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Safety Advices
বাংলা
English
UNSAFE
Consuming alcohol while taking Servizid may cause symptoms such as flushing, increased heart beat, nausea, thirst, chest pain and low blood pressure (Disulfiram reaction).
CONSULT YOUR DOCTOR
Servizid may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
SAFE IF PRESCRIBED
Servizid is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.
UNSAFE
Servizid may cause side effects which could affect your ability to drive.
Servizid can cause fits, mental health problems and optic neuritis (inflammation of the optic nerve that may cause loss of vision.) This may affect your driving ability.
SAFE IF PRESCRIBED
Servizid is safe to use in patients with kidney disease. No dose adjustment of Servizid is recommended.
However, talk to your doctor if you have any underlying kidney disease.
CAUTION
Servizid should be used with caution in patients with liver disease. Dose adjustment of Servizid may be needed. Please consult your doctor.
Use of Servizid is not recommended in patients with severe liver disease.
Medicine Overview of Servizid 300mg Tablet
Introduction
Servizid is an antibiotic used for the treatment and prevention of tuberculosis (TB) and inactive (latent) TB (a serious infection caused by bacteria that affects the lungs and in certain cases other parts of the body). It works by killing the bacteria that cause tuberculosis. Servizid should be used in the dose and duration as advised by your doctor. It is to be taken on an empty stomach. Do not skip any doses and finish the full course of treatment even if you feel better. Stopping it early can result in treatment failure and increase the side effects too. Do...
... Show moreUses of Servizid
- Tuberculosis (TB)
Side effects of Servizid
Common
- Peripheral neuropathy (tingling and numbness of feet and hand)
- Increased liver enzymes
- Hepatitis (viral infection of liver)
- Jaundice
How to use Servizid
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Servizid is to be taken empty stomach.
Avoid Servizid with tyramine-rich food such as cheese, smoked fish, meats and some types of beer.
How Servizid works
Servizid is an antibiotic. It works by killing the bacteria that causes tuberculosis.
What if you forget to take Servizid?
If you miss a dose of Servizid, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
- Your doctor has prescribed Servizid to cure your infection and improve symptoms.
- It is best taken on an empty stomach.
- You must also take a vitamin B6 supplement while on Servizid.
- Tell your doctor immediately if you experience vision changes, loss of appetite, tiredness, stomach pain, nausea or vomiting, yellow skin or eyes or dark-colored urine.
Brief Description
Indication
Tuberculosis
Administration
Should be taken on an empty stomach. Best taken on an empty stomach 1 hr before or 2 hr after meals. May be taken w/ meals to reduce GI discomfort.
Adult Dose
Oral
Active Tuberculosis Disease
5 mg/kg PO qDay, not to exceed 300 mg qDay
15 mg/kg PO up; not to exceed 900 mg 1-3 times/week
Used in multi-drug regimen containing rifampin (or ribabutin or rifapentin), pyrazinamide, and ethambutol
Latent Tuberculosis Infection
Treatment of latent TB infection greatly reduces the risk that TB infection will progress to acitve disease
>30 kg: 300 mg PO qDay x9 months
Child Dose
Active Tuberculosis Disease
10-15 mg/kg PO qDay; not to exceed 300 mg/day OR
20-30 mg/kg (up to 900 mg) 2 times/week
Used in multi-drug regimen
Latent Tuberculosis Infection
Treatment of latent TB infection greatly reduces the risk that TB infection will progress to acitve disease
10-15 mg/kg PO qDay; not to exceed 300 mg/day
Renal Dose
Renal impairment: Severe: Dose reduction may be needed.
Contraindication
Acute liver disease or history of hepatic damage during INH therapy; hypersensitivity.
Mode of Action
Isoniazid inhibits the synthesis of mycoloic acids in susceptible bacteria which results in loss of acid-fastness and disruption of bacterial cell wall. At therapeutic levels, it is bacteriocidal against actively growing intracellular and extracellular Mycobacterium tuberculosis organisms.
Precaution
Renal or hepatic impairment; convulsive disorders; history of psychosis; patients at risk of neuropathy or pyridoxine deficiency eg, diabetic, alcoholic, malnourished, uraemic, infected with HIV. Careful monitoring of hepatic function is necessary for black and hispanic women. Check hepatic function before and during treatment. Pregnancy and lactation.
Lactation: distributed into milk but safe for nursing infants
Side Effect
>10%
Mild incr LFTs (10-20%),Peripheral neuropathy (dose-related incidence, 10-20% incidence with 10 mg/kg/d)
Loss of appetite,Nausea,Vomiting,Stomach pain,Weakness
1-10%
Dizziness,Slurred speech,Lethargy,Progressive liver damage (increases with age; 2.3% in pts > 50 yo),Hyperreflexia
<1%
Agranulocytosis,Anemia,Megaloblastic anemia,Thrombocytopenia,Systemic lupus erythematosus,Seizure
Potentially Fatal: Hepatotoxicity.
Interaction
Inhibit the hepatic metabolism of antiepileptics (e.g. carbamazepine, ethosuximide, primidone, phenytoin), benzodiazepines (e.g. diazepam, triazolam), chlorzoxazone, theophylline, disulfiram, sometimes leading to increased toxicity. Increased metabolism of enflurane, resulting in potentially nephrotoxic levels of fluoride. Increased concentrations and enhanced effects or toxicity of clofazimine, cycloserine and warfarin. Reduced absorption w/ Al-containing antacids. Increased risk of peripheral neuropathy w/ zalcitabine and stavudine.
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