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Safety Advices
বাংলা
English
UNSAFE
It is unsafe to consume alcohol with Melleril.
CONSULT YOUR DOCTOR
Melleril may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
CONSULT YOUR DOCTOR
Melleril is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
UNSAFE
Melleril may cause side effects which could affect your ability to drive.
As Melleril may impair your thinking or reactions. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy and this may affect your ability to drive.
CONSULT YOUR DOCTOR
There is limited information available on the use of Melleril in patients with kidney disease. Please consult your doctor.
CONSULT YOUR DOCTOR
There is limited information available on the use of Melleril in patients with liver disease. Please consult your doctor.
Medicine Overview of Melleril 25mg Tablet
Introduction
Melleril is a prescription medicine used in the treatment of schizophrenia. It alters the thoughts and elevates the mood, improving the person’s ability to think, feel and behave. Melleril should be taken with food, preferably at the same time each day. Take it at the same time each day as this helps to maintain a consistent level of medicine in the body. Take this medicine in the dose and duration as advised by your doctor and if you have missed a dose, take it as soon as you remember it. Do not skip any doses and finish the full course...
... Show moreUses of Melleril
- Schizophrenia
Side effects of Melleril
Common
- Orthostatic hypotension (sudden lowering of blood pressure on standing)
- Sleepiness
- Dryness in mouth
- Abnormality of voluntary movements
- Weight gain
- Increased prolactin level in blood
- Urinary retention
- Constipation
- Muscle stiffness
- Tremor
How to use Melleril
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Melleril is to be taken with food.
How Melleril works
Melleril is a typical antipsychotic. It works by blocking the action of dopamine, a chemical messenger in the brain that affects thoughts and mood.
Quick Tips
- Melleril should be taken with food, preferably at the same time every day.
- It may increase your weight, blood sugar and cholesterol. Eat healthy, exercise regularly and monitor your blood levels regularly.
- Use caution while driving or doing anything that requires concentration as Melleril can cause dizziness and sleepiness.
- Get regular eye examinations while taking this medicine, as it can sometimes cause eye problems.
- Get regular blood tests to monitor the levels of electrolytes (salts such as potassium and magnesium) in your blood as suggested by your doctor.
- Regularly get your heart function monitored as suggested by your doctor.
- Inform your doctor if you experience any abnormal movements, particularly of the face, lips, jaw and tongue, while taking this medicine.
Brief Description
Indication
Depression, Schizophrenia
Administration
Should be taken with food.
Adult Dose
Oral
Schizophrenia
Adult: Initially, 50-100 mg tid, gradually increased if necessary in increments of not more than 100 mg wkly. Usual daily dose: 200-800 mg in 2-4 divided doses. Max: 800 mg daily.
Depressive Disorders
Adult: Initially, 25 mg tid, titrated to 20-200 mg daily.
Hepatic impairment: Lower initial doses and more gradual dosage increase.
Child Dose
Oral
Schizophrenia
Child: 2-12 yr: Initially, 0.5 mg/kg daily in divided doses, increased gradually until optimum effect obtained. Max: 3 mg/kg daily.
>12 years: Initial 50-100 mg PO q8hr; titrate to 200-800 mg/day PO divided q6-12hr
Renal Dose
Renal impairment: Lower initial doses and more gradual dosage increase.
Contraindication
Hypersensitivity to phenothiazines, comatose states, pre-exisitng CNS depression, severe CVS disorders, uncorrected hypokalaemia or any electrolyte imbalance, known or suspected QT prolongation, history of ventricular arrhythmias including torsades de pointes and porphyria. Bone-marrow suppression, phaeochromocytoma, or prolactin-dependent tumours, angle-closure glaucoma, history of jaundice, parkinsonism, DM, hypothyroidism, myasthenia gravis, paralytic ileus, prostatic hyperplasia, or urinary retention. Patients with reduced activity of cytochrome P450 isoenzyme CYP2D6.
Mode of Action
Thioridazine, a phenothiazine antipsychotic, exhibits strong beta-adrenergic blocking effects and depresses the release of hypothalamic and hypophyseal hormones by blocking postsynaptic mesolimbic, dopaminergic receptors in the brain.
Precaution
Patient w/ severe CV disease, narrow-angle glaucoma, Parkinson's disease, seizure disorder. Avoid abrupt withdrawal. Hepatic and renal impairment. Elderly w/ dementia-related psychosis. Pregnancy and lactation. Patient Counselling May impair ability to drive or operate machinery. Monitoring Parameters Determine ECG and serum K concentrations at baseline and periodically thereafter.
Side Effect
Tardive dyskinesia; leucopenia, neutropenia, agranulocytosis; drowsiness, pseudoparkinsonism and other extrapyramidal symptoms 60%;
Dry mouth, blurred vision, constipation, nausea, vomiting, diarrhoea, nasal stuffiness, pallor; galactorrhoea, breast engorgement, amenorrhoea, inhibition of ejaculation, peripheral oedema; dermatitis, skin eruptions. Rarely, nocturnal confusion, hyperactivity, lethargy, psychotic reactions, restlessness, headache, photosensitivity, parotid swelling.
Potentially Fatal: Prolongation of QTc interval resulting to torsades de pointes type arrhythmias and polymorphic ventricular tachycardia.
Interaction
Potentiates adverse effects of anticholinergics. Concurrent use of TCAs leads to raised blood levels of both drugs. May antagonise effects of levodopa, bromocriptine and other dopamine agonists. Avoid co-admin with drugs that cause electrolyte imbalance. Monitor phenytoin therapy due to inconsistent effects of thioridazine on phenytoin levels. Potentially Fatal: Increased risk of QT prolongation with class IA and class II antiarrhythmics, astemizole, cisapride, pimozide, droperidol, erythromycin IV, sparfloxacin, terfenadine, clarithromycin and other drugs that may prolong QT interval. Potentiates CNS depression with opioids. Increased risk of arrhythmias with ephedrine-like drugs e.g. phenylpropanolamine. Increased thioridazone levels with fluovoxamine, pindolol, propranolol, ritonavir...
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