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Xeroder IV
Beacon Pharmaceuticals PLC
Generic: Fluconazole 0.2% IV
Safety Advices
বাংলা
English
CAUTION
Caution is advised when consuming alcohol with Xeroder IV. Please consult your doctor.
CONSULT YOUR DOCTOR
Xeroder IV is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
SAFE IF PRESCRIBED
Xeroder IV is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.
UNSAFE
Xeroder IV may cause side effects which could affect your ability to drive.
Xeroder IV may cause dizziness or seizures. This may affect your ability to drive.
UNSAFE
Xeroder IV is probably unsafe to use in patients with kidney disease and should be avoided. Please consult your doctor.
Caution to be advised in patients with impaired renal function.
CAUTION
Xeroder IV should be used with caution in patients with liver disease. Dose adjustment of Xeroder IV may be needed. Please consult your doctor.
Medicine Overview of Xeroder IV 0.20% Infusion
Introduction
Xeroder IV belongs to a group of medicines called antifungals. It works by stopping the growth of fungus and is used to treat infections of the mouth, throat, vagina and other parts of the body including fingernails and toenails. It kills fungi by destroying the fungal cell membrane. Xeroder IV is an injectable drug and given as a drip by a healthcare professional. Do not self administered the injection. Your doctor or nurse will teach you the correct way of injecting it. To get the most benefit, take this medicine at evenly spaced times and continue using it until your...
... Show moreUses of Xeroder IV
- Fungal infections
Side effects of Xeroder IV
Common
- Headache
- Nausea
- Rash
- Vomiting
How to use Xeroder IV
Your doctor or nurse will give you this medicine. Kindly do not self administer.
How Xeroder IV works
Xeroder IV is an antifungal medication. It kills and stops the growth of the fungi by destroying its cell membrane, thereby treating your skin infection.
What if you forget to take Xeroder IV?
If you miss a dose of Xeroder IV, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
- Your doctor has prescribed Xeroder IV to cure your infection and improve symptoms.
- It is given as a drip under the supervision of a medical professional.
- Do not skip any doses and finish the full course of treatment even if you feel better.
- Inform your doctor if you notice shortness of breath, swelling in face and throat, and drop-in blood pressure.
- Use a reliable method of contraception to prevent pregnancy while taking this medicine.
- Your doctor may check your liver function before starting treatment and regularly thereafter. Inform your doctor if you notice yellowing of eyes or skin, dark urine, or stomach pain.
Brief Description
Indication
Systemic fungal infections, Cryptococcal meningitis, Disseminated candidiasis, Fungal UTIs, Oral or vaginal thrush
Adult Dose
Intravenous The daily dose of Fluconazole Injection, for the treatment of infections should be based on the infecting organism and the patient’s response to therapy. Treatment should be continued until clinical parameters or laboratory tests indicate that active fungal infection has subsided. An inadequate period of treatment may lead to recurrence of active infection. Patients with AIDS and cryptococcal meningitis or recurrent oropharyngeal candidiasis usually require maintenance therapy to prevent relapse. Oropharyngeal candidiasis: The recommended dosage 200 mg on the first day, followed by 100 mg once daily. Treatment should be continued for at least 2 weeks to decrease the...
... Show moreChild Dose
Intravenous Oropharyngeal candidiasis: The recommended dosage of Fluconazole Injection, in children is 6 mg/kg on the first day, followed by 3 mg/kg once daily. Treatment should be administered for at least 2 weeks to decrease the likelihood of relapse. Esophageal candidiasis: The recommended dosage is 6 mg/kg on the first day, followed by 3 mg/kg once daily. Doses up to 12 mg/kg/day may be used based on medical judgment of the patient’s response to therapy. Patients with esophageal candidiasis should be treated for a minimum of 3 weeks and for at least 2 weeks following the resolution of symptoms. Systemic...
... Show moreRenal Dose
Renal impairment: Haemodialysis patients: Usual dose given after each session.
CrCl (ml/min) Dosage Recommendation
50 Usual dose.
Contraindication
- Known hypersensitivity
- Advanced liver disease
Mode of Action
Fluconazole decreases ergosterol synthesis by interfering w/ cytochrome P450 activity, thus inhibiting cell membrane formation of susceptible fungi including B. dermatitidis, Candida spp., C. immitis, C. neoformans, Epidermophyton spp., H. capsulatum, Micosporum spp., Trichophyton spp.
Precaution
Renal or hepatic impairment. May prolong QT interval. Pregnancy, lactation. CDC guidelines recommend only using topical antifungal products to treat pregnant women with vulvovaginal yeast infections, including for longer periods than usual if these infections persist or recur.
Lactation
Enters breast milk; use caution
Side Effect
>10%
Headache (2-13%)
1-10%
Nausea (2-7%),Abdominal pain (2-6%),Diarrhea (2-3%),Rash (2%),Vomiting (2-5%)
Frequency Not Defined
QT prolongation,Torsades de pointes,Alopecia,Anaphylactic reactions,Angioedema,Cholestasis,Dizziness,Dyspnea,Hepatic failure,Hepatitis,Hypertriglyceridemia,Hypokalemia,Increased alkaline phosphatase,Increased ALT/AST,Jaundice,Leukopenia,Pallor,Seizures,Stevens-Johnson syndrome,Taste perversion,Thrombocytopenia,Toxic epidermal necrolysis
Potentially Fatal: Hepatotoxicity; rarely anaphylaxis; Stevens-Johnson syndrome.
Pregnancy Category Note
Pregnancy Single maternal PO dose of 150 mg for vaginal candidiasis Results of a Danish study concludes there is a possible increased risk of miscarriage; women who are pregnant or actively trying to get pregnant should ask their physician about alternative treatments Spontaneous abortion between 7 and 22 weeks' gestation occurred significantly more often in women exposed to oral fluconazole than unexposed pregnancies (4.43% vs. 4.25%; hazard ratio, 1.48); fluconazole was also compared with intravaginal azole antifungals to account for confounding by candidiasis, again, the oral drug was associated with significantly increased risk for spontaneous abortion - JAMA. 2016;315(1):58-67 CDC...
... Show moreInteraction
May increase plasma concentrations of oral hypoglycaemics (e.g. tolbutamide, glyburide, glipizide), phenytoin, theophylline, tofacitinib, rifabutin. May increase prothrombin time w/ anticoagulants. May cause significant increase in ciclosporin levels in renal transplant patients w/ or w/o renal impairment. Rifampicin reduces fluconazole levels. May increase risk of nephrotoxicity w/ tacrolimus. May increase the effect of short-acting benzodiazepines (e.g. midazolam).
Potentially Fatal: Increased risk of cardiac arrhythmias or QT prolongation w/ terfenadine, cisapride, astemizole, pimozide, quinidine, halofantrine and erythromycin.
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