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Prosulf
Radiant Pharmaceuticals Ltd.
Generic: Protamine Sulfate
Safety Advices
বাংলা
English
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Prosulf. Please consult your doctor.
CONSULT YOUR DOCTOR
Prosulf may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
SAFE IF PRESCRIBED
Prosulf is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
SAFE
Prosulf does not usually affect your ability to drive.
SAFE IF PRESCRIBED
Prosulf is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Prosulf may not be needed in these patients. Please consult your doctor.
SAFE IF PRESCRIBED
Prosulf is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Prosulf may not be needed in these patients. Please consult your doctor.
Medicine Overview of Prosulf 10mg/ml Injection
Introduction
Prosulf is a medicine which is used in the treatment of heparin overdose. It neutralizes the anti-blood clotting effect of heparin and stops excessive bleeding. Prosulf is generally administered by a healthcare professional. You should not self administer this medicine. Inform your doctor if you have undergone heart surgery, have had a vasectomy, have diabetes, have received protamine insulin, or allergic to fish. Using of Prosulf can cause few side effects such as decreasing your blood pressure, slow heart rate, or reactions at the site of injection. It is important to monitor the clotting levels if you are receiving multiple...
... Show moreUses of Prosulf
- Heparin overdose
Side effects of Prosulf
Common
- Hypersensitivity
- Decreased blood pressure
- Slow heart rate
How to use Prosulf
Your doctor or nurse will give you this medicine. Kindly do not self administer.
How Prosulf works
Prosulf is used to counteract the anticoagulant effect of heparin and is used to stop bleeding in patients caused by heparin.
What if you forget to take Prosulf?
If you miss a dose of Prosulf, please consult your doctor.
Brief Description
Indication
Heparin Neutralization, Dalteparin or Tinzaparin Overdose, Enoxaparin Overdose
Administration
IV Preparation
Reconstitute with 5 mL sterile water
Resulting solution equals 10 mg/mL
IV Administration
Inject without further dilution over 1-3 min; maximum of 50 mg in any 10 min period
For IV use only
Administer slow IVP (50 mg over 10 min)
Rapid IV infusion causes hypotension
Adult Dose
Heparin Neutralization 1-1.5 mg per 100 USP units of heparin; not to exceed 50 mg Monitor APTT 5-15 min after dose then in 2-8 hr In accidental overdoses of heparin, consider t1/2 heparin 60-90 min In setting without bleeding complications, consider observation, rather than reversal of anticoagulation with protamine (avoids ADR's) Complex of protamine and heparin may degrade over time requiring further doses Dalteparin or Tinzaparin Overdose 1 mg protamine for 100 units dalteparin or tinzaparin; if PTT prolonged 4hr after protamine overdose administer 0.5 mg per 100 units of dalteparin or tinzaparin Enoxaparin Overdose 1 mg per mg enoxaparin...
... Show moreContraindication
Hypersensitivity
Mode of Action
Protamine sulfate is prepared from the sperm or mature testes of salmon or related species and is composed of arginine, proline, serine and valine. It combines w/ strongly acidic heparin to form a stable complex, neutralising the anticoagulant activity of both drugs.
Precaution
Patient at risk of developing hypersensitivity to protamine (e.g. previous history of procedures such as coronary angioplasty or cardiopulmonary bypass surgery where protamine is frequently used, diabetics using protamine insulin, allergy to fish, vasectomised or infertile males who may have antibodies to protamine). Pregnancy and lactation.
Protamine sulfate can cause severe hypotension, cardiovascular collapse, noncardiogenic pulmonary edema, catastrophic pulmonary vasoconstriction, and pulmonary hypertension
Side Effect
Frequency Not Defined
Anaphylaxis
Hypotension
N/V
Decreased O2 consumption
Flushing
Pulmonary hypertension
Uncontrollable bleeding
Circulatory collapse
Pulmonary edema
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