>10%
Hematuria (11% vs 10% in placebo-treated),Asthenia (13% vs. 14% placebo),Hepatitis exacerbation (25%)
1-10%
Nausea (5%),Flatulence (4%),Diarrhea (3%)Dyspepsia (3%),Headache (9%),Rash (1-10%),Pruritus (1-10%),Dyspepsia (5-9%),Cough (6-8%),Rhinitis (5%)
Increased AST/ALT,Abnormal liver function,Renal failure,Renal insufficiency,Increased serum Cr (2-3%),Hypophosphatemia
Potentially Fatal: Lactic acidosis, severe hepatomegaly with steatosis, hepatotoxicity, nephrotoxicity.