12-24 Hours
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Alfavir
Incepta Pharmaceuticals Ltd.
Generic: Tenofovir Alafenamide
Safety Advices
বাংলা
English
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Alfavir. Please consult your doctor.
SAFE IF PRESCRIBED
Alfavir is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
SAFE IF PRESCRIBED
Alfavir is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
UNSAFE
Alfavir may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
CAUTION
Alfavir should be used with caution in patients with kidney disease. Dose adjustment of Alfavir may be needed. Please consult your doctor.
SAFE IF PRESCRIBED
Alfavir is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Alfavir may not be needed in these patients. Please consult your doctor.
Medicine Overview of Alfavir 25mg Tablet
Introduction
Alfavir is used in the treatment of HIV infection and chronic hepatitis B virus (HBV) infection. It prevents the multiplication of virus in human cells. This stops the virus from producing new viruses and clears up your infection. Alfavir should be used in the dose and duration as advised by your doctor. Do not skip any doses and finish the full course of treatment even if you feel better. Take it with food, as this increases the absorption of the medicine into the body. It is important to keep taking them until your doctor tells you it is safe to...
... Show moreUses of Alfavir
- HIV infection
- Chronic hepatitis B virus (HBV) infection
Side effects of Alfavir
Common
- Headache
How to use Alfavir
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Alfavir is to be taken empty stomach.
How Alfavir works
Alfavir is an antiviral medication. It prevents the multiplication of virus in human cells. This stops the virus from producing new viruses and clears up your infection.
What if you forget to take Alfavir?
If you miss a dose of Alfavir, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
- You have been prescribed Tenvir AF 25mg Tablet for the treatment of chronic hepatitis B virus (HBV) infection.
- In combination with other medicines, it is used for the treatment of HIV infections.
- Take it with food, as this increases the absorption of the medicine into the body.
- Tenvir AF 25mg Tablet may cause dizziness or sleepiness. Do not drive or do anything requiring concentration until you know how it affects you.
- You may still develop infections or other illnesses associated with viral infection while taking this medication.
- You can also pass on HIV or HBV to others. Don't share needles or personal items that can have blood or body fluids on them.
- During treatment and for at least six months after stopping this medicine, regular blood tests are needed to monitor your liver function, level of hepatitis B virus and blood cells in your blood.
Brief Description
Indication
Chronic Hepatitis B Infection
Administration
Take with food
Adult Dose
Chronic Hepatitis B Infection
Indicated for treatment of chronic hepatitis B virus (HBV) infection in adults with compensated liver disease
25 mg PO qDay with food
Hepatic impairment
Mild (Child-Pugh A): No dosage adjustment required
Decompensated (Child-Pugh B or C) hepatic impairment: Use not recommended
Renal Dose
Renal impairment
Mild, moderate, or severe: No dosage adjustment required
ESRD (CrCl <15 mL/min): Use not recommended
Contraindication
Hypersensitivity
Mode of Action
Tenofovir alafenamide (AF) is a nucleotide reverse transcriptase inhibitor (NRTI) and a phosphonamidate prodrug of tenofovir Compared with tenofovir disoproxil fumarate (tenofovir DF, Viread), tenofovir AF is a more targeted form of tenofovir that has demonstrated high antiviral efficacy at a dose that is 10 times lower than tenofovir DF, as well as an improved renal and bone safety profile Tenofovir AF as a lipophilic cell-permeant compound enters primary hepatocytes by passive diffusion and by the hepatic uptake transporters OATP1B1 and OATP1B3 and is converted to tenofovir diphosphate Tenofovir diphosphate inhibits HBV replication through incorporation into viral DNA by the...
... Show morePrecaution
Lactic acidosis and severe hepatomegaly with steatosis, including fatalities, reported with nucleoside analogs, including tenofovir disoproxil fumarate in combination with other antiretrovirals; most were reported in women; obesity and prolonged nucleoside exposure may be risks factors Discontinuation of antihepatitis B drugs may result in severe acute exacerbations of hepatitis B Owing to the risk of development of HIV-1 resistance, tenofovir AF alone is not recommended for the treatment of HIV-1 infection; test for HIV-1 before initiating treatment Lactation Unknown if distributed in human breast milk Consider the developmental and health benefits of breastfeeding along with the mother’s clinical need for...
... Show moreSide Effect
1-10%
Headache (9%)
ALT >5 x ULN (8%)
Abdominal pain (7%)
Fatigue (6%)
Cough (6%)
Glycosuria >3+ (5%)
Nausea (5%)
Back pain (5%)
Pregnancy Category Note
There are no human data on use in pregnant women to inform a drug-associated risks of adverse fetal developmental outcome
In animal studies, no adverse developmental effects were observed when tenofovir alafenamide was administered during the period of organogenesis at exposure equal to or 51 times (rats and rabbits, respectively) the tenofovir alafenamide exposure at the recommended daily dose
Interaction
Drugs that induce P-gp result in decreased tenofovir AF absorption and plasma concentrations, which may lead to loss of therapeutic effect (eg, carbamazepine, oxcarbazepine, phenobarbital, phenytoin, rifabutin, rifampin, rifapentine, St John’s wort)
Drugs that inhibit P-gp and BCRP may increase tenofovir AF absorption and plasma concentration.
Coadministration of tenofovir AF with drugs that reduce renal function or compete for active tubular secretion may increase concentrations of tenofovir and other renally eliminated drugs, and this may increase the risk of adverse reactions
Some examples include acyclovir, cidofovir, ganciclovir, valacyclovir, valganciclovir, aminoglycosides, high-dose or long-term NSAD use
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