Introduction
Orobac 200 is an antibiotic medicine used to treat a variety of bacterial infections. It is effective in infections of the respiratory tract (eg. pneumonia), urinary tract, ear, nasal sinus, throat, and some sexually transmitted diseases.
Orobac 200 should be taken with food to avoid an upset stomach. You should take it regularly at evenly spaced intervals as per the schedule prescribed by your doctor. Taking it at the same time every day will help you to remember to take it. The dose will depend on what you are being treated for, but you should always complete a full course of this antibiotic as prescribed by your doctor. Do not stop taking it until you have finished, even when you feel better. If you stop taking it early, some bacteria may survive and the infection may come back. It will not work for viral infections such as flu or the common cold. Using any antibiotic when you do not need it can make it less effective for future infections.
The most common side effects of this medicine include headache, vomiting, nausea, indigestion, stomach pain, and diarrhea. These are usually mild but let your doctor know if they bother you or last more than a few days.
Before using it, you should tell your doctor if you are allergic to any antibiotics or have any kidney or liver problems. You should also let your healthcare team know all other medicines you are taking as they may affect, or be affected by, this medicine. Pregnant and breastfeeding mothers should consult their doctor before using it.
Side effects of Zostum-O Tablet
Common
- Nausea
- Indigestion
- Stomach pain
- Diarrhea
How to use Zostum-O Tablet
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Orobac 200 is to be taken with food.
How Zostum-O Tablet works
Orobac 200 is an antibiotic. It kills the bacteria by preventing them from forming the bacterial protective covering (cell wall) which is needed for them to survive.
What if you forget to take Zostum-O Tablet?
If you miss a dose of Orobac 200, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Indication
Pharyngitis, Community-acquired pneumonia, Susceptible infections, Tonsillitis, Soft tissue infections, Respiratory tract infections, Acute Exacerbations of Chronic bronchitis
Administration
Should be taken with food.
Adult Dose
Oral
Community-acquired pneumonia
Adult: 400 mg bid for 14 days.
Acute bacterial exacerbation of chronic bronchitis
Adult: 400 mg bid for 10 days.
Pharyngitis ; Tonsillitis; Uncomplicated skin and skin structure infections
Adult: 200 mg bid for 10 days.
Child Dose
<12 years old: Safety & efficacy not established
>12 years old: As in adults
Renal Dose
Renal impairment:
CrCl (ml/min)
30-49 Maximum: 200 mg bid
<30 Maximum: 200 mg once daily
Contraindication
Hypersensitivity to Cefditoren, other cephalosporins; or milk proteins. Carnitine deficiency.
Mode of Action
Cefditoren is a third generation cephalosporin used for treatment of susceptible infections caused by gram-positive and gram-negative bacteria. It inhibits bacterial cell wall synthesis by binding to one or more of the penicillin-binding proteins (PBPs).
Precaution
Pregnancy and lactation. Patients with penicillin allergy. Avoid prolonged use as pivalate-containing compounds may cause carnitine deficiency over time; greater risk of carnitine deficiency in patients with renal impairment or decreased muscle mass. May decrease prothrombin activity especially in patients with renal or hepatic impairment, poor nutritional status, prolonged antibiotic treatment or patients previously stabilised on anticoagulant therapy. Long term use may result in development of drug-resistant bacteria, or superinfection including Clostridium difficile-associated diarrhoea and pseudomembranous colitis.
Lactation: excretion in milk unknown; use with caution
Side Effect
>10%
Diarrhea (11-15%)
1-10%
Nausea (4-6%),Headache (2-3%),Abdominal pain (2%),Dyspepsia (1-2%),Vomiting (1%)
<1%
Bacterial/fungal superinfection,C. difficile colitis,Hypersensitivity,Increased bleeding time,Stevens-Johnson syndrome,Vaginal moniliasis
Potentially Fatal: Hypersensitivity, anaphylaxis, Stevens-Johnson syndrome, toxic epidermal necrolysis.
Pregnancy Category Note
Pregnancy Category: B
Lactation: excretion in milk unknown; use with caution
Interaction
Reduced oral bioavailability when coadministered with antacids or H2-receptor antagonists. Probenecid may increase plasma concentration and prolong half-life of Cefditoren. May enhance anticoagulant effect of vitamin K antagonists (e.g. warfarin).