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Clopixol Acuphase
Lundbeck Pharmaceuticals Ltd
Generic: Zuclopenthixol
Safety Advices
বাংলা
English
UNSAFE
Clopixol Acuphase may cause excessive drowsiness with alcohol.
CONSULT YOUR DOCTOR
Clopixol Acuphase may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
CONSULT YOUR DOCTOR
Clopixol Acuphase is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
UNSAFE
Clopixol Acuphase may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
CAUTION
Clopixol Acuphase should be used with caution in patients with kidney disease. Dose adjustment of Clopixol Acuphase may be needed. Please consult your doctor.
CAUTION
Clopixol Acuphase should be used with caution in patients with liver disease. Dose adjustment of Clopixol Acuphase may be needed. Please consult your doctor.
Medicine Overview of Clopixol Acuphase 50mg/ml Injection
Introduction
Clopixol Acuphase is a prescription medicine used in the treatment of schizophrenia and anxiety disorder. It alters the thoughts and elevates the mood, improving the person’s ability to think, feel and behave. Clopixol Acuphase is given as an injection under the supervision of a healthcare professional and should not be self administered. Take it at the same time each day as this helps to maintain a consistent level of medicine in the body. Take this medicine in the dose and duration as advised by your doctor and if you have missed a dose, take it as soon as you remember...
... Show moreUses of Clopixol Acuphase
- Schizophrenia
- Anxiety
Side effects of Clopixol Acuphase
Common
- Abnormality of voluntary movements
- Constipation
- Dryness in mouth
- Increased prolactin level in blood
- Orthostatic hypotension (sudden lowering of blood pressure on standing)
- Sleepiness
- Tremor
- Urinary retention
- Weight gain
How to use Clopixol Acuphase
Your doctor or nurse will give you this medicine. Kindly do not self administer.
How Clopixol Acuphase works
Clopixol Acuphase is a typical antipsychotic. It works by blocking the action of dopamine, a chemical messenger in the brain that affects thoughts and mood.
Quick Tips
- Clopixol Acuphase is administered into the muscle of the buttock or thigh.
- Use caution while driving or doing anything that requires concentration as Clopixol Acuphase can cause dizziness and sleepiness.
- Avoid drinking alcohol while taking this medicine because it can make drowsiness worse.
- It may affect how your body regulates your temperature. Avoid situations that can result in your overheating or getting dehydrated.
- It may increase your weight, blood sugar and cholesterol. Eat healthy, exercise regularly and monitor your blood levels regularly.
- Inform your doctor if you experience any swelling, particularly of the face, lips, jaw and tongue and trouble breathing while taking this medicine.
Brief Description
Indication
Schizophrenia, Psychoses, Bipolar mania
Administration
May be taken with or without food.
Adult Dose
Oral Psychoses Adult: Initially, 20-30 mg daily in divided doses. Usual maintenance dose: 20-50 mg daily. Up to 150 mg daily for severe or resistant cases. Intramuscular Psychoses Adult: As acetate: 50-150 mg via deep IM inj. May repeat, if needed, after 2-3 days. An additional dose 1-2 days after the 1st dose may be required in some patients. Not >4 inj should be given in a max course of 2 wk and total dose should not exceed 400 mg. Maintenance: May start oral zuclopenthixol HCl 2-3 days after the last acetate inj or begin IM inj of decanoate with...
... Show moreRenal Dose
Renal impairment: Dose reduction may be needed.
Contraindication
Hypersensitivity. Comatose states e.g. alcohol, barbiturate and opiate intoxications; porphyria. children.
Mode of Action
Zuclopenthixol has high affinity for D1 and D2 receptors and ?-adrenoreceptors. It also has slight antihistamine properties and blocks serotonergic properties.
Precaution
Hepatic and renal impairment, heart disease, recent acute MI, arrhythmias, significant bradycardia (<50 beats/min), severe respiratory disease, epilepsy (and conditions at risk of epilepsy, e.g. alcohol withdrawal or brain damage), Parkinson's disease, acute angle glaucoma, prostatic hypertrophy, hypothyroidism, hyperthyroidism, myasthenia gravis, phaeochromocytoma. Patients at risk of stroke and QT interval prolongation. Avoid abrupt withdrawal. Ability to drive a car or operate machinery may be impaired.
Side Effect
Drowsiness, blurred vision, tachycardia, nausea, dizziness, headache, excitement, postural hypotension, hyperprolactinaemia, sexual dysfunction, ECG changes (prolongation of QT interval and T wave changes), hyperthermia. Extrapyramidal symptoms may occur, especially during the early phase of treatment; urinary frequency or incontinence; tardive dyskinesia.
Potentially Fatal: Neuroleptic malignant syndrome, blood dyscrasias.
Interaction
Zuclopenthixol may enhance the sedative effects of alcohol and the effects of barbiturates and other CNS depressants. Zuclopenthixol reduces the antihypertensive effect of guanethidine. Concomitant use of metoclopramide and piperazine with zuclopenthixol increases the risk of extrapyramidal symptoms. Increased risk of severe neurotoxicity with lithium and sibutramine. Increased anticholinergic side effects with drugs with anticholinergic properties.
Potentially Fatal: Antagonises effect of apomorphine, levodopa and other dopamine agonists. Increased risk of blood dyscrasias with clozapine. Increased risk of arrhythmias with dugs that prolong QT interval e.g. class Ia and III antiarrhythmics, erythromycin or cause electrolyte disturbances e.g. thiazide diuretics.
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