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Doloran PR
Nevian Lifescience PLC
Generic: Tramadol Hydrochloride
Safety Advices
বাংলা
English
UNSAFE
It is unsafe to consume alcohol with Doloran PR.
CONSULT YOUR DOCTOR
Doloran PR may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
SAFE IF PRESCRIBED
Doloran PR is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
Consult a doctor immediately if the baby shows signs of increased sleepiness (more than usual), difficulty breastfeeding, breathing problems, or limpness.
UNSAFE
Doloran PR may cause side effects which could affect your ability to drive.
Doloran PR may cause side effects such as drowsiness and blurred vision. If this happens, do not drive.
CAUTION
Doloran PR should be used with caution in patients with kidney disease. Dose adjustment of Doloran PR may be needed. Please consult your doctor.
CAUTION
Doloran PR should be used with caution in patients with liver disease. Dose adjustment of Doloran PR may be needed. Please consult your doctor.
Medicine Overview of Doloran PR 100mg Tablet
Introduction
Doloran PR is a pain relieving medicine. It is used to manage persistent, moderate to severe chronic pain that requires continuous, around-the-clock treatment. Doloran PR is generally administered by a healthcare professional. You should not self-administer this medicine at home. The dose and duration will depend on what you are taking it for and how well it helps your symptoms. The most common side effects of this medicine include injection site reactions (such as pain, redness, and swelling), headache, drowsiness, fatigue, vomiting, constipation, dry mouth, and sweating. If any of these side effects persist or get worse, you should let...
... Show moreUses of Doloran PR
- Moderate to severe pain
Side effects of Doloran PR
Common
- Dizziness
- Sleepiness
- Vomiting
- Nausea
- Constipation
How to use Doloran PR
Your doctor or nurse will give you this medicine. Kindly do not self administer.
How Doloran PR works
Doloran PR is an opioid analgesic (pain reliever) which works by blocking transmission of pain signals to the brain to lower pain perception.
What if you forget to take Doloran PR?
If you miss a dose of Doloran PR, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
- Use only for severe acute pain for not more than 5 days. Prolonged use may result in physical and psychological dependence even at recommended dosages. Avoid driving or using machinery if you feel dizzy after taking Doloran PR. It is better to take with food to avoid an upset stomach. Your doctor may adjust your dose if you have liver or kidney disease.
Brief Description
Indication
Moderate to severe pain, Postoperative pain
Administration
May be taken with or without food.
Adult Dose
Oral Moderate to severe pain Adult: Immediate release Chronic pain: 25 mg PO every morning initially; increased by 25-50 mg/day every 3 days up to 50-100 mg PO q4-6hr PRN; not to exceed 400 mg/day Acute pain: 50-100 mg PO q4-6hr PRN; not to exceed 400 mg/day Extended release 100 mg PO once daily initially; increased by 100 mg/day every 5 days; not to exceed 300 mg/day Parenteral Moderate to severe pain Adult: IM/IV: 50-100 mg 4-6 hrly over 2-3 min. Postoperative pain Adult: Initially, 100 mg followed by 50 mg every 10-20 min if necessary, to a total of...
... Show moreChild Dose
Moderate-to-Severe Pain
Immediate release
17 years (acute): 50-100 mg PO q4-6hr PRN; not to exceed 400 mg/day
>17 years (chronic): 25 mg PO every morning initially; increased by 25-50 mg/day every 3 days as separate doses up to 50-100 mg PO q4-6hr PRN; not to exceed 400 mg/day
Extended release
<18 years: Safety and efficacy not established
Renal Dose
Renal impairment:
CrCl (ml/min) Dosage Recommendation
10-30 Increase dosing interval to 12 hrly.
<10 Contraindicated.
Contraindication
Suicidal patients, acute alcoholism; head injuries; raised intracranial pressure; severe renal impairment; lactation.
Mode of Action
Tramadol inhibits reuptake of norepinephrine, serotonin and enhances serotonin release. It alters perception and response to pain by binding to mu-opiate receptors in the CNS.
Precaution
Patients who suffer from emotional disturbance or depression, history of epilepsy or risk of seizure, head injury, increased intracranial pressure. Renal and hepatic impairment. Elderly. Pregnancy and lactation. Patient Counselling May impair ability to drive or operate machinery. Monitoring Parameters Monitor pain relief, resp rate, BP, pulse rate; signs of tolerance, abuse, or suicidal ideation.
Lactation: Drug excreted at high concentration in breast milk; not recommended
Side Effect
>10%
Constipation (24-46%),Nausea (24-40%),Dizziness (10-33%),Vertigo (26-33%),Headache (18-32%),Somnolence (7-25%),Vomiting (9-17%),Agitation (7-14%),Anxiety (7-14%),Emotional lability (7-14%),Euphoria (7-14%),Hallucinations (7-14%),Nervousness (7-14%),Spasticity (7-14%),Dyspepsia (5-13%),Asthenia (6-12%),Pruritus (8-11%)
1-10%
Diarrhea (5-10%),Dry mouth (5-10%),Sweating (6-9%),Hypertonia (1-5%),Malaise (1-5%),Menopausal symptoms (1-5%),Rash (1-5%),Urinary frequency (1-5%),Urinary retention (1-5%),Vasodilation (1-5%),Visual disturbance (1-5%)
<1%
Abnormal gait,Amnesia,Cognitive dysfunction,Depression,Difficulty in concentration,Dysphoria,Dysuria,Fatigue,Hallucinations,Menstrual disorder,Motor system weakness,Orthostatic hypotension,Paresthesia,Seizures,Suicidal tendencies,Syncope,Tachycardia,Tremor
Frequency Not Defined
Abnormal electrocardiogram (ECG),Angioedema,Bronchospasm,Flushing,Hypertension,Hypotension,Myocardial ischemia,Palpitation,Urticaria,Withdrawal syndrome
Potentially Fatal: Respiratory depression.
Interaction
Increased risk of convulsions or serotonin syndrome w/ SSRI, serotonin-norepinephrine reuptake inhibitors (SNRI), TCA and other seizure threshold lowering drugs (e.g. bupropion, mirtazapine, tetrahydrocannabinol). Decreased serum concentrations w/ carbamazepine. May potentiate the anti-depressant effect of norepinephrine, 5-HT agonists or lithium. Increased INR and ecchymoses w/ coumarin derivatives (e.g. warfarin).
Potentially Fatal: Increased risk of seizure and serotonin syndrome w/ MAOIs.
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