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Zeffix
Glaxo SmithKline Pharmaceuticals Ltd
Generic: Lamivudine
Safety Advices
বাংলা
English
CAUTION
Caution is advised when consuming alcohol with Zeffix. Please consult your doctor.
CONSULT YOUR DOCTOR
Zeffix may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
SAFE IF PRESCRIBED
Zeffix is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
SAFE
Zeffix does not usually affect your ability to drive.
CAUTION
Zeffix should be used with caution in patients with kidney disease. Dose adjustment of Zeffix may be needed. Please consult your doctor.
SAFE IF PRESCRIBED
Zeffix is safe to use in patients with liver disease. No dose adjustment of Zeffix is recommended.
Medicine Overview of Zeffix 100mg Tablet
Introduction
Zeffix is used in the treatment of HIV infection and chronic hepatitis B virus (HBV) infection. It prevents the multiplication of virus in human cells. This stops the virus from producing new viruses and clears up your infection. Zeffix is not a cure for HIV or AIDS and only helps to decrease the amount of HIV in your body. This helps to lower your risk of getting HIV-related complications and improves your lifespan. It is prescribed in combination with other HIV medicines. Your doctor will recommend the best medicines for you and will decide the doses that you need. Follow...
... Show moreUses of Zeffix
- HIV infection
- Chronic hepatitis B virus (HBV) infection
Side effects of Zeffix
Common
- Headache
- Runny nose
- Nausea
- Fever
- Diarrhea
How to use Zeffix
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Zeffix may be taken with or without food, but it is better to take it at a fixed time.
How Zeffix works
Zeffix is an antiviral medication. It prevents the multiplication of virus in human cells. This stops the virus from producing new viruses and clears up your infection.
What if you forget to take Zeffix?
If you miss a dose of Zeffix, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
- You have been prescribed Lamivir HBV Tablet for the treatment of chronic hepatitis B virus (HBV) infection.
- In combination with other medicines, it is used for the treatment of HIV infections.
- Take it with food, as this increases the absorption of the medicine into the body.
- Lamivir HBV Tablet may cause dizziness or sleepiness. Do not drive or do anything requiring concentration until you know how it affects you.
- You may still develop infections or other illnesses associated with viral infection while taking this medication.
- You can also pass on HIV or HBV to others. Don't share needles or personal items that can have blood or body fluids on them.
- During treatment and for at least six months after stopping this medicine, regular blood tests are needed to monitor your liver function, level of hepatitis B virus and blood cells in your blood.
Brief Description
Indication
HIV infection, Chronic hepatitis B
Administration
May be taken with or without food.
Adult Dose
Oral
HIV infection
Adult: 150 mg bid or 300 mg once daily, in combination with other antiretrovirals.
Chronic hepatitis B
Adult: 100 mg once daily. For patients with concomitant HIV infection: 300 mg once daily or in 2 divided doses.
Child Dose
Oral
HIV infection
Child: 3 mth-12 yr: 4 mg/kg bid. Max: 300 mg/day.
Chronic hepatitis B
Child: >2 yr: 3 mg/kg once daily. Max: 100 mg/day.
Renal Dose
Oral HIV infection Renal impairment: Dialysis patients: Not recommended. CrCl (ml/min) 30-49 1st dose 150 mg, then 150 mg once daily. 15-29 1st dose 150 mg, then 100 mg once daily. 5-14 1st dose 150 mg, then 50 mg once daily. <5 1st dose 50 mg, then 25 mg once daily. Chronic hepatitis B Renal impairment: Haemodialysis patients: Dose adjustment in accordance with CrCl. Peritoneal dialysis patients: Not recommended. CrCl (ml/min) 30-49 1st dose 100 mg, then 50 mg once daily. 15-29 1st dose 100 mg, then 25 mg once daily. 5-14 1st dose 35 mg, then 15 mg once...
... Show moreContraindication
Hypersensitivity. Lactation.
Mode of Action
Lamivudine, a nucleoside analogue, is phosphorylated in the body to the active triphosphate form. In the active form, it inhibits hepatitis B virus polymerase and HIV reverse transcriptase enzymes.
Precaution
Discontinue use if there is rapid increase in aminotransferase levels, progressive hepatomegaly, or metabolic or lactic acidosis of unknown origin. Discontinue use if clinical signs, symptoms or lab abnormalities suggestive of pancreatitis develop. Hepatomegaly or other risk factors for hepatic impairment. Monitor hepatic function in chronic hepatitis B patients. Exclude HIV infection prior to hepatitis B therapy. Renal impairment. Pregnancy.
Side Effect
>10%
Cough,Diarrhea,Fatigue & malaise,Fever (peds),Headache,Musculoskeletal pain,Nausea,Nervous system neuropathy,Pancreatitis,Peripheral neuropathy,Nasal S/S,Vomiting
1-10%
Abdominal cramps, abdominal pain,Anorexia &/or decr appetite,Arthralgia,Chills,Depression,Dizziness,Dyspepsia,Insomnia,Myalgia,Rash,Thrombocytopenia,Creatine phosphokinase increased
Frequency Not Defined
Body fat redistribution,Elevated amylase,Neutropenia,Hepatitis B exacerbation
Potentially Fatal: Lactic acidosis associated with severe hepatomegaly and hepatic steatosis.
Interaction
Renal excretion may be inhibited by high doses of trimethoprim (co-trimoxazole). May antagonise the antiviral action of zalcitabine.
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