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Firmagon 80
Radiant Pharmaceuticals Ltd.
Generic: Degarelix
Safety Advices
বাংলা
English
CAUTION
Caution is advised when consuming alcohol with Firmagon 80. Please consult your doctor.
UNSAFE
Firmagon 80 is highly unsafe to use during pregnancy. Seek your doctor's advice as studies on pregnant women and animals have shown significant harmful effects to the developing baby.
CONSULT YOUR DOCTOR
Information regarding the use of Firmagon 80 during breastfeeding is not available. Please consult your doctor.
UNSAFE
Firmagon 80 may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
CONSULT YOUR DOCTOR
There is limited information available on the use of Firmagon 80 in patients with kidney disease. Please consult your doctor.
A cautious use of Firmagon 80 is advised in patients with severe kidney disease.
CAUTION
Firmagon 80 should be used with caution in patients with severe liver disease. Dose adjustment of Firmagon 80 may be needed. Please consult your doctor.
No dose adjustment is recommended for patients with mild to moderate liver disease. Regular monitoring of testosterone levels is advised.
Medicine Overview of Firmagon 80mg Injection
Introduction
Firmagon 80 is used in the treatment of advanced prostate cancer. It works by lowering the amount of testosterone produced in the body and restricts the growth of a cancer cell. Firmagon 80 is given as an injection under the skin only under the supervision of a doctor. Do not try to self inject the medicine as it might enhance the chances of an accident or get injected into the veins. The dose and how often you take it depends on what you are taking it for. Your doctor will decide how much you need to improve your symptoms. You...
... Show moreUses of Firmagon 80
- Prostate cancer
Side effects of Firmagon 80
Common
- Injection site reactions (pain, swelling, redness)
- Weight gain
- Hot flashes
- Increased liver enzymes
- Low sexual desire
- Erectile dysfunction
How to use Firmagon 80
Your doctor or nurse will give you this medicine. Kindly do not self administer.
How Firmagon 80 works
Firmagon 80 lowers the amount of testosterone (a male hormone) produced by the body. This may slow or stop the spread and growth of prostate cancer cells that need testosterone to grow.
What if you forget to take Firmagon 80?
If you miss a dose of Firmagon 80, please consult your doctor.
Quick Tips
- Firmagon 80 helps in the treatment of advanced hormone-dependent prostate cancer.
- It is give by injection under the skin (subcutaneously), usually in the stomach area.
- It may cause dizziness and blurred vision. Do not drive or do anything that requires mental focus until you know how it affects you.
- It may cause hot flashes. Try wearing loose clothing and avoid alcohol, caffeine, and spicy foods.
- Inform your doctor if you are diabetic or have problems with your heart, kidney or liver.
- Your doctor may check the level of prostate specific antigen (PSA) in your blood. This is done to monitor how well Firmagon 80 is working for you. A decrease in PSA levels is usually a sign that your treatment is working.
Brief Description
Indication
Hormone-dependent Advanced Prostate Carcinoma (Stage D)
Administration
Initiation pack contains 2 vials each with 120 mg per vial & 6 mL sterile water for injection diluent
Withdraw 3 mL of sterile water for injection diluent (supplied) & add to 1 of the 2 vials, swirl to mix - keep vial vertical at all times, do not shake
Inject SC in abdomen within 1 hour of reconstitution
Repeat for 2nd injection and use different injection site
Maintenance pack contains 1 vial of 80 mg per vial & 4.2 mL sterile water for injection diluent
Use 4.2 mL to reconstitute, withdraw 4 mL for dose of 80 mg
Adult Dose
Subcutaneous
Advanced prostate cancer
Adult: Loading dose: As 40 mg/mL solution: 240 mg (given as 2 separate injections of 120 mg). Maintenance: As 20 mg/mL solution: 80 mg once every 28 days, starting 28 days after the initial dose. Doses are administered in the abdominal area.
Hepatic Impairment
Mild-to-moderate: Dose adjustment not necessary
Severe: Safety and efficacy not established; use caution
Renal Dose
Renal Impairment
>50 mL/min: Dose adjustment not necessary
<50 mL/min: Use caution
Contraindication
Hypersensitivity. Pregnancy and lactation.
Mode of Action
Degarelix, a synthetic decapeptide, reversibly and competitively binds to gonadotropin-releasing hormone (GnRH) receptors in the anterior pituitary gland, thereby decreasing secretion of luteinising hormone (LH) and follicle stimulating hormone (FSH), and subsequently reducing testicular androgen synthesis.
Precaution
Patient with congenital long QT syndrome, history of or risk factors for QT prolongation (e.g. cardiac failure, electrolyte imbalance) and CV disease; diabetes, risk factors for low BMD. Moderate to severe renal (CrCl <50 mL/min) and severe hepatic impairment.
Lactation: excretion in milk unknown/not recommended
Side Effect
>10%
Hot flashes (26%)
Injection site erythema (17%)
Injection site pain (28%)
Weight gain (11%)
Elevated liver enzymes (10%)
1-10% (selected)
Arthralgia
Back pain
Fatigue
HTN
Injection site induration/swelling
Pregnancy Category Note
Pregnancy Category: X
Lactation: excretion in milk unknown/not recommended
Interaction
Increased risk of QT prolongation with class IA (e.g. disopyramide) or class III (e.g. amiodarone) antiarrhythmics, antipsychotics, methadone and moxifloxacin.
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