hands after applying, unless hands are the affected area.
How Symbiotrin works
Symbiotrin is an antifungal medication which treats skin infections. It works by killing the fungi on the skin by destroying their cell membrane.
What if you forget to take Symbiotrin?
If you miss a dose of Symbiotrin, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
- Your doctor has prescribed Symbiotrin to cure your infection and improve symptoms.
- Some tips for personal hygiene:
- Apply an amount sufficient to cover the affected area and 1 inch of the immediate surrounding skin.
- Treatment may be needed for 2 to 6 weeks for skin infections and 6 weeks to 6 months for nail infections.
- Do not skip any doses and finish the full course of treatment even if you feel better.
- Avoid getting it in the eyes, nose, or mouth. If accidental exposure occurs, rinse immediately with plenty of water.
- Inform your doctor if you are pregnant, planning pregnancy or breastfeeding.
Brief Description
Indication
Oropharyngeal candidiasis, Oral thrush, Denture stomatitis, Fungal infections of the mouth, Throat and gut, Angular cheilitis, Dermatomycoses, Tinea pedis, Tinea corporis, Tinea cruris, Tinea versicolor
Administration
Apply on oral lesions and retain in the mouth as long as possible before swallowing. For localised lesions of the mouth, a small amount of gel may be applied directly to the affected area with a clean finger.
Adult Dose
Mouth/Throat
Oropharyngeal candidiasis, Intestinal candidiasis
Adult: The usual dose is 15 mg/kg/day in divided doses.
One or two tea spoonfuls (5-10 ml) of gel four times daily.
Continue treatment for at least 1 wk after symptoms have disappeared.
Localised lesions of mouth: Smear small amount on affected area with clean finger 4 times daily for 5-7 days.
Child Dose
Mouth/Throat
Oropharyngeal candidiasis
Children aged 6 years and over: One tea-spoonful (5 ml) of gel four times daily.
Children aged 2-6 years: One tea-spoonful (5 ml) of gel twice daily.
Infants under 2 years: Half tea-spoonful (2.5 ml) of gel twice daily.
Continue treatment for at least 1 wk after symptoms have disappeared.
Localised lesions of mouth: Smear small amount on affected area with clean finger 4 times daily for 5-7 days.
Contraindication
Miconazole Oral Gel is contraindicated in patients with known hypersensitivity to any of its components and in patients with liver dysfunction.
Mode of Action
Miconazole inhibits ergosterol synthesis thus damaging fungal cell wall membrane and increases its permeability, allowing leakage of nutrients.
Precaution
Caution is required particularly in infants & young children to ensure that the gel does not obstruct the throat.
Lactation: Unknown whether distributed in breast milk, caution advised
Side Effect
1-10%
Diarrhea (6%),Nausea (4.6%),Headache (5%),Dysgeusia (2.9%),Upper abdominal pain (2.5%),Vomiting (2.5%)
Interaction
May increase anticoagulant effect of warfarin. May increase or prolong the effect of the following drugs: Oral hypoglycaemics (e.g. sulfonylureas), phenytoin, HIV protease inhibitors (e.g. saquinavir), antineoplastic agents (e.g. vinca alkaloids, busulfan, docetaxel), Ca channel blockers (e.g. dihydropyridines, verapamil), immunosuppressive agents (e.g. ciclosporin, tacrolimus, sirolimus), carbamazepine, cilostazol, buspirone, disopyramide, alfentanil, sildenafil, alprazolam, brotizolam, midazolam IV, rifabutin, methylprednisolone, trimetrexate, ebastine and reboxetine. Potentially Fatal: Increased risk of cardiac arrhythmia w/ astemizole, cisapride, dofetilide, halofantrine, mizolastine, pimozide, quinidine, sertindole, terfenadine. May increase exposure to ergot alkaloids leading to ergotism. May increase the risk of rhabdomyolysis w/ HMG-CoA reductase inhibitors (e.g. simvastatin and...
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