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Gasex 40
Sun Pharmaceutical (Bangladesh) Ltd.
Generic: Famotidine
Safety Advices
বাংলা
English
UNSAFE
It is unsafe to consume alcohol with Gasex 40.
SAFE IF PRESCRIBED
Gasex 40 is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
SAFE IF PRESCRIBED
Gasex 40 is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
SAFE
Gasex 40 does not usually affect your ability to drive.
CAUTION
Gasex 40 should be used with caution in patients with kidney disease. Dose adjustment of Gasex 40 may be needed. Please consult your doctor.
SAFE IF PRESCRIBED
Gasex 40 is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Gasex 40 may not be needed in these patients. Please consult your doctor.
Medicine Overview of Gasex 40mg Tablet
Introduction
Gasex 40 is an antacid. It reduces the amount of acid produced by your stomach. It is used to treat and prevent heartburn, indigestion and other symptoms caused by too much acid in the stomach. It is also used to treat and prevent stomach ulcers, reflux disease and some other rare conditions. Gasex 40 is also commonly prescribed to prevent stomach ulcers and heartburn caused due to the use of painkillers. It must be swallowed whole with water before or after a meal. The medicine must be taken in the dose and duration advised by the doctor. This medicine should...
... Show moreUses of Gasex 40
- Gastroesophageal reflux disease (Acid reflux)
- Peptic ulcer disease
Side effects of Gasex 40
Common
- Headache
- Diarrhea
- Constipation
How to use Gasex 40
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Gasex 40 is to be taken with food.
How Gasex 40 works
Gasex 40 is a histamine H2 receptor antagonist. It works by reducing the acid produced in the stomach. This helps to relieve acid-related indigestion and heartburn.
What if you forget to take Gasex 40?
If you miss a dose of Gasex 40, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
- Gasex 40 is a well tolerated and safe medicine with a very low incidence of side effects.
- Take it with or without food.
- If you are also taking other medications to treat acidity (e.g., antacid), take them 2 hours before or after taking Gasex 40.
- Avoid taking soft drinks, citrus fruits like orange and lemon, which can irritate the stomach and increase acid secretion.
- Inform your doctor if you do not feel better after taking Gasex 40 for 2 weeks as you may be suffering from some other problems.
- Inform your doctor if you have ever been diagnosed with kidney disease as dose of your medicine may need to be adjusted.
- Do not stop taking the medication without talking to your doctor.
Brief Description
Indication
Heartburn, Peptic ulcer, Dyspepsia, Urticaria, Zollinger-Ellison syndrome, Gastroesophageal reflux disease (GERD)
Administration
May be taken with or without food.
Reconstitution: For IV inj: Famotidine 20 mg is diluted to a total of 5 or 10 mL w/ NaCl 0.9% inj or dextrose 5% or 10% inj, lactated Ringer's, water for inj soln to provide a soln containing approx 4 or 2 mg/mL, respectively.
For intermittent IV infusion: Famotidine 20 mg is added to dextrose 5% inj 100 mL or NaCl 0.9% inj, lactated Ringer's soln, water for inj soln to provide a soln containing approximately 0.2 mg/mL.
IV Administration
Infuse at rate no faster than 10 mg/min
Adult Dose
Oral
Benign gastric and duodenal ulceration
Adult: 40 mg daily at bedtime for 4-8 wk or 20 mg bid. Maintenance: 20 mg at bedtime to prevent recurrence of duodenal ulceration.
Gastro-oesophageal reflux disease
Adult: 20 mg bid for 6-12 wk or up to 40 mg bid if there is oesophageal ulceration. Maintenance: 20 mg bid to prevent recurrence.
Zollinger-Ellison syndrome
Adult: Initially, 20 mg 6 hrly, up to 800 mg/day if necessary.
Non-ulcer dyspepsia ; Heartburn
Adult: 10-20 mg once or bid.
Child Dose
Peptic Ulcer
1-16 years: 0.5 mg/kg PO at bedtime; not to exceed 40 mg/day
Gastroesophageal Reflux Disease
12 years: 10-20 mg q12 hr; may take 15-60 min before eating foods that could cause heartburn
Renal Dose
Renal impairment:
CrCl (ml/min) Dosage Recommendation
<50 Reduce the dose by half or increase dosing interval to 36-48 hr.
Contraindication
Hypersensitivity.
Mode of Action
Famotidine competitively blocks histamine at H2-receptors thus reducing basal, nocturnal and stimulated gastric acid secretion. Pepsin secretion is reduced resulting in decreased peptic activity.
Precaution
Impaired renal function. Long term treatment should be avoided.
Lactation: Drug enters breast milk; use not recommended
Side Effect
1-10% Headache (4.7%),Diarrhea (1.7%),Dizziness (1.3%),Constipation (1.2%) Frequency Not Defined Body as a whole: Fever, asthenia, fatigue Cardiovascular: Arrhythmia, AV block, palpitation; prolonged QT interval in patients with impaired renal function, has been reported very rarely Gastrointestinal: Cholestatic jaundice, hepatitis, liver enzyme abnormalities, vomiting, nausea, abdominal discomfort, anorexia, dry mouth Hematologic: Rare cases of agranulocytosis, pancytopenia, leukopenia, thrombocytopenia Hypersensitivity: Anaphylaxis, angioedema, orbital or facial edema, urticaria, rash, conjunctival injection Musculoskeletal: Rhabdomyolysis, musculoskeletal pain including muscle cramps, arthralgia Nervous system/psychiatric: Grand mal seizure; psychic disturbances, which were reversible in cases for which follow-up was obtained, including hallucinations, confusion, agitation, depression, anxiety, decreased...
... Show morePregnancy Category Note
Pregnancy Available data in pregnant women are insufficient to establish a drug-associated risk of major birth defects, miscarriage or adverse maternal or fetal outcomes Animal data Animal reproduction studies have shown no adverse development effects at doses up to approximately 243 times, the recommended human dose of 80 mg per day for treatment of erosive esophagitis Lactation There are limited data available on presence in human breast milk; there were no effects on breastfed infant; there are no data on famotidine effects on milk production; drug reported present in milk of lactating rats; developmental and health benefits of breastfeeding should...
... Show moreInteraction
Antacids slightly decrease the bioavailability of famotidine. May reduce serum concentration of ketoconazole and itraconazole.
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