Parkinson Disease Psychosis
Indicated for treatment of hallucinations and delusions associated with Parkinson disease psychosis
34 mg PO qDay (without titration)
Hepatic impairment
No dosage adjustment recommended
Renal Dose
Renal impairment
Mild-to-moderate (CrCl ?30 mL/min): No dosage adjustment required
Severe (CrCl <30 mL/min) or end stage renal disease: Use with caution
Contraindication
Documented hypersensitivity reaction to drug or components; rash, urticaria, and reactions consistent with angioedema (e.g., tongue swelling, circumoral edema, throat tightness, and dyspnea)
Mode of Action
Selective serotonin inverse agonist and antagonist activity preferentially targeting 5-HT2A receptors believed to play an important role in psychosis
Precaution
Antipsychotic drugs increase the all-cause risk of death in elderly patients with dementia-related psychosis
Pimavanserin is a substrate of CYP3A4; strong CYP3A4 inhibitor or inducers affect systemic exposure
Pregnancy
There are no data for use in pregnant women that would allow assessment of the drug-associated risk of major congenital malformations or miscarriage
In animal reproduction studies, no adverse developmental effects were seen when pimavan...
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The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts.